pH- and Thermo-sensitive Hydrogel Nanoparticles

Sahoo, Sanjeeb K.; De, T. K.; Ghosh, Paritosh; Maitra, Amarnath

doi:10.1006/jcis.1998.5692

Cited by 60 publications

(26 citation statements)

References 20 publications

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“…An abrupt volumetric change is expected for this purpose because it is induced by such controllable parameters as temperature, pH, additives concentration, electrical field and so on (Ishihara et al, 1984;Hoffman et al, 1986;Bae et al, 1987;Sawahata et al, 1990;Dong and Hoffman, 1991;Baker and Siegel, 1996;Kaneko et al, 1997;Sahoo et al, 1998;Park, 1999;Ebara et al, 2001). For instance, Nisopropylacrylamide (NIPAAm)/butyl methacrylate (BMA) gel was used to control the release rate of indomethacin by the abrupt swelling/shrinkage induced by temperature changes (Bae et al, 1987).…”

Section: Introductionmentioning

confidence: 99%

“…For instance, Nisopropylacrylamide (NIPAAm)/butyl methacrylate (BMA) gel was used to control the release rate of indomethacin by the abrupt swelling/shrinkage induced by temperature changes (Bae et al, 1987). The release rate of dextran from vinylpyrrolidone (VP)/acrylic acid (AA) gel can be controlled by pH and temperature (Sahoo et al, 1998). One style of the applications of stimuli-sensitive volumetric changes to control the release rate of solutes from the hydrogel is achieved by squeezing effect (Yonese, 1997).…”

Section: Introductionmentioning

confidence: 99%

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Brownian Dynamics Simulation Study of Self-Diffusion of a Charged Particle in Swollen Counter-Charged Hydrogel Modeled as Cubic Lattice.

Miyata

Endo

Ohmori

et al. 2002

J. Chem. Eng. Japan

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The tracer diffusion of a charged particle in an oppositely charged cubic lattice as a simplest model of charged hydrogel was studied by a Brownian dynamics simulation. The effect of the electrostatic attractive interaction between the tracer particle and the cubic lattice on the self-diffusion coefficient was mainly discussed, when the mesh size of the cubic lattice was sufficiently larger than the diameter of the particle. The charge density of the cubic lattice structure and the electrolyte concentration in the solvent were varied. The electrostatic force acting on the tracer particle was calculated using the potential screened by an electric double layer. The self-diffusion coefficient of the tracer particle significantly decreases as the charge density of the cubic lattice increases, while the increase in the electrolyte concentration in the solvent induces the disappearance of the effect of electrostatic attractive interaction on the self-diffusion coefficient, resulting into the asymptotical behavior to those observed in the non-charged cubic lattice. 2-Order reduction in the self-diffusion coefficient was obtained in this simulation and this shows the applicability of the control of diffusivity of ionic solutes in the swollen hydrogel by means of introducing ionic species covalently into the hydrogels. In the spatial distribution of the probability density of the charged tracer particle, the stochastic path along which the tracer particle tends to move was observed in the charged cubic lattice, which is caused by electrostatic potentials. The reduction of the self-diffusion coefficient in the charged cubic lattice is due to the transient entrapment at the point of local minimum of potential energy inside the stochastic paths.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Brownian Dynamics Simulation Study of Self-Diffusion of a Charged Particle in Swollen Counter-Charged Hydrogel Modeled as Cubic Lattice.

Miyata

Endo

Ohmori

et al. 2002

J. Chem. Eng. Japan

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show abstract

“…Maitra's group [161,162] reported NIPAM-based copolymer gel (∼50 nm) using solution polymerization employing ammonium persulfate/ferrous ammonium sulfate (APS/FAS) as the initiating system at room temperature for delivery of nonsteroidal anti-inflammatory drugs. We have recently developed poly(N-isopropylacrylamideco-vinyl pyrrolidone) [poly(NIPAM-co-VP)] nanogels with an average size of 40 nm for the delivery of anticancer drugs (Figure 6.13).…”

Section: Solution Polymerizationmentioning

confidence: 99%

Nanogels: Chemistry to Drug Delivery

Yallapu

Reddy

Labhasetwar

2007

Biomedical Applications of Nanotechnology

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“…This requires the use of solvents that can selectively dissolve the surfactants. This step makes hydrogel micro/nano-particle recovery non-trivial and sometimes leads to the leaching of the active materials from the hydrogel network [31]. Thus, using a biocompatible surfactant for the formulation of w/o microemulsion for the hydrogel micro/nano-particle syntheses is a very promising prospect.…”

Section: Introductionmentioning

confidence: 99%