pH-Responsive PVA/BC-f-GO Dressing Materials for Burn and Chronic Wound Healing with Curcumin Release Kinetics

Abstract

Polymeric materials have been essential biomaterials to develop hydrogels as wound dressings for sustained drug delivery and chronic wound healing. The microenvironment for wound healing is created by biocompatibility, bioactivity, and physicochemical behavior. Moreover, a bacterial infection often causes the healing process. The bacterial cellulose (BC) was functionalized using graphene oxide (GO) by hydrothermal method to have bacterial cellulose-functionalized-Graphene oxide (BC-f-GO). A simple blending method was used to crosslink BC-f-GO with polyvinyl alcohol (PVA) by tetraethyl orthosilicate (TEOS) as a crosslinker. The structural, morphological, wetting, and mechanical tests were conducted using Fourier-transform infrared spectroscopy (FTIR), Scanning electron microscope (SEM), water contact angle, and a Universal testing machine (UTM). The release of Silver-sulphadiazine and drug release kinetics were studied at various pH levels and using different mathematical models (zero-order, first-order, Higuchi, Hixson, Korsmeyer–Peppas, and Baker–Lonsdale). The antibacterial properties were conducted against Gram-positive and Gram-negative severe infection-causing pathogens. These composite hydrogels presented potential anticancer activities against the U87 cell line by an increased GO amount. The result findings show that these composite hydrogels have physical-mechanical and inherent antimicrobial properties and controlled drug release, making them an ideal approach for skin wound healing. As a result, these hydrogels were discovered to be an ideal biomaterial for skin wound healing.

Thermo-Sensitive Poly (N-isopropylacrylamide-co-polyacrylamide) Hydrogel for pH-Responsive Therapeutic Delivery

“…The smart polymer hydrogels are attractive in the biological field, owing to their sharp phase transition under various stimuli, including pH, temperature, light, etc. [ 14 , 15 , 16 , 17 , 18 , 19 ]. Dual-stimuli responsive polymers are more frequently used in various physiological conditions than the mono-stimuli-responsive polymers [ 16 ].…”

Scaffolds in the microbial resistant era: Fabrication, materials, properties and tissue engineering applications

“… P. argenosa, S. aureus, E. faecalis, and E. coli MC3T3-E1 2021 [ 327 ] ARX, CG, and rGO composites cross-linked them with TEOS Cast into glass Petri dishes & dry at 55 ​°C in an oven. S. aureus, E. coli and P. aeruginosa Human red blood cells 2021 [ 328 ] Arabinoxylan-functionalized-GO ​hydrogel with PVA and TEOS Hydrothermal method S. aureus, E. coli and P. aeruginosa MC3T3-E1/Mouse 2022 [ 329 ] Bacterial cellulose-functionalized-GO ​hydrogel with PVA, TEOS and curcumin release Hydrothermal method S. aureus, E. coli and P. aeruginosa Not study/Anticancer against U87 2022 [ 330 ] SA and GO covalently linked and crosslinked with TEOS Solvothermal method E. coli, ​S. aureus ​and ​P.…”

“…ARX, CS and rGO sheets were combined and crosslinked using TEOS as a crosslinker to produce smart pH-sensitive biocompatible composite hydrogels with broad-spectrum antibacterial activity for wound healing [ 327 ]. Multifunctional hydrogels based on ARX-functionalized-GO and bacterial cellulose-functionalized-GO using the hydrothermal method through cross-linking GO-arabinoxylan and PVA with TEOS recently prevented infections ( E. coli , S. aureus , and P. aeruginosa ) and were thus shown to be promising for wound healing [ 329 , 330 ]. Advanced hydrogels based on arabinoxylan-functionalized-GO promoted wound healing in vitro and in vivo [ 329 ].…”

“…Advanced hydrogels based on arabinoxylan-functionalized-GO promoted wound healing in vitro and in vivo [ 329 ]. The advanced hydrogels based on bacterial cellulose-functionalized-GO showed potential anticancer activity against U87 ​cells and could be used for the controlled release of curcumin [ 330 ].…”

Poly(N-vinylpyrrolidone)–Laponite XLG Nanocomposite Hydrogels: Characterization, Properties and Comparison with Divinyl Monomer-Crosslinked Hydrogels

“…Due to their water content and elasticity, which make them resemble human tissue, hydrogels have many uses in the biomedical field, such as tissue engineering, controlled drug delivery, biosensors, wound management, bioprinting, bioadhesives, etc. [ 2 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ]. Hydrogels also display applications in numerous other fields, such as agriculture, catalysis, microfluidics, actuators, cosmetics and hygiene products, membranes, water treatment and so on [ 2 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ].…”