pH-responsive polymer in a core–shell magnetic structure as an efficient carrier for delivery of doxorubicin to tumor cells

Zaaeri, Farzaaneh; Khoobi, Mehdi; Rouini, Mohammad-Reza; Javar, Hamid Akbari

doi:10.1080/00914037.2017.1405348

Cited by 35 publications

(26 citation statements)

References 40 publications

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“…A polymer nanocomposite made of polyethyleneimine with a zwitterionic function and paramagnetic iron nanoparticles (nFe 3 O 4 ) was researched as a carrier for DOX delivery. Studies on magnetic targeting and the evaluation of pharmacokinetic and biodistribution data should be initiated to confirm the efficiency of Fe 3 O 4 @ folic acid (FA)-poly(ethylene imine succinate conjugated)-DOX-loaded nanoparticles as a valuable drug carrier [31].…”

Section: Introductionmentioning

confidence: 99%

Polymers and Polymer Nanocomposites for Cancer Therapy

Feldman

2019

Applied Sciences

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Synthetic polymers, biopolymers, and their nanocomposites are being studied, and some of them are already used in different medical areas. Among the synthetic ones that can be mentioned are polyolefins, fluorinated polymers, polyesters, silicones, and others. Biopolymers such as polysaccharides (chitosan, hyaluronic acid, starch, cellulose, alginates) and proteins (silk, fibroin) have also become widely used and investigated for applications in medicine. Besides synthetic polymers and biopolymers, their nanocomposites, which are hybrids formed by a macromolecular matrix and a nanofiller (mineral or organic), have attracted great attention in the last decades in medicine and in other fields due to their outstanding properties. This review covers studies done recently using the polymers, biopolymers, nanocomposites, polymer micelles, nanomicelles, polymer hydrogels, nanogels, polymersomes, and liposomes used in medicine as drugs or drug carriers for cancer therapy and underlines their responses to internal and external stimuli able to make them more active and efficient. They are able to replace conventional cancer drug carriers, with better results. Appl. Sci. 2019, 9, 3899 2 of 24 nanocomposites offer numerous opportunities in diverse applications, including nanocarriers, tissue engineering, antimicrobials, sensors, etc. These new groups of materials have gained significant research interest due to their novel properties, which are gained through the addition of nanofillers. Polymer nanocomposites have significant potential in disease theranostics, and nanotechnology brings great promise in cancer drug carriers [4].Chemotherapy implies the use of drugs and, besides the drugs, carriers. Common products used as carriers include synthetic polymers, biopolymers, and polymer nanocomposites.Some of the most useful drugs for chemotherapy are toxic chemicals able to inhibit the proliferation of cancer cells. The use of chemotherapeutic drugs has been in part hindered by their poor solubility in water, their short biological half-life, their lack of targeting ability, and the development of multidrug resistance [5]. In the last decades, nanoparticles have shown significant promise as an oncology treatment modality. Responsive polymers represent a promising class of nanoparticles that can trigger delivery through the exploitation of a specific stimuli. Response to a stimulus is one of the most basic processes found in living systems. A tutorial review highlighted the recent developments in polymer-based approaches to internally responsive nanoparticles for oncology [6].One important goal of medicine is to develop carriers that can selectively deliver anticancer drugs to tumor cells with no or minimal side effects in healthy cells [7,8].Polymers and their nanocomposites in different forms, such as micelles, hydrogels, polymersomes, and liposomes, have important potential in cancer diagnosis and treatment.Nanocomposites are popular in many areas due to properties such as their unique design capacity, eco-friendly nature, ...

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Section: Introductionmentioning

confidence: 99%

Polymers and Polymer Nanocomposites for Cancer Therapy

Feldman

2019

Applied Sciences

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“…The peak at 1515 cm −1 was attributed to the NH bending and CN stretching complex vibration of the amide group (Amid II). The peaks at 1037 and 897 cm −1 can be attributed to the typical saccharide structure of CHI 33–38 …”

Section: Resultsmentioning

confidence: 97%

Characterization of chitosan/polyethylenimine film layer as a novel anti‐fog coating surface

Türk

2022

J of Applied Polymer Sci

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Anti-fog surfaces have an important place in many areas of daily life. In this study, hybrid coatings of anti-fog chitosan (CHI) and polyethyleneimine (PI) were realized as an innovative film layer. CHI/PI hybrid coatings, produced by the drop-casting method, which is a practical and one-stage deposition process, were coated on the glass and safety glasses substrates. It has been analyzed that the optimum CHI/PI coating is 2:3 (v/v) mixing ratio, which has a contact angle of 4.9 , a hydrodynamic radius of 5.67 nm, and zeta potential of 38.8 mV. It was analyzed that the coating was successfully performed on the surface by FTIR analysis. It was observed that the coating surfaces were obtained as homogeneous and smooth with FESEM and surface profilometer analyzes. Both steam and cold fog tests were carried out to determine the antifogging properties of different surfaces after coating. After the anti-fog tests, the CHI/PI coating had high-transmittance values in the range of 85.9% and 84.6%. After the coatings were exposed to hot-cold environment cycles and subjected to long-term stability testing, the coatings retained their anti-fog properties.

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“…The organic moieties of PEI clearly appear themselves in the region at 2800–3000 cm −1 (C-H stretching) in contrast with pristine CNTs. In addition, a new band at 3401 cm −1 (N-H stretching) appears, and the band at 1382 cm −1 and 1072 cm −1 also correspond to the C-N stretching vibration due to the PEI [ 37 , 38 ]. From the results, it can be confirmed that the amine group was successfully introduced on the surface of the CNT thin film.…”

Section: Resultsmentioning

confidence: 99%

PEI-Functionalized Carbon Nanotube Thin Film Sensor for CO2 Gas Detection at Room Temperature

et al. 2021

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In this study, a polyethyleneimine (PEI)-functionalized carbon nanotube (CNT) sensor was fabricated for carbon dioxide detection at room temperature. Uniform CNT thin films prepared using a filtration method were used as resistive networks. PEI, which contains amino groups, can effectively react with CO2 gas by forming carbamates at room temperatures. The morphology of the sensor was observed, and the properties were analyzed by scanning electron microscope (SEM), Raman spectroscopy, and fourier transform infrared (FT-IR) spectroscopy. When exposed to CO2 gas, the fabricated sensor exhibited better sensitivity than the pristine CNT sensor at room temperature. Both the repeatability and selectivity of the sensor were studied.

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pH-responsive polymer in a core–shell magnetic structure as an efficient carrier for delivery of doxorubicin to tumor cells

Cited by 35 publications

References 40 publications

Polymers and Polymer Nanocomposites for Cancer Therapy

Polymers and Polymer Nanocomposites for Cancer Therapy

Characterization of chitosan/polyethylenimine film layer as a novel anti‐fog coating surface

PEI-Functionalized Carbon Nanotube Thin Film Sensor for CO2 Gas Detection at Room Temperature

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