2017
DOI: 10.1016/j.colsurfb.2017.03.024
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pH-responsive poly (acrylic acid)-gated mesoporous silica and its application in oral colon targeted drug delivery for doxorubicin

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Cited by 132 publications
(72 citation statements)
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“…The topological surface area of DOX molecule is 2.06 nm 2 , and the hydrodynamic radius for DOX in water is ca. 1.5 nm (40); therefore, the DOX molecule fits into the pores of SBA-15 materials (41,42). This estimate was also confirmed by STEM with the corresponding EELS (cf.…”
Section: Discussionmentioning
confidence: 63%
“…The topological surface area of DOX molecule is 2.06 nm 2 , and the hydrodynamic radius for DOX in water is ca. 1.5 nm (40); therefore, the DOX molecule fits into the pores of SBA-15 materials (41,42). This estimate was also confirmed by STEM with the corresponding EELS (cf.…”
Section: Discussionmentioning
confidence: 63%
“…Furthermore, several research have been devoted to fabricating pH sensitive MSNs for oral chemotherapy because most of the anticancer drugs like doxorubicin (DOX) have poor oral bioavailability. Tian et al . used a simple “graft to” method capping MSNs with poly (acrylic acid) (PAA) to construct a novel pH‐triggered oral drug delivery system with a high drug loading capacity (785.7 mg/g) as well as excellent pH‐sensitivity and good biocompatibility (Figure ).…”
Section: Stimuli‐responsive Drug Delivery From Polymer‐brush‐grafted mentioning
confidence: 99%
“…Hydrogels sensitive to environmental changes have immense potential in various applications [93]. These materials have intensively been studied in the past years for their application in the field of biology and medicine [94], controlled [95] and targeted drug delivery [96], environmental protection [97] and many other applications [98][99][100]. Of all the stimuli mentioned above, the impact of temperature has been studied the most.…”
Section: (1) (2018) 79-91mentioning
confidence: 99%