pH and Redox Dual-Responsive Mesoporous Silica Nanoparticle as Nanovehicle for Improving Fungicidal Efficiency

Abstract

Prochloraz (Pro) controlled-release nanoparticles (NPs) based on bimodal mesoporous silica (BMMs) with redox and pH dual responses were successfully prepared in this study. BMMs was modified by a silane coupling agent containing a disulfide bond, and β-cyclodextrin (β-CD) was grafted on the surface of the NPs through host–guest interaction. Pro was encapsulated into the pores of nanoparticles by physical adsorption. NPs had a spherical structure, and their average diameter was 546.4 ± 3.0 nm as measured by dynamic light scattering. The loading rate of Pro was 28.3%, and it achieved excellent pH/redox dual-responsive release performance under acidic conditions. Foliage adhesion tests on tomato leaves showed that the NPs had good adhesion properties compared to the commercial formulation. Owing to the protection of the nanocarrier, NPs became more stable under ultraviolet light and high temperature, which improves the efficient utilization of Pro. Biological activity tests showed that the NPs exhibited effective antifungal activity, and the benign biosafety of the nanocarrier was also observed through toxicology tests on cell viability and the growth of Escherichiacoli (E. coli). This work provides a promising approach to improving the efficient utilization of pesticides and reducing environmental pollution.

A pH‐ and redox‐stimulated responsive hollow mesoporous silica for triggered delivery of fungicides to control downy mildew of Luffa cylindrica

“…Wu et al prepared mesoporous silica controlled-release nanoparticles (546.4 nm) with dual redox and pH response, and the results showed that excellent pH/redox dual response release performance was achieved under acidic conditions, which is consistent with our study. 36 The earlier results indicate that DMM@HMS-SS-COS exhibited good controlledrelease properties, which is beneficial for long-term disease control in leaves.…”

Porous Silica Nanocarriers: Advances in Structural Orientation and Modification to Develop Sustainable Pesticide Delivery Systems

“…To achieve acidic pH influenced release of pesticide from PSNs, surface functionalization of PSNs by low-pH-sensitive linkers have been used in several studies. ,,, For instance, Liang and co-workers developed a pH-responsive pesticide delivery system using coordination of Cu ions and tannic acid on MSN loaded with pyraclostrobin (Pyr) (MSNs-TA-Cu@Pyr). They evaluated the release profile of Pyr at different pH values (4.5, 6.0, and 7.4) at ambient temperatures.…”

“…In summary, the ability to release the pesticide dimethomorph (DMM) was improved by cleaving the disulfide bond in the presence of glutathione, making the HSN modified with a disulfide bond and capped with chitosan oligosaccharide (COS)@DMM a highly effective redox-responsive pesticide formulation. PSNs also successfully delivered avermectin and prochloraz using a similar strategy.…”

Design and fabrication of intracellular therapeutic cargo delivery systems based on nanomaterials: current status and future perspectives

“…[127][128][129][130] For instance, Wu et al prepared prochloraz (Pro) controlled-release nanoparticles against fungi based on bimodal mesoporous silica (BMM) with redox and pH dual responses. 131 (Fig. 11) In addition, Huang et al developed a controlled drug release system using near-infrared light (NIR) and external stimulation of protein coating.…”

“…Fig.11(A) Schematic diagram of pH and redox dual-responsive mesoporous silica nanoparticle 131. (B) Schematic diagram of lysozyme and near-infrared light-responsive drug delivery system 132.…”