pH-Responsive nanofiber buttresses as local drug delivery devices

Altinbasak, Ismail; Kocak, Salli; Colby, Aaron H.; Alp, Yasin; Sanyal, Rana; Grinstaff, Mark W.; Sanyal, Amitav

doi:10.1039/d2bm01199a

Cited by 16 publications

(9 citation statements)

References 60 publications

(97 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Variations in pH across different parts of the human body inspire the use of pH-sensitive materials, like the Eudragit polymer family, for targeted drug delivery [ 96 , 97 ]. For instance, the gastric juice pH ranges from 0.9 to 1.8, contrasting with the intestinal tract’s pH of around 7.…”

Section: Drug Release Modes Of Drug-loaded Nanofibersmentioning

confidence: 99%

Application of Electrospun Drug-Loaded Nanofibers in Cancer Therapy

Yang,

Zhang,

Liang

et al. 2024

Polymers

View full text Add to dashboard Cite

In the 21st century, chemotherapy stands as a primary treatment method for prevalent diseases, yet drug resistance remains a pressing challenge. Utilizing electrospinning to support chemotherapy drugs offers sustained and controlled release methods in contrast to oral and implantable drug delivery modes, which enable localized treatment of distinct tumor types. Moreover, the core–sheath structure in electrospinning bears advantages in dual-drug loading: the core and sheath layers can carry different drugs, facilitating collaborative treatment to counter chemotherapy drug resistance. This approach minimizes patient discomfort associated with multiple-drug administration. Electrospun fibers not only transport drugs but can also integrate metal particles and targeted compounds, enabling combinations of chemotherapy with magnetic and heat therapies for comprehensive cancer treatment. This review delves into electrospinning preparation techniques and drug delivery methods tailored to various cancers, foreseeing their promising roles in cancer treatment.

show abstract

Section: Drug Release Modes Of Drug-loaded Nanofibersmentioning

confidence: 99%

Application of Electrospun Drug-Loaded Nanofibers in Cancer Therapy

Yang,

Zhang,

Liang

et al. 2024

Polymers

View full text Add to dashboard Cite

show abstract

“…In today's technological milieu, it is commonly acknowledged that stimuli‐sensitive systems with controlled drug release are feasible. Both exogenous and endogenous stimuli are used for the sake of this objective, however, the most frequent trigger is endogenous pH 184 . Functionalizing the fundamental pH‐responsive polymers with chemical moieties that render these polymers dually responsive to a variety of stimuli makes the targeting efficiency more precise.…”

Section: Applications Of Polyelectrolytes In Drug Deliverymentioning

confidence: 99%

“…Both exogenous and endogenous stimuli are used for the sake of this objective, however, the most frequent trigger is endogenous pH. 184 Functionalizing the fundamental pH-responsive polymers with chemical moieties that render these polymers dually responsive to a variety of stimuli makes the targeting efficiency more precise. This phenomenon has been investigated by Xu et al A pH and glutathione-triggered drug delivery system against breast cancer was developed by conjugating doxorubicin with polyethylene glycol linked through disulfide bonds and cis-aconitic anhydride.…”

Section: Drug Delivery To the Malignant Tissuesmentioning

confidence: 99%

pH‐responsive polymers for drug delivery: Trends and opportunities

Singh,

Nayak

2023

Journal of Polymer Science

View full text Add to dashboard Cite

Polymer science has applications in biomedical engineering, prosthetics, surgical implants, and prospective pharmaceutical excipients for drug delivery. “Intelligent or Smart Polymers” are created for drug targeting either by derivatization of natural polymers or controlled radical polymerization of electrolytes. Their mode of action is governed by the environmental stimuli viz. temperature, pH, ionic concentration, magnetism, and so on. pH‐responsive polymers, because of their self‐assembling behavior, alter their solubility, conformation, surface activity, and hydrophilicity when exposed to a specific pH. The physiological pH varies from acidic nuclei to alkaline cytoplasm and highly acidic gastric juice to slightly alkaline plasma; thus, various polymers are under study for delivering small molecules, genes, peptides, enzymes, growth factors, and antibodies. The non‐invasive drug delivery routes like oral, ocular, nasal, pulmonary, transdermal, and rectal routes can be explored for targeting recombinant proteins, monoclonal antibodies, and small molecules with particular emphasis on the individual's physiological and pathological state. Further, these polymers can be designed into various architectures like dendrimers, liposomes, micelles, and metallic nanoparticles that can serve as drug reservoirs for sustaining drug release. The challenges in this field are the selection of biocompatible polymers with ease of synthesis and scale‐up, ensuring effective drug‐loading, and stability aspects, producing robust pharmacological data, and timely regulatory approvals. This review exclusively explores the physicochemical characteristics of pH‐responsive polymers, their categorization, various architectural entities, recent studies and patents, and their emerging applications concerning specific diseases.

show abstract

“…Ismail Altinbasak et al reported a pH-responsive nanofiber scaffold synthesized by electrospinning using a polymer composed of a hydrolysable, acid-sensitive, and side-chain trimethoxybenzaldehyde-protected acrylate main chain. At physiologically relevant pH = 6.5 in the extracellular tumor environment, the scaffold transitions from a hydrophobic state to a hydrophilic state, leading to hydrolysis of the side chains and an approximately three-fold increase in fiber diameter, thereby releasing the drug encapsulated within the nanofiber scaffold [ 254 ].…”

Section: Multiresponse Intelligent Drug Delivery Systems Based On Nan...mentioning

confidence: 99%

Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing

Jiang

Zheng

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

Nanofiber scaffolds have emerged as a revolutionary drug delivery platform for promoting wound healing, due to their unique properties, including high surface area, interconnected porosity, excellent breathability, and moisture absorption, as well as their spatial structure which mimics the extracellular matrix. However, the use of nanofibers to achieve controlled drug loading and release still presents many challenges, with ongoing research still exploring how to load drugs onto nanofiber scaffolds without loss of activity and how to control their release in a specific spatiotemporal manner. This comprehensive study systematically reviews the applications and recent advances related to drug-laden nanofiber scaffolds for skin-wound management. First, we introduce commonly used methods for nanofiber preparation, including electrostatic spinning, sol–gel, molecular self-assembly, thermally induced phase separation, and 3D-printing techniques. Next, we summarize the polymers used in the preparation of nanofibers and drug delivery methods utilizing nanofiber scaffolds. We then review the application of drug-loaded nanofiber scaffolds for wound healing, considering the different stages of wound healing in which the drug acts. Finally, we briefly describe stimulus-responsive drug delivery schemes for nanofiber scaffolds, as well as other exciting drug delivery systems.

show abstract

pH-Responsive nanofiber buttresses as local drug delivery devices

Abstract: Electrospun nanofibers are a 3D scaffold of choice for many drug delivery devices due to their high surface area, significant capacity for drug payload, ease of in situ placement, and...

Cited by 16 publications

References 60 publications

Application of Electrospun Drug-Loaded Nanofibers in Cancer Therapy

Application of Electrospun Drug-Loaded Nanofibers in Cancer Therapy

pH‐responsive polymers for drug delivery: Trends and opportunities

Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing

Contact Info

Product

Resources

About