2022
DOI: 10.1016/j.yexcr.2022.113342
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PGAM5 interacts with Bcl-rambo and regulates apoptosis and mitophagy

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Cited by 6 publications
(8 citation statements)
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“…In human 293T cells, BCL-RAMBO binds to PGAM5, and the BCL-RAMBO TM domain is required for their interaction (Hashino et al, 2022). PGAM5 promotes BCL-RAMBO-induced caspase 3/7 activity, but suppresses the increase of MAP1LC3B-II levels induced by BCL-RAMBO (Hashino et al, 2022). These findings reveal that PGAM5 promotes BCL-RAMBO-induced apoptosis and conversely suppresses BCL-RAMBO-induced mitophagy.…”
Section: Regulation Of Bcl-rambo-induced Apoptosis and Mitophagy By P...mentioning
confidence: 89%
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“…In human 293T cells, BCL-RAMBO binds to PGAM5, and the BCL-RAMBO TM domain is required for their interaction (Hashino et al, 2022). PGAM5 promotes BCL-RAMBO-induced caspase 3/7 activity, but suppresses the increase of MAP1LC3B-II levels induced by BCL-RAMBO (Hashino et al, 2022). These findings reveal that PGAM5 promotes BCL-RAMBO-induced apoptosis and conversely suppresses BCL-RAMBO-induced mitophagy.…”
Section: Regulation Of Bcl-rambo-induced Apoptosis and Mitophagy By P...mentioning
confidence: 89%
“…To identify BCL-RAMBO-interacting partner genes, human BCL-RAMBO-expressing fly lines have been crossed with fly lines with the deletion of or mutations in specific genes. Comprehensive screening using fly lines deficient for the second chromosome revealed that the BCL-RAMBO-induced rough eye phenotype is also partly suppressed by mutations in or the knockdown of porin and pgam5-2 (Nakazawa et al, 2016;Matsubara et al, 2019;Hashino et al, 2022). The genetic interaction of BCL-RAMBO with Porin or Pgam5 has been confirmed in human cultured cell lines.…”
Section: Regulation Of Bcl-rambo Expression By Micrornas (Mirnas)mentioning
confidence: 91%
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