pH-Responsive Capsules Engineered from Metal-Phenolic Networks for Anticancer Drug Delivery

Yuan, Ping; Guo, Junling; Ejima, Hirotaka; Chen, Xi; Richardson, Joseph J.; Sun, Huanli; Caruso, Frank

doi:10.1002/smll.201403343

Cited by 235 publications

(214 citation statements)

References 37 publications

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“…[ 40 ] The release of siRNA from the TA coated carrier/siRNA complex (denoted as MNC@LPMSA@siRNA@TA) also follows a pH-dependent behavior ( Figure S10, Supporting Information). After 24 h of incubation at pH 7 and pH 5, the residual siRNA in the carriers is 44% and 19%, respectively.…”

Section: Loading Capacity and Protection Of Sirnamentioning

confidence: 94%

“…In contrast to previous carrier coating strategies using lipid bilayer or cationic polymers, [ 4,8,30,41 ] this TA coating has been featured by high biocompatibility, availability to various substrates, facile one-step preparation and pH-dependent decomposition. [ 40,42,43 ] In this study, the successful coating of TA onto the nanoparticles is fi rst confi rmed by FTIR, X-ray photoelectron spectroscopy (XPS), thermogravimetric analysis ( Figure S7, Supporting Information). The TA coated sample shows additional C-H adsorption peaks in 1300-1500 cm −1 range of FTIR spectrum.…”

Section: Loading Capacity and Protection Of Sirnamentioning

confidence: 99%

“…[ 40 ] By simply mixing solutions containing Al 3+ ions and TA with the siRNA loaded nanoparticles, and adjusting the reaction pH, the surface coating is formed in minutes. In contrast to previous carrier coating strategies using lipid bilayer or cationic polymers, [ 4,8,30,41 ] this TA coating has been featured by high biocompatibility, availability to various substrates, facile one-step preparation and pH-dependent decomposition.…”

Section: Loading Capacity and Protection Of Sirnamentioning

confidence: 99%

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Magnetic Core–Shell Silica Nanoparticles with Large Radial Mesopores for siRNA Delivery

Xiong

Tang³

et al. 2016

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102

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A novel type of magnetic core-shell silica nanoparticles is developed for small interfering RNA (siRNA) delivery. These nanoparticles are fabricated by coating super-paramagnetic magnetite nanocrystal clusters with radial large-pore mesoporous silica. The amine functionalized nanoparticles have small particle sizes around 150 nm, large radial mesopores of 12 nm, large surface area of 411 m(2) g(-1) , high pore volume of 1.13 cm(3) g(-1) and magnetization of 25 emu g(-1) . Thus, these nanoparticles possess both high loading capacity of siRNA (2 wt%) and strong magnetic response under an external magnetic field. An acid-liable coating composed of tannic acid can further protect the siRNA loaded in these nanoparticles. The coating also increases the dispersion stability of the siRNA-loaded carrier and can serve as a pH-responsive releasing switch. Using the magnetic silica nanoparticles with tannic acid coating as carriers, functional siRNA has been successfully delivered into the cytoplasm of human osteosarcoma cancer cells in vitro. The delivery is significantly enhanced with the aid of the external magnetic field.

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Section: Loading Capacity and Protection Of Sirnamentioning

confidence: 94%

Section: Loading Capacity and Protection Of Sirnamentioning

confidence: 99%

Section: Loading Capacity and Protection Of Sirnamentioning

confidence: 99%

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Magnetic Core–Shell Silica Nanoparticles with Large Radial Mesopores for siRNA Delivery

Xiong

Tang³

et al. 2016

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102

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“…Capsules with the metal-phenolic network (MPN) shell were synthesized by the complexation between the organic ligand deposited on removable -sacrificial templates and inorganic metal ions as a cross-linker that produced robust nanoscale coordination layers [348,349]. Such films are structurally rigid but could respond to external stimuli and they can be degraded under cytocompatible physiological conditions.…”

Section: Bio-inspired Poly(dopamine) Capsules With a Fluorescent Shellmentioning

confidence: 99%

Fluorescent Dyes Used in Polymer Carriers as Imaging Agents in Anticancer Therapy

Miksa¹

2016

Med chem (Los Angeles)

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This review highlights the role of fluorescent dyes as active "molecular photoswiches" focusing on the application in bioimaging and anticancer therapies in the field of therapeutic delivery. The author describes the development of prodrugs targeted to specific cell types and polymeric nanocarriers (capsules, micelles and silica nanoparticles) used as fluorescent probes which offer advantages in the integration of "smart" features of fluorescent dyes into synthetic materials. The incorporation of biologically responsive components that cleave upon changes in pH or light irradiation is fundamental to the successful design of such carriers with capabilities to load and release therapeutics specifically at a target site.

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“…28,29 Due to diverse structural and functional properties of TA, combined with its chelation ability, metal-TA coordination complexes could form three-dimensional films on a range of substrates. 30,31 The cleavage of the coordination bonds based on metal and TA is sensitive to variations in external pH, which could impact the delivery system by the pH-responsive release of the drug under acidic conditions. In our previous work, we have investigated designable coordination bonding-based metal-TA architecture on zein NPs.…”

Section: Introductionmentioning

confidence: 99%

Tailoring stimuli-responsive delivery system driven by metal–ligand coordination bonding

Liang¹,

Zhou²,

He³

et al. 2017

IJN

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In this study, a novel coordination bonding system based on metal–tannic acid (TA) architecture on zein/carboxymethyl chitosan (CMCS) nanoparticles (NPs) was investigated for the pH-responsive drug delivery. CMCS has been reported to coat on zein NPs as delivery vehicles for drugs or nutrients in previous studies. The cleavage of either the “metal–TA” or “NH 2 –metal” coordination bonds resulted in significant release of guest molecules with high stimulus sensitivity, especially in mild acidic conditions. The prepared metal–TA-coated zein/CMCS NPs (zein/CMCS-TA/metal NPs) could maintain particle size in cell culture medium at 37°C, demonstrating good stability compared with zein/CMCS NPs. In vitro release behavior of doxorubicin hydrochloride (DOX)-loaded metal–TA film-coated zein/CMCS NPs (DOX-zein/CMCS-TA/metal NPs) showed fine pH responsiveness tailored by the ratio of zein to CMCS as well as the metal species and feeding concentrations. The blank zein/CMCS-TA/metal NPs (NPs-TA/metal) were of low cytotoxicity, while a high cytotoxic activity of DOX-zein/CMCS-TA/metal NPs (DOX-NPs-TA/metal) against HepG2 cells was demonstrated by in vitro cell assay. Confocal laser scanning microscopy (CLSM) and flow cytometry were combined to study the uptake efficiency of DOX-NPs or DOX-NPs-TA/metal. This system showed significant potential as a highly versatile and potent platform for drug delivery.

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pH-Responsive Capsules Engineered from Metal-Phenolic Networks for Anticancer Drug Delivery

Cited by 235 publications

References 37 publications

Magnetic Core–Shell Silica Nanoparticles with Large Radial Mesopores for siRNA Delivery

Magnetic Core–Shell Silica Nanoparticles with Large Radial Mesopores for siRNA Delivery

Fluorescent Dyes Used in Polymer Carriers as Imaging Agents in Anticancer Therapy

Tailoring stimuli-responsive delivery system driven by metal–ligand coordination bonding

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pH-Responsive Capsules Engineered from Metal-Phenolic Networks for Anticancer Drug Delivery

Cited by 235 publications

References 37 publications

Magnetic Core–Shell Silica Nanoparticles with Large Radial Mesopores for siRNA Delivery

Magnetic Core–Shell Silica Nanoparticles with Large Radial Mesopores for siRNA Delivery

Fluorescent Dyes Used in Polymer Carriers as Imaging Agents in Anticancer Therapy

Tailoring stimuli-responsive delivery system driven by metal&ndash;ligand coordination bonding

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Tailoring stimuli-responsive delivery system driven by metal–ligand coordination bonding