pH-Responsive Nanoemulsions for Controlled Drug Release

Liu, Feng; Lin, Shudong; Zhang, Zuoquan; Hu, Jiwen; Liu, Guojun; Tu, Yuanyuan; Yang, Yang; Zou, Hailiang; Mo, Yangmiao; Miao, Lei

doi:10.1021/bm4018484

Cited by 42 publications

(23 citation statements)

References 42 publications

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“…If the capsule wall had disintegrated when the pH was changed, the diameters of the capsules observedb yD LS would increaset oagreater degree and even reach the micrometer scale. [30] The moderate increase in the value of the diameters indicatedt hat the capsule walls remained stable. The increase in the diameters can be attributed to the cationicP DEAEMA chains becoming solvated by water and stretching outwardlyf rom the PCEMA wall, thus yielding the increased hydrodynamic diameters.…”

Section: Nanoporousc Apsule Formationmentioning

confidence: 98%

pH‐Responsive Porous Nanocapsules for Controlled Release

Song

Wei

et al. 2017

Chemistry A European J

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In this work pH-responsive porous nanocapsules have been successfully prepared from at ernary graft copolymer,p oly(glycidyl methacrylate)-g-[poly(2-cinnamoyloxyethyl methacrylate)-r-poly(ethyleneg lycol) methyl ether-r-poly(2-diethylaminoethyl methacrylate)] or PGMA-g-(PCEMA-r-MPEG-r-PDEAEMA).T he graft copolymersw eref abricated by grafting three types of polymer chains onto the backbone polymer by using click chemistry.T hese ternary copolymers underwents elf-assembly to form vesicles in aD MF/water solvent mixture. While the MPEG chains served as the corona and stabilized the vesicles, the vesicle wall was composed of ad ominant PCEMA continuous phase that was interspersed by PDEAEMA domains. After photo-cross-linking, the PDEAEMA domains were embedded in the structurally locked PCEMA wall. By decreasing the pH of the externals olution, we were able to trigger the release of encapsulated pyrene due to the capsule wall becoming porousa saresult of the PDEAEMA chains bearing positivelyc harged amine groups stretching into the water.W hile these pH-responsive porousn anocapsulese xhibited potential applications in drug delivery,d etection and catalysis, the strategy reported in this contribution also represented an ew paradigm for the design and preparation of other novel stimuli-responsive porousnanocapsules.

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Section: Nanoporousc Apsule Formationmentioning

confidence: 98%

pH‐Responsive Porous Nanocapsules for Controlled Release

Song

Wei

et al. 2017

Chemistry A European J

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“…To the best of our knowledge, most of the existing graft copolymers are not completely degradable or environmentally sensitive, and hardly any reversibly crosslinkable graft copolymers have been synthesized. The lack of these properties limits their use as DDSs.…”

Section: Introductionmentioning

confidence: 99%

Dual‐responsive crosslinked micelles of a multifunctional graft copolymer for drug delivery applications

Feng

et al. 2017

J. Polym. Sci. Part A: Polym. Chem.

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A novel multifunctional amphiphilic graft copolymer has been synthesized consisting of a biodegradable poly(l‐aspartic acid) backbone that was decorated by water‐soluble poly(ethylene glycol) (PEG) and pH‐responsive poly(N,N‐diethylaminoethyl methacrylate) (PDEAEMA) side‐chains as well as thiol pendant groups. This graft copolymer together with doxorubicin (DOX) formed micelles in water at pH = 10.0 with PDEAEMA and DOX acting as the core and PEG serving as the micellar corona. Upon oxidation, the thiol groups dimerized to form disulfide bonds, thus “locking in” the micellar structure. These crosslinked micelles expanded as the pH was decreased from 7.4 to 5.0 or upon the addition, at pH = 7.4, of glutathione (GSH), a thiol‐containing oligopeptide that is present in cancerous cells and cleaves disulfide bonds. At pH = 5.0, GSH addition triggered the disassembly of the micelles. The expansion and disassembly of the micelles have been determined via in vitro experiments to evaluate their DOX release behavior. More importantly, the graft copolymer micelles could enter cells by means of endocytosis and deliver DOX to the nuclei of ovarian cancer BEL‐7402 cells. Thus, this polymer and its micelles are promising candidates for drug delivery applications. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 1536–1546

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“…Production of long-lived, kinetically stable oil-in-water dispersions (so-called nanoemulsions) has received growing interest in recent years (Nakajima et al, 1993;Tadros et al, 2004;Solans et al, 2005;Yu et al, 2012;Fryd & Mason, 2013;Liu et al, 2014;Cao et al, 2015). These dispersions have promising applications in materials science, pharmaceutics, food sciences and personal care products (Sadurní et al, 2005;Srivastava et al, 2006;Guglielmini, 2008;Wang et al, 2009;Klang et al, 2011;Ostertag et al, 2012;Saberi et al, 2013;Feng et al, 2014,), as well as potential roles in ‡ Present address: 1202 Cherokee Ave., West Saint Paul, MN 55118, U.S.A. § 612-625-1822; fax: +1 612-626-7246; e-mail: mccormic@umn.edu drug delivery systems needing control of size, stability (Taylor & Ottewill, 1994;Joos et al, 2014), bio-availability (Margulis et al, 2014) and active agents (Pouton, 1997;Saberi et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Cryogenic transmission electron microscopy study: preparation of vesicular dispersions by quenching microemulsions

Lee

Morrison

Zhang

et al. 2016

Journal of Microscopy

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We previously showed that long-lived nanoemulsions, seeming initially vesicular, might be prepared simply by diluting and cooling (quenching) warm microemulsions with n-hexadecane with precooled water. In this paper, we confirm that these systems are vesicular dispersions when fresh, and they can be made with similar structures and compositional dependence using alkanes with chain lengths ranging from octane to hexadecane. The nanostructures of fresh nanoemulsions are imaged with cryogenic transmission electron microscopy (cryo-TEM). We confirm that water-continuous microemulsions give simple dispersions of vesicles (sometimes unilamellar), typically less than 100 nm in diameter; these systems can avoid separation for over 2 months. Selected samples were also prepared using halogenated alkanes to create additional contrast in the cryo-TEM, allowing us to confirm that the oil is located in the observed vesicular structures.

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pH-Responsive Nanoemulsions for Controlled Drug Release

Cited by 42 publications

References 42 publications

pH‐Responsive Porous Nanocapsules for Controlled Release

pH‐Responsive Porous Nanocapsules for Controlled Release

Dual‐responsive crosslinked micelles of a multifunctional graft copolymer for drug delivery applications

Cryogenic transmission electron microscopy study: preparation of vesicular dispersions by quenching microemulsions

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