pH-sensitive polymer-liposome-based antigen delivery systems potentiated with interferon-γ gene lipoplex for efficient cancer immunotherapy

Yuba, Eiji; Kanda, Yuhei; Yoshizaki, Yuta; Teranishi, Ryoma; Harada, Atsushi; Sugiura, Kikuya; Izawa, Takeshi; Yamate, Jyoji; Sakaguchi, Naoki; Koiwai, Kazunori; Kono, Kenji

doi:10.1016/j.biomaterials.2015.07.031

Cited by 83 publications

(55 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to their positive surface charges, cationic liposomes readily form complexes (i.e., lipoplexes) with the negatively charged phosphate backbones of nucleic acids. In 2015, Kono formed lipoplexes with genes encoding for IFN‐γ, which led to the induction of antigen‐specific CTLs when codelivered with OVA . The following year, Sahin and co‐workers created a lipoplex system to deliver RNA encoding for a neoantigen to dendritic cells to induce potent antigen‐specific CTL responses against melanoma .…”

Section: Nanoscale Materials For Immunotherapymentioning

confidence: 99%

Materials for Immunotherapy

et al. 2019

View full text Add to dashboard Cite

Breakthroughs in materials engineering have accelerated the progress of immunotherapy in preclinical studies. The interplay of chemistry and materials has resulted in improved loading, targeting, and release of immunomodulatory agents. An overview of the materials that are used to enable or improve the success of immunotherapies in preclinical studies is presented, from immunosuppressive to proinflammatory strategies, with particular emphasis on technologies poised for clinical translation. The materials are organized based on their characteristic length scale, whereby the enabling feature of each technology is organized by the structure of that material. For example, the mechanisms by which i) nanoscale materials can improve targeting and infiltration of immunomodulatory payloads into tissues and cells, ii) microscale materials can facilitate cell‐mediated transport and serve as artificial antigen‐presenting cells, and iii) macroscale materials can form the basis of artificial microenvironments to promote cell infiltration and reprogramming are discussed. As a step toward establishing a set of design rules for future immunotherapies, materials that intrinsically activate or suppress the immune system are reviewed. Finally, a brief outlook on the trajectory of these systems and how they may be improved to address unsolved challenges in cancer, infectious diseases, and autoimmunity is presented.

show abstract

Section: Nanoscale Materials For Immunotherapymentioning

confidence: 99%

Materials for Immunotherapy

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Kono and colleagues developed pHsensitive liposome complexes containing pH-sensitive 3-methylglutarylated poly(glycidol)-polymers which were protonated in endosomes; these triggered membrane fusion between liposomes and the endosomal membrane, leading to the efficient endosomal escape of cargos such antigens and plasmid DNAs (pDNAs) into cytosol in dendritic cells. 30) In addition to the pH gradient, the intracellular reducing environment is considered an alternative source for stimulating triggers. Intracellular glutathione (GSH) concentrations usually ranges from 0.5 to 10 mM, whereas extracellular values are one to three orders of magnitude lower.…”

Section: Activation In Response To Endogenous/internal Stimulimentioning

confidence: 99%

Recent Advances in Endogenous and Exogenous Stimuli-Responsive Nanocarriers for Drug Delivery and Therapeutics

Hatakeyama

2017

Chem. Pharm. Bull.

View full text Add to dashboard Cite

Significant progress has been achieved in the development of stimuli-responsive nanocarriers for drug delivery, diagnosis, and therapy. Various types of triggers are utilized in the development of nanocarrier delivery. Endogenous factors such as changes in pH, redox, gradient, and enzyme concentration which are linked to disease progression have been utilized for controlling biodistribution and releasing drugs from nanocarriers, as well as increasing subsequent pharmacological activity at the disease site. Nanocarriers which respond to artificially-induced exogenous factors (such as temperature, light, magnetic field, and ultrasound) have also been developed. This review aims to discuss recent advances in the design of stimuliresponsive nanocarriers which appear to have a promising future in medicine.

show abstract

“…After fusion with the endosomal membrane, the particle can deliver antigens into the cytoplasm. These antigens can subsequently be presented to CD8+ T‐cells and induce cytotoxic T‐lymphocytes . In pH sensitive galactosyl dextran‐retinal nanogels, it is hypothesized that the cleavage of hydrazone bonds at acidic pH both disassemble the nanogel and induce lysosomal rupture by the proton sponge effect .…”

Section: Improving Nanoparticle Design To Enhance Immunotherapy Efficacymentioning

confidence: 99%

“…These antigens can subsequently be presented to CD81 T-cells and induce cytotoxic T-lymphocytes. 51 In pH sensitive galactosyl dextran-retinal nanogels, it is hypothesized that the cleavage of hydrazone bonds at acidic pH both disassemble the nanogel and induce lysosomal rupture by the proton sponge effect. 52 Micelleplexes that disrupt the lysosomal membrane by two separate mechanisms have also been developed.…”

Section: Tailoring the Intracellular Delivery Of Nanoparticle Immunmentioning

confidence: 99%

Engineering nanoparticles to overcome barriers to immunotherapy

Toy

Roy

2016

Bioengineering & Transla Med

129

View full text Add to dashboard Cite

Advances in immunotherapy have led to the development of a variety of promising therapeutics, including small molecules, proteins and peptides, monoclonal antibodies, and cellular therapies. Despite this wealth of new therapeutics, the efficacy of immunotherapy has been limited by challenges in targeted delivery and controlled release, that is, spatial and temporal control on delivery. Particulate carriers, especially nanoparticles have been widely studied in drug delivery and vaccine research and are being increasingly investigated as vehicles to deliver immunotherapies. Nanoparticle‐mediated drug delivery could provide several benefits, including control of biodistribution and transport kinetics, the potential for site‐specific targeting, immunogenicity, tracking capability using medical imaging, and multitherapeutic loading. There are also a unique set of challenges, which include nonspecific uptake by phagocytic cells, off‐target biodistribution, permeation through tissue (transport limitation), nonspecific immune‐activation, and poor control over intracellular localization. This review highlights the importance of understanding the relationship between a nanoparticle's size, shape, charge, ligand density and elasticity to its vascular transport, biodistribution, cellular internalization, and immunogenicity. For the design of an effective immunotherapy, we highlight the importance of selecting a nanoparticle's physical characteristics (e.g., size, shape, elasticity) and its surface functionalization (e.g., chemical or polymer modifications, targeting or tissue‐penetrating peptides) with consideration of its reactivity to the targeted microenvironment (e.g., targeted cell types, use of stimuli‐sensitive biomaterials, immunogenicity). Applications of this rational nanoparticle design process in vaccine development and cancer immunotherapy are discussed.

show abstract

pH-sensitive polymer-liposome-based antigen delivery systems potentiated with interferon-γ gene lipoplex for efficient cancer immunotherapy

Cited by 83 publications

References 45 publications

Materials for Immunotherapy

Materials for Immunotherapy

Recent Advances in Endogenous and Exogenous Stimuli-Responsive Nanocarriers for Drug Delivery and Therapeutics

Engineering nanoparticles to overcome barriers to immunotherapy

Contact Info

Product

Resources

About