pH-responsive nanocatalyst for enhancing cancer therapy via H₂O₂ homeostasis disruption and disulfiram sensitization

Abstract

Due to the powerful redox homeostasis and inefficient of monotherapy, chemodynamic therapy (CDT) is clinically limited. Despite great efforts, the design of CDT nanosystems with specific H2O2 homeostasis and effective...

Engineering of a double targeting nanoplatform to elevate ROS generation and DSF anticancer activity

“…It can inhibit CAT activity and consume GSH for enhanced CDT, which has been confirmed in recent studies. 17 In a previous study, we successfully synthesized CaO 2 @MAF-DSF@HA and reinforced the CDT synergistic CT. 18 Nevertheless, it remains challenging due to insufficient Cu 2+ concentration and limited reactive oxygen species (ROS) generation. In recent years, mitochondria targeting has been considered an effective approach to elevate the ROS level.…”

Modulation of two-dimensional palladium nanozyme activity to enhance chemodynamic/photothermal combined therapy for melanoma

“…Nanomaterials have demonstrated significant potential in improving tumor treatment efficiency and biocompatibility, including chemotherapy, 1 radiotherapy, 2 thermal ablation, 3 reactive oxygen species (ROS) therapy, 4 and immunotherapy. 5 Among them, ROS-based treatment has gained widespread attention due to its low drug resistance and strong oxidative lethality towards cells and even specific subcellular structures.…”