pH-sensitive charge-conversional and NIR responsive bubble-generating liposomal system for synergetic thermo-chemotherapy

Chen, Ming-Mao; Song, Feifei; Feng, Mengyu; Liu, Yan; Liu, Yuan-Yuan; Tian, Jia; Lv, Feng; Zhang, Qiqing

doi:10.1016/j.colsurfb.2018.04.001

Cited by 23 publications

(10 citation statements)

References 38 publications

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“…(According to the Ref. [ 63 – 73 ]. PDMAEMA poly(2-dimethylaminoethyl methacrylate), PBAE poly(beta-amino ester), PDEAEMA poly(2‐(diethylamino)ethyl methacrylate), P4VP poly(4-vinylpyridine), PHis poly(histidine), PSD poly(methacryloyl sulfadimethoxine), PMAA poly(methacrylic acid), PAsp poly(aspartic acid) …”

Section: Mechanisms Of Triggered Surface Charge Conversionmentioning

confidence: 99%

“…Shielding/deshielding strategy can be used in different NDDSs, such as liposomes. Chen et al prepared a charge-conversional liposomal system to enhance cancer therapeutic efficacy [ 73 ]. The cationic liposomes containing Cypate, DOX and NH 4 HCO 3 were shielded by pH-sensitive poly(methacryloyl sulfadimethoxine) (PSD) through electrostatic interaction at pH 7.4.…”

Section: Mechanisms Of Triggered Surface Charge Conversionmentioning

confidence: 99%

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Charge reversal nano-systems for tumor therapy

Zhang

Chen

et al. 2022

J Nanobiotechnol

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Surface charge of biological and medical nanocarriers has been demonstrated to play an important role in cellular uptake. Owing to the unique physicochemical properties, charge-reversal delivery strategy has rapidly developed as a promising approach for drug delivery application, especially for cancer treatment. Charge-reversal nanocarriers are neutral/negatively charged at physiological conditions while could be triggered to positively charged by specific stimuli (i.e., pH, redox, ROS, enzyme, light or temperature) to achieve the prolonged blood circulation and enhanced tumor cellular uptake, thus to potentiate the antitumor effects of delivered therapeutic agents. In this review, we comprehensively summarized the recent advances of charge-reversal nanocarriers, including: (i) the effect of surface charge on cellular uptake; (ii) charge-conversion mechanisms responding to several specific stimuli; (iii) relation between the chemical structure and charge reversal activity; and (iv) polymeric materials that are commonly applied in the charge-reversal delivery systems. Graphical Abstract

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Section: Mechanisms Of Triggered Surface Charge Conversionmentioning

confidence: 99%

Section: Mechanisms Of Triggered Surface Charge Conversionmentioning

confidence: 99%

Charge reversal nano-systems for tumor therapy

Zhang

Chen

et al. 2022

J Nanobiotechnol

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“…However, they are rapidly cleared from blood circulation due to interactions with anionic biomacromolecules, such as serum components. Chen et al [121] developed cationic LPs containing Cypate, DOX and NH4HCO3, and shielded by a pH-responsive polymer (PSD, 51, Fig. 12), negatively charged in blood.…”

Section: Ph-sensitive Polymers and Copolymersmentioning

confidence: 99%

Stimulus-responsive liposomes for biomedical applications

Antoniou

Giofrè

Seneci

et al. 2021

Drug Discovery Today

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Liposomes are amphipathic lipidic supramolecular aggregates able to encapsulate and carry molecules of both hydrophilic and hydrophobic nature. They have been widely used as in vivo drug delivery systems since long due to their favorable features, such as synthetic flexibility, biodegradability, biocompatibility, low immunogenicity, and negligible toxicity. In recent years, the possibility to introduce chemical modifications on liposomes has paved the way to smart liposome-based drug delivery systems characterized by even more tunable and disease-directed features. In this review, the different types of chemical modifications introduced so far have been highlighted, with a particular focus on internal stimuli-responsive liposomes and pro-drug activation.

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“…(A) Zwitterionic liposomes reverse their charge from cationic to anionic when suspension pH increases from below to above the Iso-Electric Point (IEP) of the constituting lipids or vice versa. (B) Charge reversal of poly(methacryloyl sulfadimethoxine) (PSD) liposomes(Chen et al, 2018) (with permission of Elsevier).…”

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confidence: 99%

Lipid-Based Antimicrobial Delivery-Systems for the Treatment of Bacterial Infections

et al. 2020

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Many nanotechnology-based antimicrobials and antimicrobial-delivery-systems have been developed over the past decades with the aim to provide alternatives to antibiotic treatment of infectious-biofilms across the human body. Antimicrobials can be loaded into nanocarriers to protect them against de-activation, and to reduce their toxicity and potential, harmful side-effects. Moreover, antimicrobial nanocarriers such as micelles, can be equipped with stealth and pH-responsive features that allow self-targeting and accumulation in infectious-biofilms at high concentrations. Micellar and liposomal nanocarriers differ in hydrophilicity of their outer-surface and inner-core. Micelles are self-assembled, spherical core-shell structures composed of single layers of surfactants, with hydrophilic head-groups and hydrophobic tail-groups pointing to the micellar core. Liposomes are composed of lipids, self-assembled into bilayers. The hydrophilic head of the lipids determines the surface properties of liposomes, while the hydrophobic tail, internal to the bilayer, determines the fluidity of liposomal-membranes. Therefore, whereas micelles can only be loaded with hydrophobic antimicrobials, hydrophilic antimicrobials can be encapsulated in the hydrophilic, aqueous core of liposomes and hydrophobic or amphiphilic antimicrobials can be inserted in the phospholipid bilayer. Nanotechnology-derived liposomes can be prepared with diameters <100-200 nm, required to prevent reticulo-endothelial rejection and allow penetration into infectious-biofilms. However, surface-functionalization of liposomes is considerably more difficult than of micelles, which explains while self-targeting, pH-responsive liposomes that find their way through the blood circulation toward infectious-biofilms are still challenging to prepare. Equally, development of liposomes that penetrate over the entire thickness of biofilms to provide deep killing of biofilm inhabitants still provides a challenge. The liposomal phospholipid bilayer easily fuses with bacterial cell membranes to release high antimicrobial-doses directly inside bacteria. Arguably, protection against de-activation of antibiotics in liposomal nanocarriers and their fusogenicity constitute the biggest advantage of liposomal antimicrobial carriers over antimicrobials free in solution. Many Gram-negative and Gram-positive bacterial strains, resistant to specific antibiotics, Wang et al. Lipid-Based Antimicrobial Delivery-Systems have been demonstrated to be susceptible to these antibiotics when encapsulated in liposomal nanocarriers. Recently, also progress has been made concerning large-scale production and long-term storage of liposomes. Therewith, the remaining challenges to develop self-targeting liposomes that penetrate, accumulate and kill deeply in infectious-biofilms remain worthwhile to pursue.

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pH-sensitive charge-conversional and NIR responsive bubble-generating liposomal system for synergetic thermo-chemotherapy

Cited by 23 publications

References 38 publications

Charge reversal nano-systems for tumor therapy

Charge reversal nano-systems for tumor therapy

Stimulus-responsive liposomes for biomedical applications

Lipid-Based Antimicrobial Delivery-Systems for the Treatment of Bacterial Infections

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