pH sensitive polyelectrolyte complex of O-carboxymethyl chitosan and poly (acrylic acid) cross-linked with calcium for sustained delivery of acid susceptible drugs

The design of pH-sensitive chitosan-based formulations for gastrointestinal delivery

“…BSA was loaded into the complexes and the in vitro drug release study showed the beads swelled slightly at pH 1.2 and the release of BSA is less than 18%, whereas they swelled significantly at pH 7.4 and almost all BSA was released within 3 hours. Besides, carboxymethyl-chitosan-soy-protein complex [39] and O-carboxymethyl-chitosan-carbopol complex [39] were also developed via the Ca 2+ -induced gelation approach for intestinal delivery.…”

Chitosan/o-carboxymethyl chitosan nanoparticles for efficient and safe oral anticancer drug delivery: In vitro and in vivo evaluation

“…O-carboxymethyl chitosan (CMCS) is a water soluble chitosan derivative and the carboxyl group on CMCS make it obtain high capacity to bind Ca 2+ (Feng et al, 2011;Gujarathi et al, 2012). This property could deprive the divalent ions from extracellular matrix and increase the parallular permeability of the epithelium Please cite this article in press as: Feng (Bromberg and Alakhov, 2003).…”

Bifunctional Magnetic-Fluorescent Nanoparticles: Synthesis, Characterization, and Cell Imaging

“…29 Then, PDI-PtBA was synthesized via ATRP ( Figure S1) and the removal of the tert-butyl protective groups was achieved under acidic conditions to yield the target polymer PDI-PAA ( Figure S2). The detailed descriptions can be found in the experimental sections.…”

“…First, PDI-4Br was synthesized as the ATRP initiator according to the reference. [27][28][29] Then the Fe3O4@SiO2-PDI-PAA/Ca 2+ NPs with good magnetic and fluorescent properties were designed and prepared. The repeat units of each arm in PDI-PAA were well controlled to about 50, determined by 1 H NMR and GPC (Table S1).…”

“…[27][28][29] The stability, cytotoxicity, and cellular uptake of such NPs were investigated for potential biomedical applications, such as drug delivery and magnetic imaging. The PDI-cored star polymer (PDI-PAA) was prepared through atom transfer radical polymerization (ATRP) strategy.…”