pH/redox responsive core cross-linked nanoparticles from thiolated carboxymethyl chitosan for in vitro release study of methotrexate

Cheng, Gao; Liu, Ting; Dang, Yinghua; Yu, Zhiyan; Wang, Wei; Guo, Jingjie; Zhang, Xueqiong; He, Guowei; Zheng, Hua; Yin, Yi; Kong, Xiangqi

doi:10.1016/j.carbpol.2014.05.012

Cited by 79 publications

(51 citation statements)

References 24 publications

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“…NPs of chitosan with CDS to which proteins were incorporated before polyelectrolyte complex formation have shown LE values above 80% [25,56]. Chitosan/triphosphate NPs or thiolated carboxymethyl chitosan NPs crosslinked with disulfide bounds designed for MTX encapsulation have shown LC values between 18% and 53% depending on the crosslinking density [57,58]. In those previous works, the NPs were formed in presence of MTX, showing LE values of 62% [57].…”

Section: Loading and Release Of Mtxmentioning

confidence: 99%

Glucose cryoprotectant affects glutathione-responsive antitumor drug release from polysaccharide nanoparticles

Curcio

Blanco-Fernandez

Costoya

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

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Section: Loading and Release Of Mtxmentioning

confidence: 99%

Glucose cryoprotectant affects glutathione-responsive antitumor drug release from polysaccharide nanoparticles

Curcio

Blanco-Fernandez

Costoya

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

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“…GSH level was higher and pH level was lower in the tumor region than in the normal tissues. 21 Therefore, GSH/pH dual-responsive controlled release has great potential for this drug delivery system. …”

Section: Determination Of the Drug Releasementioning

confidence: 99%

“…20,21 In a previous study, a type of multifunctional nanosheet based on manganese dioxide (MnO 2 ) was prepared, and it was shown that MnO 2 nanosheets could respond to a slightly acidic environment and high concentration of reduced GSH, which caused the degradation of MnO 2 into manganese ions enabling T 1 -weighted magnetic resonance imaging (MRI). 22 Decorating MnO 2 sheets on the surface of PLGA could bring the MRI function and controlled release function to the nanoplatform in the tumor sites.…”

Section: Introductionmentioning

confidence: 99%

Gold nanorod–based poly(lactic-co-glycolic acid) with manganese dioxide core–shell structured multifunctional nanoplatform for cancer theranostic applications

Wang¹,

Liu²,

Hao³

et al. 2017

IJN

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Recently, photothermal therapy has become a promising strategy in tumor treatment. However, the therapeutic effect was seriously hampered by the low tissue penetration of laser. Therefore, in this study, radiofrequency (RF) with better tissue penetration was used for tumor hyperthermia. First, one type of gold nanorods (AuNRs) suitable for RF hyperthermia was selected. Then, poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) loaded with AuNRs and docetaxel (DTX) (PLGA/AuNR/DTX) NPs were constructed. Finally, manganese dioxide (MnO 2 ) ultrathin nanofilms were coated on the surfaces of PLGA/AuNR/DTX NPs by the reduction of KMnO 4 to construct the PLGA/AuNR/DTX@MnO 2 drug delivery system. This drug delivery system can not only be used for the combined therapy of chemotherapy and RF hyperthermia but can also produce Mn 2+ to enable magnetic resonance imaging. Furthermore, the RF hyperthermia and the degradation of MnO 2 can significantly promote the controlled drug release in a tumor region. The in vitro and in vivo results suggested that the PLGA/AuNR/DTX@MnO 2 multifunctional drug delivery system is a promising nanoplatform for effective cancer theranostic applications.

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“…CMCS-MUA was synthesized though the amidation reaction between the amino group of CMCS and the terminal carboxyl group of MUAaccording to the relevant literature information [21]. In brief, the obtained and dried CMCS (0.1 g) was dissolved in distilled water (10 mL) while being stirred for 24 h. MUA dissolved in 5 mL of dimethylsulfoxide (DMSO) was treated with EDC•HCl and NHS for 45 min for the activation of carboxyl groups of MUA.…”

Section: Synthesis Of Carboxymethyl Chitosan-11-mercapto Undecanoic Amentioning

confidence: 99%

Glutathione-Responsive Carboxymethyl Chitosan Nanoparticles for Controlled Release of Herbicides

Yu¹,

Sun²,

Hu³

et al. 2015

MSA

Self Cite

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Glutathione-responsive carboxymethyl chitosan nanoparticles cross-linked with disulfide bonds were developed for controlled release of herbicides. The nanoparticles were synthesized by selfassembly of amphiphilic carboxymethyl chitosan derivative (CMCS-MUA) in aqueous solution and subsequently producing disulfide cross-linking bonds by ultrasonic treatment. TEM showed that the nanoparticles had a spherical core-shell configuration with a size of about 250 nm. Assessment of stability of the nanoparticles (considering mean diameter, polydispersity, and Zeta potential) was conducted over a period of three months, and the nanoparticles were found to be stable in solution. Herbicide-loaded nanoparticles were prepared using diuron as a model herbicide. In vitro release study revealed that diuron can be released from nanoparticles in a controlled manner depended on the glutathione concentration. Herbicidal activity assays performed with preemergence treatment of target species (Echinochloa crusgalli) showed the effectiveness of diuron-loaded nanoparticles. Assays with nontarget species (Zea mays) showed that the diuronloaded nanoparticles did not affect plant growth. The results indicate that the glutathioneresponsive nanoparticles prepared in this work will be a promising candidate for controlled release of herbicides in agriculture.

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pH/redox responsive core cross-linked nanoparticles from thiolated carboxymethyl chitosan for in vitro release study of methotrexate

Cited by 79 publications

References 24 publications

Glucose cryoprotectant affects glutathione-responsive antitumor drug release from polysaccharide nanoparticles

Glucose cryoprotectant affects glutathione-responsive antitumor drug release from polysaccharide nanoparticles

Gold nanorod–based poly(lactic-co-glycolic acid) with manganese dioxide core–shell structured multifunctional nanoplatform for cancer theranostic applications

Glutathione-Responsive Carboxymethyl Chitosan Nanoparticles for Controlled Release of Herbicides

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pH/redox responsive core cross-linked nanoparticles from thiolated carboxymethyl chitosan for in vitro release study of methotrexate

Cited by 79 publications

References 24 publications

Glucose cryoprotectant affects glutathione-responsive antitumor drug release from polysaccharide nanoparticles

Glucose cryoprotectant affects glutathione-responsive antitumor drug release from polysaccharide nanoparticles

Gold nanorod&ndash;based poly(lactic-co-glycolic acid) with manganese dioxide core&ndash;shell structured multifunctional nanoplatform for cancer theranostic applications

Glutathione-Responsive Carboxymethyl Chitosan Nanoparticles for Controlled Release of Herbicides

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Product

Resources

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Gold nanorod–based poly(lactic-co-glycolic acid) with manganese dioxide core–shell structured multifunctional nanoplatform for cancer theranostic applications