pH-Sensitive hydrogels of dextran: Synthesis, characterization and<i>in vivo</i>studies

Giannuzzo, Maria; Corrente, Federica; Feeney, Michelle; Paoletti, L.; Paolicelli, Patrizia; Tita, B.; Vitali, Federica; Casadei, Maria Antonietta

doi:10.1080/10611860802201191

Cited by 14 publications

(7 citation statements)

References 14 publications

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“…The release profiles agree with the swelling data previously obtained for the same hydrogel. Similar observations have been made by Giannuzzo et al where they have observed relatively quicker release in pH 7.4 buffer than in 0.1 mol L −1 HCl . The Dext–pMeAc hydrogels prepared in this study can be used as drug carriers in the pharmaceutical industry due to their ability to protect drugs from the harmful gastric environment.…”

Section: Resultssupporting

confidence: 89%

Heterogeneous and homogeneous structure dextran–poly(methacrylic acid) interpenetrating network hydrogels: synthesis and an application study

Ekici¹

2012

Polymer International

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pH‐sensitive dextran–poly(methacrylic acid) (Dext–pMeAc) full interpenetrating network hydrogels (INHs) were prepared by simultaneous radical polymerization of methacrylic acid monomer (MeAc) and Dext polymer chains in the presence of N,N‐methylenebisacrylamide (MBA) as crosslinker in aqueous solution. These hydrogels were investigated as a drug carrier. The influence of MeAc and MBA contents in the network hydrogels on the swelling behaviour and mechanical strength of prepared Dext–pMeAc INHs was evaluated. Dext–pMeAc INHs were characterized by Fourier transform IR spectroscopy, and kinetic swelling measurements were carried out in deionized water and in simulated gastric fluids (pH 1.1 and pH 7.4). Dext–pMeAc/1‐1, Dext–pMeAc/3‐1 and Dext–pMeAc/5‐1 hydrogels with molar ratios of nDext/nMeAc = 10 and nMBA/nDext = 10, 30 and 50 respectively showed a core–shell structure when they swelled. This phenomenon was not observed in Dext–pMeAc/5‐2, Dext–pMeAc/5‐3 and Dext–pMeAc/5‐5 hydrogels containing a higher amount of Dext in the gels. The swelling data proved the formation of INHs with pH‐sensitive behaviour. A drug release study was performed using Rhodamine 6G fluorescent dye as a model hydrophilic bioactive molecule. The in vitro release rate of Rhodamine 6G from Dext–pMeAc/5‐3 hydrogel was dependent on the pH of the release medium. Copyright © 2012 Society of Chemical Industry

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Section: Resultssupporting

confidence: 89%

Heterogeneous and homogeneous structure dextran–poly(methacrylic acid) interpenetrating network hydrogels: synthesis and an application study

Ekici¹

2012

Polymer International

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“…Photochemical crosslinking significantly improved the swelling properties of hydrogels made of collagen, 4,59 alginate, 68 and dextran. 70 Surface modification for improvement of biocompatibility: Surface modification of biomaterial surface via photochemical reactions has been used for many years. [71][72][73] One important surface property improved by photochemical modification is the hematocompatibility of thrombogenic materials such as titanium, polyurethane, and collagen.…”

Section: Chanmentioning

confidence: 99%

Biomedical Applications of Photochemistry

Chan

2010

Tissue Engineering Part B: Reviews

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Photochemistry is the study of photochemical reactions between light and molecules. Recently, there have been increasing interests in using photochemical reactions in the fields of biomaterials and tissue engineering. This work revisits the components and mechanisms of photochemistry and reviews biomedical applications of photochemistry in various disciplines, including oncology, molecular biology, and biosurgery, with particular emphasis on tissue engineering. Finally, potential toxicities and research opportunities in this field are discussed.

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“…[74]. saccharides have been investigated for the preparation of hydrogels suitable as delivery systems, including chitosan [22,92], alginate [93], dextran [94], guar gum [95], hyaluronic acid [96]. Moreover, derivatizations of these polysaccharides further promoted their properties and therefore increased possible application.…”

Section: Current and Future Developmentsmentioning

confidence: 99%

Intelligent Hydrogels for Drug Delivery System

Zuo²,

Xie³

et al. 2011

DDF

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Intelligent hydrogel, also known as smart hydrogels, are materials with great potential for development in drug delivery system. Intelligent hydrogel also has the ability to perceive as a signal structure change and stimulation. The review introduces the temperature-, pH-, electric signal-, biochemical molecule-, light- and pressure- sensitive hydrogels. Finally, we described the application of intelligent hydrogel in drug delivery system and the recent patents involved for hydrogel in drug delivery.

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pH-Sensitive hydrogels of dextran: Synthesis, characterization andin vivostudies

Cited by 14 publications

References 14 publications

Heterogeneous and homogeneous structure dextran–poly(methacrylic acid) interpenetrating network hydrogels: synthesis and an application study

Heterogeneous and homogeneous structure dextran–poly(methacrylic acid) interpenetrating network hydrogels: synthesis and an application study

Biomedical Applications of Photochemistry

Intelligent Hydrogels for Drug Delivery System

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