pH Changes in Front of the Hydrogen Generating Electrode During Measurements with an Electrolytic Hydrogen Clearance Sensor

Baumgärtl, H.; Zimelka, W.; Lübbers, D. W.

doi:10.1007/978-1-4684-8181-5_14

Cited by 10 publications

(4 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Unlike diathermy, laser or cryotherapy, electrolysis produces cell necrosis with minimal thermal effect. 24,25 Cell necrosis is caused by a combination of altered intracellular pH 26,27 and the liberation of cytotoxic gases into the local environment. [28][29][30][31][32] Before any new treatment can be used in the clinical setting, it is essential that it be shown as far as possible to be completely safe.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Safety Of Electrolytically Induced Hepatic Necrosis In A Pig Model

Wemyss‐Holden

Hall

Robertson

et al. 2000

Aust. N.Z. J. Surg.

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Safety Of Electrolytically Induced Hepatic Necrosis In A Pig Model

Wemyss‐Holden

Hall

Robertson

et al. 2000

Aust. N.Z. J. Surg.

View full text Add to dashboard Cite

show abstract

“…Electrodes placed either in or directly adjacent to the Histology showed that in 17 rats 'electrolytic segmentectomy' resulted in destruction of the entire tumour de-tumours cause tumour cell death by the localised production and action of cytotoxic electrode products [34,35]. posit (7/11 left lobe and 10/11 right lobe).…”

Section: Resultsmentioning

confidence: 99%

Electrolytic Treatment of Colorectal Liver Tumour Deposits in a Rat Model: A Technique with Potential for Patients with Unresectable Liver Tumours

Wemyss‐Holden¹,

Robertson²,

Hall³

et al. 2000

Dig Dis

View full text Add to dashboard Cite

Background/Aims: Patients with unresectable malignant liver tumours have a poor prognosis. A technique is needed which improves long-term survival. Previous studies in the rat have shown that electrolysis is a safe, predictable and reproducible method for creating areas of necrosis in the normal rat liver. This study examined the effects of electrolysis on colorectal liver ‘metastases’ in the rat. Methods: Tumours of colorectal origin were implanted into the livers of Wistar-WAG rats. Two weeks after implantation the tumours were treated with electrolysis. A direct current generator, connected to 2 platinum intrahepatic electrodes was used to examine the effects of various electrode configurations on the extent of tumour necrosis. Results: Significant (p<0.001) tumour ablation was achieved with all electrode configurations. Tumour necrosis was more complete (p<0.05) with the electrodes positioned on either side of the tumour than with both electrodes placed in the centre of the tumour. Liver enzymes (AST and ALT) were significantly (p<0.001) elevated after treatment, but returned towards normal by 2 days. Conclusions: This study has shown that colorectal liver ‘metastasis’ can be ablated by electrolysis in a rat model. Two separate mechanisms of tumour ablation were observed: With the electrodes directly in or adjacent to the tumour, necrosis resulted from the action of cytotoxic electrode products, whereas by positioning the electrodes proximal to the tumour, necrosis was induced by a ‘secondary’ ischaemic effect. The findings confirm the view that electrolysis has great potential for treating patients with unresectable malignant liver tumours.

show abstract

“…A small direct electrical current ( 50 mA) is passed between two electrodes which become polarized. A pH gradient is established [20,21] and cytotoxic electrode products are liberated [22][23][24][25][26]. Well defined zones of tissue necrosis are produced around the tip of each electrode.…”

Section: Introductionmentioning

confidence: 99%

A new treatment for unresectable liver tumours: long-term studies of electrolytic lesions in the pig liver

Wemyss‐Holden¹,

ROBERTSON²,

Dennison³

et al. 2000

Clinical Science

View full text Add to dashboard Cite

The majority of liver tumours are inoperable and an alternative treatment to surgical resection is urgently needed. Electrolysis has been investigated in a rat model and the procedure is safe, with accurate and predictable effects. The necrosis produced has also been shown to cause destruction of tumour deposits in the rat liver. A similar evaluation in a large animal model was necessary before clinical trials could commence. Using platinum electrodes connected to a d.c. generator, areas of hepatic necrosis were created in the pig liver. Animals were killed at various time points after treatment to assess the extent of healing. Treatment was uneventful and all animals made a full recovery. No animal died from the treatment or had to be killed prematurely. After 2 days of treatment, healing was minimal but at successive time points there was progressive evidence of healing, such that after 4 months, the original electrolytic lesion was greatly reduced in size and the large area of necrosis seen at the early time points was largely replaced by a fibrous scar with only small islands of necrotic tissue. In a large animal model, electrolysis is a safe method for creating areas of hepatic necrosis. The lesions heal with time and are associated with minimal morbidity. The results support a trial of electrolysis in patients with unresectable liver tumours.

show abstract

pH Changes in Front of the Hydrogen Generating Electrode During Measurements with an Electrolytic Hydrogen Clearance Sensor

Cited by 10 publications

References 4 publications

The Safety Of Electrolytically Induced Hepatic Necrosis In A Pig Model

The Safety Of Electrolytically Induced Hepatic Necrosis In A Pig Model

Electrolytic Treatment of Colorectal Liver Tumour Deposits in a Rat Model: A Technique with Potential for Patients with Unresectable Liver Tumours

A new treatment for unresectable liver tumours: long-term studies of electrolytic lesions in the pig liver

Contact Info

Product

Resources

About