pH-sensitive micelles self-assembled from multi-arm star triblock co-polymers poly(ε-caprolactone)-b-poly(2-(diethylamino)ethyl methacrylate)-b-poly(poly(ethylene glycol) methyl ether methacrylate) for controlled anticancer drug delivery

Folate-decorated hydrophilic three-arm star-block terpolymer as a novel nanovehicle for targeted co-delivery of doxorubicin and Bcl-2 siRNA in breast cancer therapy

“…Recently, amphiphilic cationic star-block copolymers have been actively investigated in the field of drug and gene delivery [28]. Undoubtedly, these copolymers can self-assemble into more stable nanoparticles with similar topological structures to those assembled from the corresponding linear block analogues [29].…”

Structure–property relationship of pH‐sensitive (PCL)2(PDEA‐b‐PPEGMA)2 micelles: Experiment and DPD simulation

“…An ideal anticancer pH-sensitive micelle can remain stable in normal tissues (pH 7.4) while release drugs rapidly in tumoral conditions (pH 5.0). [5][6][7][8] Although pH-sensitive micelles have been extensively investigated, it is still highly demanded to make a deeper understanding of structural transformation and drug release mechanism at varying pH conditions.…”

Poly(2-(diethylamino)ethyl methacrylate)-based, pH-responsive, copolymeric mixed micelles for targeting anticancer drug control release

“…The dried micelles were stored at −20°C until further experiments. The method to determine the drug-loading content (LC) and entrapment efficiency (EE) was reported in our previous works, 17,18 and the detail procedure is shown in the Supplementary materials.…”

“…[15][16][17][18] In particular, pH-responsive polymeric micelles are selfassembled by triblock or multi-block copolymers containing hydrophilic blocks, hydrophobic blocks and functional response blocks. A substantial proportion of hydrophilic/ hydrophobic block in the micelles structure improved the in vivo micelle stability and drug-loading capability but at the price of the reduced micellar pH responsiveness.…”

“…17,18,[40][41][42][43] Equation 1 was used to fit the drug release profiles, with n indicating the drug release mechanism and k reflecting the rate constant of the DOX release. The release process of the three DOX-loaded micelles can be divided into two stages, with the first stage from 0 to 12 h and the second stage between 12 and 96 h. The linear fitting curves of micelle I, mixed micelle II and mixed micelle III are shown in Figure 8A-C, respectively, and the fitting parameters are listed in Table 3.…”