2024
DOI: 10.1021/acs.chemmater.4c01700
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pH-Sensitive Polymer–Drug Conjugates

Elizabeth R. Gillies

Abstract: Polymer−drug conjugates (PDCs) were introduced with the goal of improving the properties of drug molecules, such as their solubility, blood circulation time, and tissue targeting. Since the first examples dating back decades, substantial progress has been made in the design and implementation of linkages that enable the selective release of drugs in response to physiological stimuli associated with various pathologies. Among these stimuli, a change in pH from neutral to mildly acidic has been one of the most w… Show more

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