PH-sensitive bionanocomposite hydrogel beads based on carboxymethyl cellulose/ZnO nanoparticle as drug carrier

Zare‐Akbari, Zhila; Farhadnejad, Hassan; Furughi-Nia, Behrouz; Abedin, Saeedeh; Yadollahi, Mehdi; Khorsand-Ghayeni, Mohammad

doi:10.1016/j.ijbiomac.2016.09.110

Cited by 155 publications

(50 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CHI/AA hydrogel sponges have no sharp diffraction peaks except a broadband in the range of 2θ = 18°–25° which imply the amorphous nature of the hydrogel structure. In addition, CHI/AA/ZnO‐3 nanostructured hydrogel sponges showed three additional peaks at 2θ values of 33°, 38°, and 45° which were related to the ZnO crystallite . These characteristic peaks in the XRD pattern of CHI/AA/ZnO‐3 nanostructured hydrogel sponge indicated that ZnO particles were successfully loaded into CHI/AA sponge, supporting the SEM–EDS results.…”

Section: Resultssupporting

confidence: 74%

“…According to the FTIR spectra of hydrogels incorporating ZnO nanoparticles, the broadening peaks around 3450 cm −1 attributed to the intermolecular hydrogen bonding between the ZnO nanoparticles and chitosan . In addition, the absorption peak observed at the range of 500–580 cm −1 are ascribed to the vibration of O‐Zn‐O groups, which confirming the presence of ZnO nanoparticles in the polymer matrix due to the hydrogen bonds between ZnO and CHI …”

Section: Resultsmentioning

confidence: 88%

“…As it is obvious, there is a significant decrease in the drug release from the CHI/AA‐ZnO‐1 hydrogel sponges. Because the releasing time of drug from nanostructured hydrogel sponges is prolonged due to a longer path required for DEX to move from the CHI/AA‐ZnO‐1 hydrogel sponges to the release medium compared with the neat hydrogel sponges . On the other hand, DEX release rate exhibited a tendency to increase while ZnO amount increased in the hydrogel network.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Sponge‐like chitosan‐based nanostructured antibacterial material as a topical hemostat

Bal‐Öztürk

Karal-Yılmaz

Akgüner

et al. 2019

J of Applied Polymer Sci

View full text Add to dashboard Cite

In this study, chitosan/alginic acid/zinc oxide (CHI/AA/ZnO) nanostructured hydrogel sponges were fabricated by incorporating ZnO nanoparticles (<100 nm) into polymer matrix to develop a new potential biomaterial for hemorrhage control. For this purpose, the crosslinked CHI/AA/ZnO nanostructured sponges were synthesized by freeze‐drying technique. Genipin was used as a crosslinker. The prepared chitosan‐based sponges were characterized by Fourier transform infrared spectroscopy, X‐ray diffraction, and scanning electron microscopy—energy‐dispersive spectroscopy analysis. The effects of ZnO content on the physicochemical characteristics of sponge‐like nanostructured hydrogels were evaluated by swelling ratio in two different pH values. Physical immobilization of dexamethasone as a model drug in hydrogel matrix resulted sustained release of drug more than 3 days. Antibacterial activity of hydrogel sponges was assessed against Staphylococcus aureus. The cytotoxicity and hemostatic efficacy of crosslinked CHI/AA/ZnO sponge like‐nanostructured hydrogels was evaluated in vitro and in vivo, respectively. The results of this study demonstrated that the prepared CHI/AA/ZnO nanostructured sponge had the potential to be an antibacterial topical hemostat. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47522.

show abstract

Section: Resultssupporting

confidence: 74%

Section: Resultsmentioning

confidence: 88%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Sponge‐like chitosan‐based nanostructured antibacterial material as a topical hemostat

Bal‐Öztürk

Karal-Yılmaz

Akgüner

et al. 2019

J of Applied Polymer Sci

View full text Add to dashboard Cite

show abstract

“…103 Moreover, the ZnO hydrogels showed great potential in drug carrying and wound healing in some recent studies. [103][104][105] CMC and CS hydrogels were also reported to be used as a hydrogel matrix for ZnO NPs. 98,99,106 CMC hydrogels exhibited antibacterial activity against both Gram-positive and Gram-negative bacteria, and CS hydrogels were confirmed eligible wound dressing materials.…”

Section: Zinc Oxide Nanoparticles (Zno Nps)mentioning

confidence: 99%

Antimicrobial hydrogels: promising materials for medical application

Yang

Han

Chen

et al. 2018

IJN

321

230

View full text Add to dashboard Cite

The rapid emergence of antibiotic resistance in pathogenic microbes is becoming an imminent global public health problem. Local application of antibiotics might be a solution. In local application, materials need to act as the drug delivery system. The drug delivery system should be biodegradable and prolonged antibacterial effect should be provided to satisfy clinical demand. Hydrogel is a promising material for local antibacterial application. Hydrogel refers to a kind of biomaterial synthesized by a water-soluble natural polymer or a synthesized polymer, which turns into gel according to the change in different signals such as temperature, ionic strength, pH, ultraviolet exposure etc. Because of its high hydrophilicity, unique three-dimensional network, fine biocompatibility and cell adhesion, hydrogel is one of the suitable biomaterials for drug delivery in antimicrobial areas. In this review, studies from the past 5 years were reviewed, and several types of antimicrobial hydrogels according to different ingredients, different preparations, different antimicrobial mechanisms, different antimicrobial agents they contained and different applications, were summarized. The hydrogels loaded with metal nanoparticles as a potential method to solve antibiotic resistance were highlighted. Finally, future prospects of development and application of antimicrobial hydrogels are suggested.

show abstract

“…Researchers have focused on identifying materials that are non-toxic, environmentally friendly, and highly biocompatible. In previous studies, natural materials, such as polysaccharides, have been employed as reinforcement materials during the production of hydrogels [14], [15], [16], [17], [18]. Bacterial cellulose is considered to be one of the most effective reinforcement materials.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of bacterial cellulose and gelatin-based hydrogel composites for drug-delivery systems

Treesuppharat

Rojanapanthu

Siangsanoh

et al. 2017

Biotechnology Reports

232

View full text Add to dashboard Cite

show abstract

PH-sensitive bionanocomposite hydrogel beads based on carboxymethyl cellulose/ZnO nanoparticle as drug carrier

Cited by 155 publications

References 42 publications

Sponge‐like chitosan‐based nanostructured antibacterial material as a topical hemostat

Sponge‐like chitosan‐based nanostructured antibacterial material as a topical hemostat

Antimicrobial hydrogels: promising materials for medical application

Synthesis and characterization of bacterial cellulose and gelatin-based hydrogel composites for drug-delivery systems

Contact Info

Product

Resources

About