pH/redox dual-stimuli-responsive cross-linked polyphosphazene nanoparticles for multimodal imaging-guided chemo-photodynamic therapy

Jing, Xunan; Zhi, Zhe; Jin, Liming; Wang, Fei; Wu, Youshen; Wang, Daquan; Yan, Kai; Shao, Yongping; Meng, Lingjie

doi:10.1039/c9nr01194c

Cited by 80 publications

(48 citation statements)

References 43 publications

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“…Moreover, compared with the elemental analysis of HMSNs, the EDS spectrum of CaO 2 @HMSNs-PAA showed extra intensive signals from the elements Ca and C, indicating the successful CaO 2 loading and PAA coating (Figure 1 E-F). Furthermore, the SEM images and EDS mapping images in Figure 1 G-L further confirmed the successful synthesis of CaO 2 @HMSNs-PAA 49 , 51 , 52 , 58 .…”

Section: Resultssupporting

confidence: 59%

Efficacy-shaping nanomedicine by loading Calcium Peroxide into Tumor Microenvironment-responsive Nanoparticles for the Antitumor Therapy of Prostate Cancer

Zhu

Tang

et al. 2020

Theranostics

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Rationale: Prostate cancer has become one of the most threatening malignant tumors in men, leading to an imperative need to develop effective and safe therapies. Because of the unique metabolism of tumor cells, the tumor microenvironment (TME) exhibits distinctive properties compared with normal tissues, among which the pH difference has been utilized as an ideal antitumor strategy. Herein, we introduce a reactive oxygen species (ROS)-controlled-release nanosystem with TME-responsiveness by applying hollow mesoporous silica nanoparticles (HMSNs) as carriers loaded with calcium peroxide (CaO 2 ) and coated with polyacrylic acid (PAA) to construct the functional material CaO 2 @HMSNs-PAA. The differences in pH values and exogenous ROS scavenging abilities between the tumor tissue and normal tissues and the dual pH-responsiveness from CaO 2 and PAA lay a scientific foundation for the application of CaO 2 @HMSNs-PAA in the tumor-selective therapy for prostate cancer. Methods: The morphology and the structure of the nanosystem were characterized by the transmission electron microscope, scanning electron microscope, energy-dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, zeta potential, dynamic light scattering measurement, low-angle X-ray diffraction patterns and nitrogen adsorption/desorption isotherm. The CaO 2 loading capacity and release profiles in different buffer solutions were determined by inductively coupled plasma-mass spectrometry. The in vitro intracellular uptake of CaO 2 @HMSNs-PAA was explored on the PC-3 prostate cancer cell line via confocal laser scanning microscopy. The CCK-8 cell proliferation assay was conducted to evaluate the cytotoxicity of CaO 2 @HMSNs-PAA against PC-3 cells. ROS produced by CaO 2 @HMSNs-PAA was observed by a fluorescence microscope. The flow cytometry was utilized to analyze the apoptosis of PC-3 cells induced by CaO 2 @HMSNs-PAA. The Western blot analysis was performed to detect expressions of critical mitochondria-mediated apoptosis markers in PC-3 cells after incubation with CaO 2 @HMSNs-PAA. The in vivo biosafety and antitumor efficacy were evaluated out on BALB/c mice and BALB/c nude mice subcutaneously transplanted with PC-3 cells, respectively. Results: Comprehensive characterizations indicated the successful synthesis of CaO 2 @HMSNs-PAA with significant TME-responsiveness. The experimental results demonstrated that the well-developed nanocarrier could efficiently deliver CaO 2 to the tumor site and release ROS in response to the decreased pH value of TME, exerting ideal antitumor effects both in vitro and ...

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Section: Resultssupporting

confidence: 59%

Efficacy-shaping nanomedicine by loading Calcium Peroxide into Tumor Microenvironment-responsive Nanoparticles for the Antitumor Therapy of Prostate Cancer

Zhu

Tang

et al. 2020

Theranostics

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“…Highly crosslinked polyphosphazene nano/micro materials, a kind of novel versatile hybrid material referring to polymers synthesized via polycondensation between hexachlorotriphosphazene (HCCP) and polyamino (or polyhydroxyl) monomers, have been designed for use in cell imaging, drug delivery, sensing, and ecological environment . The polyphosphazenes have special characteristics including highly crosslinked structure, water and organic media dispersibility, and biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Facile synthesis of amino‐functionalized polyphosphazene microspheres and their application for highly sensitive fluorescence detection of Fe³⁺

Chen

Liu

et al. 2020

J of Applied Polymer Sci

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Amino-functionalized highly crosslinked organic-inorganic hybrid polyphosphazene microspheres were prepared via a one-pot polycondensation method and served as a fluorescent sensor for the detection of Fe 3+ in solution. With the introduction of p-phenylenediamine unites, the polyphosphazene microspheres could be endowed with fluorescent property and abundant active amino groups on the surface. The microspheres were further used as the fluorescent sensor for the detection of Fe 3+ . Fluorescence study showed high sensing sensitivity and selectivity of the microspheres, and the limit of detection was determined as 0.076 μM for Fe 3+ . Active amino groups on the surface could efficiently improve the detection sensitivity of Fe 3+ . Moreover, highly crosslinked organic-inorganic hybrid structure was beneficial to the photostability and thermostability, enabled the microspheres to be possible for constructing practicable sensors. This work is expected to inspire the design of advanced polyphosphazene-based fluorescent sensors for applications in analytical detection.

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“…Crosslinked nanogels have better stability than micelles and liposomes, which can prevent burst release during circulation, thus improving the tumor accumulation and drug-delivery efficiency. Some nanogels were reported to had higher accumulation in a tumor site compared with other major organs including liver and spleen [ 60 , 74 ], which was seldom reported for micelles and liposomes [ 102 ]. In addition, fluorophores can be easily conjugated onto the surface of nanogels by virtue of their multifunctionality.…”

Section: Discussionmentioning

confidence: 99%

“…Activatable drug delivery system can release drug under specific environment, which can elevate the therapeutic efficacy and reduce side effect [ 101 ]. Meng et al designed a pH/GSH dual-stimuli-responsive nanogels for MRI-guided chemotherapy [ 74 ]. Fe 3 O 4 nanoparticles were served as the core of nanogels, while the shell was synthesized by crosslinking hexachlorocyclotriphosphazene (HCCP) with curcumin (CUR) and bis-(4-hydroxyphenyl)-disulfide (HPS).…”

Section: Crosslinked Nanogels For Cancer Diagnosis and Imaging-guimentioning

confidence: 99%

Recent Advances in Crosslinked Nanogel for Multimodal Imaging and Cancer Therapy

Zhou

Yang

et al. 2020

Polymers

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Nanomaterials have been widely applied in the field of cancer imaging and therapy. However, conventional nanoparticles including micelles and liposomes may suffer the issue of dissociation in the circulation. In contrast, crosslinked nanogels the structures of which are covalently crosslinked have better physiological stability than micelles and liposomes, making them more suitable for cancer theranostics. In this review, we summarize recent advances in crosslinked nanogels for cancer imaging and therapy. The applications of nanogels in drug and gene delivery as well as development of novel cancer therapeutic methods are first introduced, followed by the introduction of applications in optical and multimodal imaging, and imaging-guided cancer therapy. The conclusion and future direction in this field are discussed at the end of this review.

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pH/redox dual-stimuli-responsive cross-linked polyphosphazene nanoparticles for multimodal imaging-guided chemo-photodynamic therapy

Abstract: Multifunctional nanodrugs with the integration of precise diagnostic and effective therapeutic functions have shown great promise in improving the efficacy of cancer therapy.

Cited by 80 publications

References 43 publications

Efficacy-shaping nanomedicine by loading Calcium Peroxide into Tumor Microenvironment-responsive Nanoparticles for the Antitumor Therapy of Prostate Cancer

Efficacy-shaping nanomedicine by loading Calcium Peroxide into Tumor Microenvironment-responsive Nanoparticles for the Antitumor Therapy of Prostate Cancer

Facile synthesis of amino‐functionalized polyphosphazene microspheres and their application for highly sensitive fluorescence detection of Fe³⁺

Recent Advances in Crosslinked Nanogel for Multimodal Imaging and Cancer Therapy

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pH/redox dual-stimuli-responsive cross-linked polyphosphazene nanoparticles for multimodal imaging-guided chemo-photodynamic therapy

Abstract: Multifunctional nanodrugs with the integration of precise diagnostic and effective therapeutic functions have shown great promise in improving the efficacy of cancer therapy.

Cited by 80 publications

References 43 publications

Efficacy-shaping nanomedicine by loading Calcium Peroxide into Tumor Microenvironment-responsive Nanoparticles for the Antitumor Therapy of Prostate Cancer

Efficacy-shaping nanomedicine by loading Calcium Peroxide into Tumor Microenvironment-responsive Nanoparticles for the Antitumor Therapy of Prostate Cancer

Facile synthesis of amino‐functionalized polyphosphazene microspheres and their application for highly sensitive fluorescence detection of Fe3+

Recent Advances in Crosslinked Nanogel for Multimodal Imaging and Cancer Therapy

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Product

Resources

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Facile synthesis of amino‐functionalized polyphosphazene microspheres and their application for highly sensitive fluorescence detection of Fe³⁺