pH-responsive poly(lactide-co-glycolide) nanoparticles containing near-infrared dye for visualization and hyaluronic acid for treatment of osteoarthritis

Zerrillo, Luana; Que, Ivo; Vepris, Olena; Morgado, Luis; Chan, Alan; Bierau, Katja; Li, Y.; Galli, F.; Bos, Erik; Censi, Roberta; Martino, Piera Di; Osch, Gerjo J.V.M. van; Cruz, Luis J.

doi:10.1016/j.jconrel.2019.07.031

Cited by 49 publications

(40 citation statements)

References 46 publications

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“…However, at a slightly acidic medium pH 5 a burst release was observed from Rh-PLGA-NPs@NH 4 in comparison to Rh-PLGA-NPs. The results might be attributed to the porous nature of PLGA which allows the H 3 O + in Rh-PLGA-NPs@NH 4 which reacts with NH 4 HCO 3 and produces NH 4 + , CO 2 and H 2 O (Zerrillo et al 2019 ). The reaction increase the rupture of Rh-PLGA-NPs@NH 4 due to high pressure resulting in burst release of Rh.…”

Section: Discussionmentioning

confidence: 99%

“…The solvent emulsion–evaporation procedure was applied for the synthesis of PLGA NPs loaded with Rh (Rh-PLGA-NPs) (Zerrillo et al 2019 ). Firstly the 2.5 mL of methanol solution having 10 mg of Rh was prepared, which was further added to the solution of PLGA (200 mg) in DCM.…”

Section: Methodsmentioning

confidence: 99%

“…As a result NH 4+ ion is generated along with H 2 O and CO 2 , rupturing the shell of NPs and causing the burst release of entrapped Rh. The solvent emulsion-evaporation procedure was applied for the synthesis of PLGA NPs loaded with Rh (Rh-PLGA-NPs) (Zerrillo et al 2019). Firstly the 2.5 mL of methanol solution having 10 mg of Rh was prepared, which was further added to the solution of PLGA (200 mg) in DCM.…”

Section: Rational Design Of Npsmentioning

confidence: 99%

“…One of the most prevalent disorders associated to joints is osteoarthritis (OA), which mainly affects the hand, hip and knee joints. (Zerrillo et al 2019). Mostly in osteoarthritis osteophyte formation, sub-chondral bone sclerosis, degeneration of articular cartilage, synovial inflammation occurs (Buckland-Wright 2004;Castaneda et al 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, the porous nature of PLGA-NP allows small molecules such as H 2 O and H 3 O + inside the NPs, enhancing the release of Rh. Hydrogen ions (H 3 O + ) present at high concentrations and at low pH, react with NH 4 HCO 3 in PLGA-NP to induce pH neutralization and result in the production of NH 4 + , CO 2 and H 2 O (Zerrillo et al 2019 ). This conversion caused damage to the PLGA-NPs structure with sudden release of cargo.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Rhein laden pH-responsive polymeric nanoparticles for treatment of osteoarthritis

Gao

et al. 2020

AMB Expr

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Osteoarthritis (OA) is a condition associated with severe inflammation, cartilage destruction and degeneration of joints. Rhein (Rh) is an effective anti-inflammatory drug with proven efficacy in in-vitro and in-vivo models. pH sensitive Rh and NH 4 HCO 3 laden poly (lactic-co-glycolic acid (PLGA) nanoparticles (NPs) (Rh-PLGA-NPs@NH 4) are developed for an effective treatment of OA. The Rh-PLGA-NPs@NH 4 are prepared along with Rh-PLGA-NPs as a control by double emulsion method. Rh-PLGA-NPs@NH 4 was characterized for their size, shape, morphology and encapsulation efficiency (EE). The effect of pH on release of Rh from Rh-PLGA-NPs@NH 4 was studied at different pH. Further, the cytotoxicity effect of Rh-PLGA-NPs@NH 4 on THP-1 cells were evaluated. Anti-inflammatory efficacy was evaluated on LPS stimulated THP-1 cells and the release of pro-inflammatory cytokines was evaluated and compared with control. The size of Rh-PLGA-NPs@NH 4 and Rh-PLGA-NPs was found to be 190.7 ± 1.2 nm and 134.6 ± 2.4 nm respectively with poly dispersity (PDI) 0.14 and 0.15. The zeta potential of Rh-PLGA-NPs@NH 4 was found to be-22 ± 1.12 mV. Rh-PLGA-NPs@NH 4 were uniform, smooth and spherical shape as confirmed using electron microscopy analysis. Rh-PLGA-NPs@ NH 4 release the Rh more effectively in the low pH of synovial fluid environment (SFE). Rh-PLGA-NPs@NH 4 also significantly affect inflammatory cytokines TNF-α and IL-1β and reduced their release in LPS stimulated THP-1 cells. Reactive oxygen species (ROS), a mediator responsible for the cartilage collapse was also found to be reduced. Results proposes that Rh-PLGA-NPs could provide therapeutic solution to those patients who suffer from chronic joint ailments by reducing the progression of OA.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Rational Design Of Npsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Rhein laden pH-responsive polymeric nanoparticles for treatment of osteoarthritis

Gao

et al. 2020

AMB Expr

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Smart Biomaterials for Articular Cartilage Repair and Regeneration

Wang

et al. 2023

Adv Funct Materials

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Articular cartilage defects bring about disability and worldwide socioeconomic loss, therefore, articular cartilage repair and regeneration is recognized as a global issue. However, due to its avascular and nearly acellular characteristic, cartilage tissue regeneration ability is limited to some extent. Despite the availability of various treatment methods, including palliative drugs and surgical regenerative therapy, articular cartilage repair and regeneration still face major challenges due to the lack of appropriate methods and materials. Smart biomaterials can regulate cell behavior and provide excellent tissue repair and regeneration microenvironment, thus inducing articular cartilage repair and regeneration. This process is adjusted by controlling drug/bioactive factors release via responding to exogenous/endogenous stimuli, tailoring materials’ structure and function similar to native cartilage or providing physiochemical and physical signaling factors. Herein, smart biomaterials, recently applied in articular cartilage repair and regeneration, are elaborated from two aspects: smart drug release system and smart scaffolds. Furthermore, articular cartilage and its defects and advanced manufacturing techniques of smart biomaterials are discussed in brief. Finally, perspectives for smart biomaterials used in articular cartilage repair and regeneration are presented and the clinical translation of smart biomaterials is emphasized.

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Intra‐Articular Injection of Nanomaterials for the Treatment of Osteoarthritis: From Lubrication Function Restoration to Cell and Gene Therapy

Yang,

Zhang

2024

Adv Funct Materials

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Osteoarthritis (OA), a prevalent joint disease affecting many people globally, presents significant challenge in current treatments, which often only manage symptoms without halting disease progression. This review illuminates novel approaches in OA therapy, focusing mainly on intra‐articular injection of nanomaterials. The innovative materials, designed to either mimic or augment natural joint lubrication, show promise in restoring joint biomechanics and alleviating pain. The review delves into an array of biomimetic lubricants, including polymer brush, nanocomposite hydrogel, and nanoparticles, underscoring their roles in anti‐inflammation, targeting, cartilage repair, and drug delivery. Furthermore, the potential of mesenchymal stem cells to differentiate into chondrocytes, coupled with the delivery of these cells and their exosomes via nanomaterials, has promoted cell therapy avenues for OA. The review also highlights the function of non‐coding RNAs such as miRNA, siRNA, circRNA, lncRNA, and antisense oligonucleotides in impeding OA progression, with nanomaterials facilitating their delivery, thus facilitating advanced therapeutic possibilities including immune evasion and bone cell proliferation. Overall, this review encapsulates the evolution of nanomaterials in OA treatment from material to cell, and ultimately to gene therapy, forecasting a future where nanomaterials evolve toward integrated, personalized diagnostics and therapeutics for OA.

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pH-responsive poly(lactide-co-glycolide) nanoparticles containing near-infrared dye for visualization and hyaluronic acid for treatment of osteoarthritis

Abstract: Please cite this article as: L. Zerrillo, I. Que, O. Vepris, et al., pH-responsive poly(lactideco-glycolide) nanoparticles containing near-infrared dye for visualization and hyaluronic acid for treatment of osteoarthritis, Journal of Controlled Release,

Cited by 49 publications

References 46 publications

Rhein laden pH-responsive polymeric nanoparticles for treatment of osteoarthritis

Rhein laden pH-responsive polymeric nanoparticles for treatment of osteoarthritis

Smart Biomaterials for Articular Cartilage Repair and Regeneration

Intra‐Articular Injection of Nanomaterials for the Treatment of Osteoarthritis: From Lubrication Function Restoration to Cell and Gene Therapy

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