pH-sensitive drug delivery based on chitosan wrapped graphene quantum dots with enhanced fluorescent stability

Sheng, Yanshan; Dai, Wenyu; Gao, Jun; Li, Hongda; Tan, Wensheng; Wang, Jingwei; Deng, Linhong; Kong, Yong

doi:10.1016/j.msec.2020.110888

Cited by 52 publications

(28 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hence, the particles demonstrated an excellent pH-triggered drug release performance. Sheng et al [142] prepared graphene quantum dots (GQDs) by the pyrolysis of citric acid (CA). They used them for the loading of hydrophilic cytarabine (Cyt), an anti-cancer drug, and then wrapped them with CS gels for the encapsulation of the loaded Cyt.…”

Section: Carbon Quantum Dots (Cqds)mentioning

confidence: 99%

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Mikušová

Mikuš

2021

IJMS

295

120

View full text Add to dashboard Cite

Nanoparticles (NPs) have an outstanding position in pharmaceutical, biological, and medical disciplines. Polymeric NPs based on chitosan (CS) can act as excellent drug carriers because of some intrinsic beneficial properties including biocompatibility, biodegradability, non-toxicity, bioactivity, easy preparation, and targeting specificity. Drug transport and release from CS-based particulate systems depend on the extent of cross-linking, morphology, size, and density of the particulate system, as well as physicochemical properties of the drug. All these aspects have to be considered when developing new CS-based NPs as potential drug delivery systems. This comprehensive review is summarizing and discussing recent advances in CS-based NPs being developed and examined for drug delivery. From this point of view, an enhancement of CS properties by its modification is presented. An enhancement in drug delivery by CS NPs is discussed in detail focusing on (i) a brief summarization of basic characteristics of CS NPs, (ii) a categorization of preparation procedures used for CS NPs involving also recent improvements in production schemes of conventional as well as novel CS NPs, (iii) a categorization and evaluation of CS-based-nanocomposites involving their production schemes with organic polymers and inorganic material, and (iv) very recent implementations of CS NPs and nanocomposites in drug delivery.

show abstract

Section: Carbon Quantum Dots (Cqds)mentioning

confidence: 99%

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Mikušová

Mikuš

2021

IJMS

295

120

View full text Add to dashboard Cite

show abstract

“…GQDs loaded with cytarabine ( Figure 4 ) and wrapped with chitosan (CS) gels to achieve the encapsulation of the loaded drug were characterized with improved fluorescent stability due to suppressed agglomeration of GQDs by the CS gels. The pH-sensitive release of cytarabine from this nanocarrier related to the hydrolysis of the amide linkage between GQDs and the drug in acidic medium [ 132 ]. GQD-modified poly( N , N -diethyl acrylamide) nanohydrogel with particle sizes 68.1–87.5 nm encapsulating DOX showed a considerably ameliorated drug release at temperatures of release media close to physiological temperatures.…”

Section: Graphene Quantum Dotsmentioning

confidence: 99%

Advances in Drug Delivery Nanosystems Using Graphene-Based Materials and Carbon Nanotubes

2021

View full text Add to dashboard Cite

Carbon is one of the most abundant elements on Earth. In addition to the well-known crystallographic modifications such as graphite and diamond, other allotropic carbon modifications such as graphene-based nanomaterials and carbon nanotubes have recently come to the fore. These carbon nanomaterials can be designed to help deliver or target drugs more efficiently and to innovate therapeutic approaches, especially for cancer treatment, but also for the development of new diagnostic agents for malignancies and are expected to help combine molecular imaging for diagnosis with therapies. This paper summarizes the latest designed drug delivery nanosystems based on graphene, graphene quantum dots, graphene oxide, reduced graphene oxide and carbon nanotubes, mainly for anticancer therapy.

show abstract

“…Finally, Sheng et al developed GQDs functionalized with chitosan gels (CS) for loading hydrophilic cytarabine (Cyt), an anticancer drug [ 219 ]. The release of Cyt from the designed carrier was sensitive to acidic pH.…”

Section: Reviewmentioning

confidence: 99%

Graphene and its derivatives: understanding the main chemical and medicinal chemistry roles for biomedical applications

et al. 2021

View full text Add to dashboard Cite

Graphic abstract Over the past few years, there has been a growing potential use of graphene and its derivatives in several biomedical areas, such as drug delivery systems, biosensors, and imaging systems, especially for having excellent optical, electronic, thermal, and mechanical properties. Therefore, nanomaterials in the graphene family have shown promising results in several areas of science. The different physicochemical properties of graphene and its derivatives guide its biocompatibility and toxicity. Hence, further studies to explain the interactions of these nanomaterials with biological systems are fundamental. This review has shown the applicability of the graphene family in several biomedical modalities, with particular attention for cancer therapy and diagnosis, as a potent theranostic. This ability is derivative from the considerable number of forms that the graphene family can assume. The graphene-based materials biodistribution profile, clearance, toxicity, and cytotoxicity, interacting with biological systems, are discussed here, focusing on its synthesis methodology, physicochemical properties, and production quality. Despite the growing increase in the bioavailability and toxicity studies of graphene and its derivatives, there is still much to be unveiled to develop safe and effective formulations.

show abstract

pH-sensitive drug delivery based on chitosan wrapped graphene quantum dots with enhanced fluorescent stability

Cited by 52 publications

References 33 publications

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Advances in Drug Delivery Nanosystems Using Graphene-Based Materials and Carbon Nanotubes

Graphene and its derivatives: understanding the main chemical and medicinal chemistry roles for biomedical applications

Contact Info

Product

Resources

About