pH‐Responsive Molecularly Imprinted Polymers

Kanekiyo, Yasumasa; Naganawa, Ryuichi; Tao, Hiroaki

doi:10.1002/anie.200351381

Cited by 95 publications

(55 citation statements)

References 9 publications

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“…Tao et al 280 firstly reported a novel pH-responsive MIP using amylose as the host matrix and acrylic acid as the functional monomer. As a result, they found that the rebinding ability …”

mentioning

confidence: 99%

Molecular imprinting: perspectives and applications

et al. 2016

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a Molecular imprinting technology (MIT), often described as a method of making a molecular lock to match a molecular key, is a technique for the creation of molecularly imprinted polymers (MIPs) with tailor-made binding sites complementary to the template molecules in shape, size and functional groups. Owing to their unique features of structure predictability, recognition specificity and application universality, MIPs have found a wide range of applications in various fields. Herein, we propose to comprehensively review the recent advances in molecular imprinting including versatile perspectives and applications, concerning novel preparation technologies and strategies of MIT, and highlight the applications of MIPs. The fundamentals of MIPs involving essential elements, preparation procedures and characterization methods are briefly outlined.Smart MIT for MIPs is especially highlighted including ingenious MIT (surface imprinting, nanoimprinting, etc.), special strategies of MIT (dummy imprinting, segment imprinting, etc.) and stimuli-responsive MIT (single/dual/ multi-responsive technology). By virtue of smart MIT, new formatted MIPs gain popularity for versatile applications, including sample pretreatment/chromatographic separation (solid phase extraction, monolithic column chromatography, etc.) and chemical/biological sensing (electrochemical sensing, fluorescence sensing, etc.). Finally, we propose the remaining challenges and future perspectives to accelerate the development of MIT, and to utilize it for further developing versatile MIPs with a wide range of applications (650 references).

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“…Tao et al 280 firstly reported a novel pH-responsive MIP using amylose as the host matrix and acrylic acid as the functional monomer. As a result, they found that the rebinding ability …”

mentioning

confidence: 99%

Molecular imprinting: perspectives and applications

et al. 2016

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“…[16] These intelligent gels can not only catalyze a chemical reaction but their catalysis can also be switched on and off by external stimuli. Recently, several attempts have been reported to obtain stimuli-sensitive imprinted hydrogels that change their rebinding abilities toward the template molecule in response to temperature, [17] pH, [18] and photo irradiation. [19] We have previously developed poly-N-isopropylacrylamide (pNIPAM)-based protein-imprinted polymer gels that can sensitively respond not only to external stimuli, such as temperature and salt concentration, but also to the corresponding template protein with significant volume shrinking.…”

mentioning

confidence: 99%

pH‐Sensitive Water‐Soluble Nanospheric Imprinted Hydrogels Prepared as Horseradish Peroxidase Mimetic Enzymes

et al. 2010

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“…This was demonstrated by Kanekiyo et al 18 for acryloylamylose copolymerized with acrylic acid producing an inclusion complex binding site that reversibly bound bisphenol-A depending on the pH of the solution. Alvarez-Lorenzo et al verified reversible adsorption of calcium ions 19 and aluminum ions 20 by imprinted temperature sensitive gels.…”

Section: Introduction: Molecular Recognition In Intelligent Drug Delimentioning

confidence: 85%

Recognitive biomimetic networks with moiety imprinting for intelligent drug delivery

Byrne

Hilt

Peppas

2007

J Biomedical Materials Res

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Molecular imprinting techniques have been developed for the preparation of biomimetic polymer networks that can recognize a general moiety, D-glucose, and the novel evaluation of loading and release of a larger molecule with glucose as an integral part of its structure [i.e., fluorescently tagged glucose (2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxy-glucose) or 2-NBDG]. Poly(acrylamide-co-poly(ethylene glycol)dimethacrylate) networks with varying crosslinking monomer percentages (80, 67, and 30%) and crosslinker lengths (average number of ethylene glycol units of 1, 4, and 14) were prepared and characterized using a novel fluorescent microscopy technique, which allowed for microscale observation of the dynamic binding and release of 2-NBDG within the polymer film. Experimental results indicate that tighter mesh-sized networks had increased affinity and capacity towards the glucose functionalized molecule as well as increased diffusional transport times, indicating the strong potential to load significantly higher amounts of therapeutic within intelligent carriers as well as control and extend the rate of release via macromolecular structure.

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pH‐Responsive Molecularly Imprinted Polymers

Cited by 95 publications

References 9 publications

Molecular imprinting: perspectives and applications

Molecular imprinting: perspectives and applications

pH‐Sensitive Water‐Soluble Nanospheric Imprinted Hydrogels Prepared as Horseradish Peroxidase Mimetic Enzymes

Recognitive biomimetic networks with moiety imprinting for intelligent drug delivery

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