pH-responsive interpenetrating network hydrogel beads of poly(acrylamide)-g-carrageenan and sodium alginate for intestinal targeted drug delivery: Synthesis, in vitro and in vivo evaluation

Kulkarni, Raghavendra V.; Boppana, Rashmi; Mohan, G. Krishna; Mutalik, Srinivas; Kalyane, Navanath V.

doi:10.1016/j.jcis.2011.10.025

Cited by 158 publications

(68 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…pH responsive hydrogel beads obtained by grafting polyacrylamide onto kappacarrageenan and sodium alginate (SA), for targeting ketoprofen to the intestine have been reported by Kulkarni and co [211]. The grafted polyacrylamide-carrageenan was synthesised by free-radical polymerization with alkaline hydrolysis whilst the drug loaded hydrogels were obtained by ionic gelation and covalent crosslinking and showed amorphous conversion of the drug within the beads as analysed using differential scanning calorimetry and X-ray diffraction.…”

Section: Swelling and Drug Release Characterisation Studies On The Hymentioning

confidence: 93%

Polysaccharide Based Formulations for Mucosal Drug Delivery: A Review

Boateng

Okeke²,

Khan³

2015

CPD

View full text Add to dashboard Cite

There has been increased interest in novel drug delivery systems to be administered via mucosal routes as an alternative to the currently used traditional routes such as parenteral (injections) and oral routes of administration. This is due to the several advantages they offer including avoiding first pass metabolism in the liver for oral administration and local activity which avoids the need for high systemic doses. To achieve the foregoing objectives, bioadhesive vehicles are required that ensure prolonged residence time to achieve systemic bioavailability via substantial drug absorption or significant drug concentration for local action.The drug delivery system is also required to be non-deleterious to the site of application and be well tolerated by vulnerable groups such as paediatric and geriatric patients. These essential characteristics are mainly satisfied by naturally occurring polymers, including polysaccharide based polymers which have the advantage of biocompatibility, biodegradability and therefore safety. This review discusses various bioadhesive polymers of polysaccharide origin formulated into a variety of dosage forms for drug delivery via the body's mucosal (moist) surfaces including ocular, oral (buccal and sublingual), nasal, gastrointestinal and vaginal mucosa, as well as moist wound sites. The anatomy and / or physiology of each site, coupled with the unique challenges each poses, the strategies employed for ensuring therapeutic efficacy, as well as the current state of the art will also be covered.

show abstract

Section: Swelling and Drug Release Characterisation Studies On The Hymentioning

confidence: 93%

Polysaccharide Based Formulations for Mucosal Drug Delivery: A Review

Boateng

Okeke²,

Khan³

2015

CPD

View full text Add to dashboard Cite

show abstract

“…Poly(acrylamide)-graft-κ-carrageenan (PAAm-g-CG) and sodium alginate (SA) Ketoprofen [78] In vitro, Release of drug into rat stomach.…”

Section: Hydrogelsmentioning

confidence: 99%

Functionalized Polymers for Enhance Oral Bioavailability of Sensitive Molecules

et al. 2016

View full text Add to dashboard Cite

Currently, many sensitive molecules have been studied for effective oral administration. These substances are biologically active compounds that mainly suffer early degradation in the gastrointestinal tract (GIT) and physicochemical instability, inactivation and poor solubility and permeability. The sensibility of the biomolecules has limited their oral administration in the body and today is an important research topic to achieve desired effects in medicine field. Under this perspective, various enhancement approaches have been studied as alternatives to increase their oral bioavailability. Some of these strategies include functionalized polymers to provide specific useful benefits as protection to the intestinal tract by preventing its degradation by stomach enzymes, to increase their absorption, permeability, stability, and to make a proper release in the GIT. Due to specific chemical groups, shapes and sizes, morphologies, mechanical properties, and degradation, recent advances in functionalized polymers have opened the door to great possibilities to improve the physicochemical characteristics of these biopharmaceuticals. Today, many biomolecules are found in basic studies, preclinical steps, and others are late stage clinical development. This review summarizes the contribution of functionalized polymers to enhance oral bioavailability of sensitive molecules and their application status in medicine for different diseases. Future trends of these polymers and their possible uses to achieve different formulation goals for oral delivery are also covered in this manuscript.

show abstract

“…Even that so, the leakage of enzymes still occurred at low agitation speed. According to Kulkarni et al [11], the leakage of enzymes may be due to the swelling of the alg-clay beads. The swelling behavior was occurred when the beads tend to absorb water in order to fill the void regions of the polymer network within the beads that remain dehydrated until they reach the equilibrium state.…”

Section: B Beads Morphologymentioning

confidence: 99%

Effect of Agitation Speed for Enzymatic Hydrolysis of Tapioca Slurry Using Encapsulated Enzymes in an Enzyme Bioreactor

Rahim¹,

Sulaiman²,

Hamid³

et al. 2015

IJCEA

View full text Add to dashboard Cite

Abstract-Agitation speed is an important factor in the industrial application for the mixing efficiency in order to increase productivity. In this study, the effect of agitation speed was investigated in a stirred bioreactor for hydrolysis of tapioca slurry into glucose by using encapsulated enzymes within calcium alginate-clay (alg-clay) beads. The hydrolysis process was tested at various agitation speeds from 40 to 200 rpm. The stability of alg-clay beads was examined in term of morphology of beads, enzyme leaching behavior and enzymes activity. The morphology of the alg-clay beads was investigated by Field Emission Scanning Electron Microscopy (FESEM). It was found that vigorous speed ruptured the beads structure. The result also showed that by increasing the agitation speed, the leakage of enzymes also increased. Therefore, it can be concluded that there was a strong correlation between the speed of agitation and the beads morphology. The optimum agitation speed which gave the highest amount of enzymes activity was 120 rpm.

show abstract

pH-responsive interpenetrating network hydrogel beads of poly(acrylamide)-g-carrageenan and sodium alginate for intestinal targeted drug delivery: Synthesis, in vitro and in vivo evaluation

Cited by 158 publications

References 33 publications

Polysaccharide Based Formulations for Mucosal Drug Delivery: A Review

Polysaccharide Based Formulations for Mucosal Drug Delivery: A Review

Functionalized Polymers for Enhance Oral Bioavailability of Sensitive Molecules

Effect of Agitation Speed for Enzymatic Hydrolysis of Tapioca Slurry Using Encapsulated Enzymes in an Enzyme Bioreactor

Contact Info

Product

Resources

About