pH and redox dual stimulate-responsive nanocarriers based on hyaluronic acid coated mesoporous silica for targeted drug delivery

Lin, Jiantao; Du, Jikun; Yang, Yi-Qiu; Li, Li; Zhang, Dawei; Liang, Cui-Ling; Wang, Jie; Mei, Jun; Wang, Guan-Hai

doi:10.1016/j.msec.2017.08.036

Cited by 56 publications

(28 citation statements)

References 40 publications

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“…Among them, mesoporous silica nanoparticles (MSN) have been well studied. Utilizing disulfide bonds to link modified structures to nanoparticles’ surface can enrich the function of nanoparticles [ 43 ], such as enhancing the redox-responsiveness and targeting capabilities [ 42 ]. In addition, disulfide bonds can be linked with genes or drugs [ 41 ], which can realize the rapid release of genes or drugs under reducing environments.…”

Section: Application Of Disulfide Bonds In Redox-responsive Delivery mentioning

confidence: 99%

Advances in redox-responsive drug delivery systems of tumor microenvironment

et al. 2018

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With the improvement of nanotechnology and nanomaterials, redox-responsive delivery systems have been studied extensively in some critical areas, especially in the field of biomedicine. The system constructed by redox-responsive delivery can be much stable when in circulation. In addition, redox-responsive vectors can respond to the high intracellular level of glutathione and release the loaded cargoes rapidly, only if they reach the site of tumor tissue or targeted cells. Moreover, redox-responsive delivery systems are often applied to significantly improve drug concentrations in targeted cells, increase the therapeutic efficiency and reduce side effects or toxicity of primary drugs. In this review, we focused on the structures and types of current redox-responsive delivery systems and provided a comprehensive overview of relevant researches, in which the disulfide bond containing delivery systems are of the utmost discussion.

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Section: Application Of Disulfide Bonds In Redox-responsive Delivery mentioning

confidence: 99%

Advances in redox-responsive drug delivery systems of tumor microenvironment

et al. 2018

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“…8 Therefore, nonviral carriers have great potential in the application of gene therapy due to their better safety profile. gold NP, 10 and mesoporous silica, 11 have been developed to prepare antitumor nanomedicines with passive tumor-targeting properties due to the "enhanced permeability and retention" effect. 12 Among these nanomaterials, selenium nanoparticles (SeNPs) have attracted increasing attention in the field of drug delivery vehicle in cancer therapy.…”

Section: Introductionmentioning

confidence: 99%

siRNA-loaded selenium nanoparticle modified with hyaluronic acid for enhanced hepatocellular carcinoma therapy

Xia¹,

Guo²,

Xu³

et al. 2018

IJN

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Background Small interfering RNA (siRNA) as a new therapeutic modality holds promise for cancer treatment. However, the traditional viral carriers are prone to immunogenicity and risk of insertional mutagenesis. Methods In order to provide a tumor-targeted delivery carrier of siRNA in cancer therapy, the hyaluronic acid (HA)-selenium (Se)-polyethylenimine (PEI) nanoparticle (NP) was fabricated by decorating SeNP with HA as a tumor-targeting moiety and by linking the polycationic polymers polyethylenimine PEI onto the surface of SeNP. The siRNA was loaded to the surface of SeNP HA-Se-PEI via the electrostatic interaction between siRNA and PEI to prepare the functionalized SeNP HA-Se-PEI@siRNA. Results The HA-Se-PEI@siRNA was internalized into the HepG2 cell mainly in a clathrin-mediated endocytosis manner. Owing to the active tumor-targeted effect mediated by HA, HA-Se-PEI@siRNA achieved the obvious higher transfection efficiency, greater gene silencing ability, and stronger cytotoxicity in the HepG2 cell compared with the passive tumor-targeted NP Se-PEI@siRNA. The knockdown of hairy and enhancer of split 5 by HA-Se-PEI@siRNA induced the HepG2 cell cycle arrest at the G0/G1 phase and apoptosis. Furthermore, the treatment with HA-Se-PEI@siRNA resulted in greater antitumor efficacy compared with the Se-PEI@siRNA in vitro and in vivo. In addition, the HA-Se-PEI@siRNA was almost no toxic to the key organs of mice. Conclusion These findings provided an alternative therapeutic route for targeted cancer treatments.

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“…Effective uptake of drugs is a very crucial issue for favorable treatment outcoming. A lot of researches showed that the expression of hyaluronic acid receptor CD44 in cancer cells is much more than that in human normal cells [29]. Therefore, the expression of CD44 in A549 cells should be examined to verify whether hyaluronic acid receptor CD44 contributes to the uptake of HA-Se@PTX in A549 cells.…”

Section: Selective Uptake Of Ha-se@ptx Nanoparticlesmentioning

confidence: 99%

Hyaluronic acid-modified selenium nanoparticles for enhancing the therapeutic efficacy of paclitaxel in lung cancer therapy

Zou

Chen

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Targeted delivery of chemotherapeutics by functionalized nanoparticles exhibits a wonderful prospect for cancer treatment. In this paper, selenium nanoparticles (SeNPs) was linked with hyaluronic acid (HA) to prepare tumor-targeted delivery vehicle HA-SeNPs, and HA-SeNPs was loaded with paclitaxel (PTX) to fabricate functionalized selenium nanoparticles HA-Se@PTX. HA-Se@PTX showed greater uptake in A549 cells in comparison with that in HUVEC, verifying HA-mediated specific uptake of HA-Se@PTX. HA-Se@PTX was capable of entering A549 cells via clathrin-associated endocytosis and showed faster drug release in cancer cell microenvironment in comparison with normal physiological environment. HA-Se@PTX could obviously inhibit the proliferation, migration and invasion of A549 cells and trigger A549 cells apoptosis. Moreover, active targeting functionalized selenium nanoparticles HA-Se@PTX showed greater in vivo antitumor activity compared with free PTX or passive targeting delivery system Se@PTX. In addition, HA-Se@PTX exhibited negligible toxicity on the major organs of mice. In a word, HA-Se@PTX may develop into a valuable nanoscale antitumor drug agent for lung cancer treatment.

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pH and redox dual stimulate-responsive nanocarriers based on hyaluronic acid coated mesoporous silica for targeted drug delivery

Cited by 56 publications

References 40 publications

Advances in redox-responsive drug delivery systems of tumor microenvironment

Advances in redox-responsive drug delivery systems of tumor microenvironment

siRNA-loaded selenium nanoparticle modified with hyaluronic acid for enhanced hepatocellular carcinoma therapy

Hyaluronic acid-modified selenium nanoparticles for enhancing the therapeutic efficacy of paclitaxel in lung cancer therapy

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