pH-bioresponsive poly(ε-caprolactone)-based polymersome for effective drug delivery in cancer and protein glycoxidation prevention

Ghorbanizamani, Faezeh; Moulahoum, Hichem; Sanli, Serdar; Bayır, Ece; Zihnioğlu, Figen; Timur, Suna

doi:10.1016/j.abb.2020.108643

Cited by 15 publications

(6 citation statements)

References 64 publications

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“…Thus, polymersome self-assemblies may be degradable or non-degradable, depending on the selected monomers [ 125 ]. While degradable monomers include structures from aliphatic polyesters and polycarbonates, such as PEG [ 126 ], poly(lactic acid) (PLA) [ 127 ], polycaprolactone (PCL) [ 128 ], and poly(trimethylene carbonate) (PTMC) [ 129 ], non-degradable ones include conjugated or aromatic hydrocarbon blocks, such as poly(ethyl ethylene) (PEE) [ 78 ], poly(butadiene) (PBD) [ 130 ], and PS [ 131 ], among others [ 70 ]. Independent of the monomer degradability, the hydrophobic and hydrophilic amphiphilic organizations formed by their self-assembly constitute the bilayer of the polymersomes, defining their thickness, stability, and permeability.…”

Section: Polymersomes As a Platform For Anticancer Therapeutic Deliverymentioning

confidence: 99%

Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

et al. 2022

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Polymersomes are biomimetic cell membrane-like model structures that are self-assembled stepwise from amphiphilic copolymers. These polymeric (nano)carriers have gained the scientific community’s attention due to their biocompatibility, versatility, and higher stability than liposomes. Their tunable properties, such as composition, size, shape, and surface functional groups, extend encapsulation possibilities to either hydrophilic or hydrophobic cargoes (or both) and their site-specific delivery. Besides, polymersomes can disassemble in response to different stimuli, including light, for controlling the “on-demand” release of cargo that may also respond to light as photosensitizers and plasmonic nanostructures. Thus, polymersomes can be spatiotemporally stimulated by light of a wide wavelength range, whose exogenous response may activate light-stimulable moieties, enhance the drug efficacy, decrease side effects, and, thus, be broadly employed in photoinduced therapy. This review describes current light-responsive polymersomes evaluated for anticancer therapy. It includes light-activable moieties’ features and polymersomes’ composition and release behavior, focusing on recent advances and applications in cancer therapy, current trends, and photosensitive polymersomes’ perspectives.

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Section: Polymersomes As a Platform For Anticancer Therapeutic Deliverymentioning

confidence: 99%

Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

et al. 2022

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“…The swelling or deswelling properties in response to pH were observed at specific time intervals and size changes were recorded. The swelling or deswelling ratios (SR) were measured with the equation: SR = (Wv − Ws)/Ws (Wv: at specific time intervals, the hydrogels were taken out from the tubes and gently blotted with filter paper to remove the excess of water lying on the surfaces, and weighed; Ws: hydrogels’ initial weight) [ 12 , 22 ].…”

Section: Methodsmentioning

confidence: 99%

Dual-Responsive Alginate Hydrogel Constructed by Sulfhdryl Dendrimer as an Intelligent System for Drug Delivery

Lei

Zhang

et al. 2022

Molecules

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Intelligent stimulus-triggered release and high drug-loading capacity are crucial requirements for drug delivery systems in cancer treatment. Based on the excessive intracellular GSH expression and pH conditions in tumor cells, a novel glutathione (GSH) and pH dual-responsive hydrogel was designed and synthesized by conjugates of glutamic acid-cysteine dendrimer with alginate (Glu-Cys-SA) through click reaction, and then cross-linked with polyethylene glycol (PEG) through hydrogen bonds to form a 3D-net structure. The hydrogel, self-assembled by the inner disulfide bonds of the dendrimer, is designed to respond to the GSH heterogeneity in tumors, with a remarkably high drug loading capacity. The Dox-loaded Glu-Cys-SA hydrogel showed controlled drug release behavior, significantly with a release rate of over 76% in response to GSH. The cytotoxicity investigation indicated that the prepared DOX-loaded hydrogel exhibited comparable anti-tumor activity against HepG-2 cells with positive control. These biocompatible hydrogels are expected to be well-designed GSH and pH dual-sensitive conjugates or polymers for efficient anticancer drug delivery.

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“…More examples of polymersome applications are discussed in the Supporting Information. Researchers have been designing multifunctional polymersomes for different biological applications such as diagnosis and smart drug delivery. , Table summarizes the most recently reported antibody bioconjugated polymeric nanoparticles for therapeutic or imaging applications.…”

Section: Polymersomesmentioning

confidence: 99%

Surface Biomodification of Liposomes and Polymersomes for Efficient Targeted Drug Delivery

et al. 2021

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Chemotherapy has seen great progress in the development of performant treatment strategies. Nanovesicles such as liposomes and polymersomes demonstrated great potential in cancer therapy. However, these nanocarriers deliver their content passively, which faces a lot of constraints during blood circulation. The main challenge resides in degradation and random delivery to normal tissues. Hence, targeting drug delivery using specific molecules (such as antibodies) grafted over the surface of these nanocarriers came as the answer to overcome many problems faced before. The advantage of using antibodies is their antigen/antibody recognition, which provides a high level of specificity to reach treatment targets. This review discusses the many techniques of nanocarrier functionalization with antibodies. The aim is to recognize the various approaches by describing their advantages and deficiencies to create the most suitable drug delivery platform. Some methods are more suitable for other applications rather than drug delivery, which can explain the low success of some proposed targeted nanocarriers. In here, a critical analysis of how every method could impact the recognition and targeting capacity of some nanocarriers (liposomes and polymersomes) is discussed to make future research more impactful and advance the field of biomedicine further.

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pH-bioresponsive poly(ε-caprolactone)-based polymersome for effective drug delivery in cancer and protein glycoxidation prevention

Cited by 15 publications

References 64 publications

Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

Dual-Responsive Alginate Hydrogel Constructed by Sulfhdryl Dendrimer as an Intelligent System for Drug Delivery

Surface Biomodification of Liposomes and Polymersomes for Efficient Targeted Drug Delivery

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