pH-sensitive particles of polymer-surfactant complexes based on a copolymer of N,N′-diallyl-N,N′-dimethylammonium chloride with maleic acid and sodium dodecyl sulfate

Бабаев, М. С.; Лобов, А. Н.; Шишлов, Н. М.; Kolesov, S. V.

doi:10.1016/j.reactfunctpolym.2022.105359

Cited by 5 publications

(3 citation statements)

References 89 publications

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“…The presence of a higher number of carboxyl groups in the polymer results in increased acidity, requiring a greater quantity of NaOH solution to raise the pH level, as shown in Figure 5C . This technique has been widely used to determine the quantification of carboxyl groups in materials, considering the material’s acidity ( El Jundi et al, 2020 ; El Jundi et al, 2020 ; Babaev et al, 2022 ; Babaev et al, 2022 ). Therefore, the results of the titration curve provide additional evidence of the successful carboxylation of PEUU.…”

Section: Resultsmentioning

confidence: 99%

Polyester urethane urea (PEUU) functionalization for enhanced anti-thrombotic performance: advancing regenerative cardiovascular devices through innovative surface modifications

Rodríguez-Soto,

Suárez Vargas,

Ayala-Velásquez

et al. 2023

Front. Bioeng. Biotechnol.

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Introduction: Thrombogenesis, a major cause of implantable cardiovascular device failure, can be addressed through the use of biodegradable polymers modified with anticoagulating moieties. This study introduces a novel polyester urethane urea (PEUU) functionalized with various anti-platelet deposition molecules for enhanced antiplatelet performance in regenerative cardiovascular devices.Methods: PEUU, synthesized from poly-caprolactone, 1,4-diisocyanatobutane, and putrescine, was chemically oxidized to introduce carboxyl groups, creating PEUU-COOH. This polymer was functionalized in situ with polyethyleneimine, 4-arm polyethylene glycol, seleno-L-cystine, heparin sodium, and fondaparinux. Functionalization was confirmed using Fourier-transformed infrared spectroscopy and X-ray photoelectron spectroscopy. Bio-compatibility and hemocompatibility were validated through metabolic activity and hemolysis assays. The anti-thrombotic activity was assessed using platelet aggregation, lactate dehydrogenase activation assays, and scanning electron microscopy surface imaging. The whole-blood clotting time quantification assay was employed to evaluate anticoagulation properties.Results: Results demonstrated high biocompatibility and hemocompatibility, with the most potent anti-thrombotic activity observed on pegylated surfaces. However, seleno-L-cystine and fondaparinux exhibited no anti-platelet activity.Discussion: The findings highlight the importance of balancing various factors and addressing challenges associated with different approaches when developing innovative surface modifications for cardiovascular devices.

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Section: Resultsmentioning

confidence: 99%

Polyester urethane urea (PEUU) functionalization for enhanced anti-thrombotic performance: advancing regenerative cardiovascular devices through innovative surface modifications

Rodríguez-Soto,

Suárez Vargas,

Ayala-Velásquez

et al. 2023

Front. Bioeng. Biotechnol.

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“…In recent work, periodically structured copolymers based on DADMAC and maleic acid (MA) (ratio of units DADMAC/MA = 2:1) have been employed for forming PESCs with SDS, and depending on the composition and degree of neutralization of the MA particle, radii of 90–250 nm were observed. These PESCs were then shown to be able to well-solubilize the dye Oil Yellow OB, where the solubility enhancement had only a minor dependence on the PESC size …”

Section: Polyelectrolyte–surfactant Complexesphase Behavior Structur...mentioning

confidence: 99%

“…These PESCs were then shown to be able to well-solubilize the dye Oil Yellow OB, where the solubility enhancement had only a minor dependence on the PESC size. 60…”

Section: Structure Of Pescsmentioning

confidence: 99%

Polyelectrolyte–Surfactant Complexes As a Formulation Tool for Drug Delivery

Gradzielski

2022

Langmuir

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Aqueous polyelectrolyte−surfactant complexes (PESCs) are very rich with respect to their properties and the structures formed by them. By design they normally contain hydrophobic micellar surfactant aggregates complexed by long polyelectrolyte chains, thereby combining the formation of small hydrophobic domains given by the surfactant with large-scale structuring due to the presence of the polyelectrolyte chain. In addition, they contain highly polar regions of surfactant head groups in contact with polyelectrolyte, forming a shell around the micellar aggregates, which often also possesses a certain hydrophobic character. Accordingly, the ability for solubilization of waterinsoluble compounds of different sorts is particularly versatile in PESCs. Their solubilization sites with very different polarities and hydrophobic characters make them very flexible in adapting to the requirements of a given drug molecule. This renders them attractive for potential applications in drug delivery. In addition, modification of the rheological properties via self-assembly and network formation can be very important in PESC applications. In the following, we discuss the structures of PESCs and their properties, with a focus on the solubilization properties. Subsequently, examples are described where PESCs have been employed in the context of drug solubilization and delivery. These comprise examples with individual aggregates, cross-linked hydrogels, and ones taking advantage of the high solubilization capacity of microemulsions.

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Self-Organizing Particles of Polymer–Colloid Complexes Based on Various Molecular Weight Copolymers of N,N'-Diallyl-N,N'-dimethylammonium Chloride with Sulfur Dioxide

Бабаев

Колесов

2023

Polym. Sci. Ser. B

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pH-sensitive particles of polymer-surfactant complexes based on a copolymer of N,N′-diallyl-N,N′-dimethylammonium chloride with maleic acid and sodium dodecyl sulfate

Cited by 5 publications

References 89 publications

Polyester urethane urea (PEUU) functionalization for enhanced anti-thrombotic performance: advancing regenerative cardiovascular devices through innovative surface modifications

Polyester urethane urea (PEUU) functionalization for enhanced anti-thrombotic performance: advancing regenerative cardiovascular devices through innovative surface modifications

Polyelectrolyte–Surfactant Complexes As a Formulation Tool for Drug Delivery

Self-Organizing Particles of Polymer–Colloid Complexes Based on Various Molecular Weight Copolymers of N,N'-Diallyl-N,N'-dimethylammonium Chloride with Sulfur Dioxide

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