pH-sensitive and mucoadhesive thiolated Eudragit-coated chitosan microspheres

Quan, Ji-Shan; Jiang, Hu‐Lin; Kim, Eun‐Mi; Jeong, Hwan-Jeong; Choi, Yoon-Jaie; Guo, Ding‐Ding; Yoo, Myung-Chul; Lee, Hong-Gu; Cho, Chong‐Su

doi:10.1016/j.ijpharm.2008.04.003

Cited by 47 publications

(26 citation statements)

References 21 publications

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“…These polymers encapsulated, targeted and released antigens in a controlled fashion at the lower region of the intestine [108]. Antigen that can be selectively delivered only to the colon can avoid exposure to the harsh GIT environment and can undergo more efficient transportation across intestinal wall due to the presence of a mild neutral pH, less enzymatic action, low bile salt activity and slow mucosal layer turnover of the colon.…”

Section: Polymeric Npsmentioning

confidence: 99%

Oral delivery of nanoparticle-based vaccines

Marasini

Skwarczynski

Tóth

2014

Expert Review of Vaccines

134

100

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Most infectious diseases are caused by pathogenic infiltrations from the mucosal tract. Therefore, vaccines delivered to the mucosal tissues can mimic natural infections and provide protection at the first site of infection. Thus, mucosal, especially, oral delivery is becoming the most preferred mode of vaccination. However, oral vaccines have to overcome several barriers such as the extremely low pH of the stomach, the presence of proteolytic enzymes and bile salts as well as low permeability in the intestine. Several formulations based on nanoparticle strategies are currently being explored to prepare stable oral vaccine formulations. This review briefly discusses several molecular mechanisms involved in intestinal immune cell activation and various aspects of oral nanoparticle-based vaccine design that should be considered for improved mucosal and systemic immune responses.

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Section: Polymeric Npsmentioning

confidence: 99%

Oral delivery of nanoparticle-based vaccines

Marasini

Skwarczynski

Tóth

2014

Expert Review of Vaccines

134

100

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“…As a result, oral and nasal vaccination has been paid considerable attention as a way to overcome such potential drawbacks and eliminate the problems associated with parenteral administration of vaccines. 4 Better yet, parenteral vaccination mostly stimulates systemic immunity, whereas mucosal vaccination tends to confer both systemic and mucosal immune responses. 5 In regard to mucosal administration of protein drugs or vaccines, microspheres are well known for their controlled delivery formulation, [6][7][8] which would provide a longlasting boosting effect and enhance the effectiveness of the immune response against infectious diseases.…”

Section: Introductionmentioning

confidence: 99%

“…11 Moreover, chitosan possesses mucoadhesivity, beneficial for prolonging the retention time at the mucosal area for a controlled and sustained therapeutic effect. 4 Nontoxicity is another prerequisite property of chitosan, which can be effectively applied for mucosal delivery of vaccines as a form of the microparticulate system. In an aqueous environment, chitosan swells and forms a gellike layer, favorable for the interaction of polymers with glycoprotein in mucous.…”

Section: Introductionmentioning

confidence: 99%

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Design and application of chitosan microspheres as oral and nasal vaccine carriers: an updated review

Islam¹,

Firdous²,

Choi³

et al. 2012

IJN

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Chitosan, a natural biodegradable polymer, is of great interest in biomedical research due to its excellent properties including bioavailability, nontoxicity, high charge density, and mucoadhesivity, which creates immense potential for various pharmaceutical applications. It has gelling properties when it interacts with counterions such as sulfates or polyphosphates and when it crosslinks with glutaraldehyde. This characteristic facilitates its usefulness in the coating or entrapment of biochemicals, drugs, antigenic molecules as a vaccine candidate, and microorganisms. Therefore, chitosan together with the advance of nanotechnology can be effectively applied as a carrier system for vaccine delivery. In fact, chitosan microspheres have been studied as a promising carrier system for mucosal vaccination, especially via the oral and nasal route to induce enhanced immune responses. Moreover, the thiolated form of chitosan is of considerable interest due to its improved mucoadhesivity, permeability, stability, and controlled/extended release profile. This review describes the various methods used to design and synthesize chitosan microspheres and recent updates on their potential applications for oral and nasal delivery of vaccines. The potential use of thiolated chitosan microspheres as next-generation mucosal vaccine carriers is also discussed.

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“…The electrophoresis was done at a constant voltage of 150 V. Protein bands on the gel were stained with GELCODE_ Blue Stain Reagent[124].…”

mentioning

confidence: 99%