pH-sensitive polymers for cytoplasmic drug delivery

Abstract

To cite this article: Jaleh Varshosaz PhD (2008) pH-sensitive polymers for cytoplasmic drug delivery, Expert Opinion on Therapeutic Patents, 18:8,[959][960][961][962] To link to this article: http://dx.The pH-sensitive drug delivery systems could be triggered by a mild acidic environment, such as that occurring in solid tumors, inflammatory tissues and intracellular endosomal compartments. Moreover, the cytoplasmic delivery of internalized macromolecules (such as oligonucleic acid, siRNA, DNA, proteins and polymer-antibody complex) will be possible. Synthetic polymers -such as polyanions (acrylic acid derivatives) and polycations (poly ethylenimine and chitosan complexes) -are among the most popular compounds studied for intracellular trafficking of drugs. As research is progressing in the area of cytoplasmic delivery, many novel and innovative applications making use of the unique properties of pH-sensitive polymers are expected in the future. Expert Opin. Ther. Patents (2008) 18(8):959-962 10. Oh KT, Lee ES, Kim D, Bae YH. L-histidine-based pH-sensitive anticancer drug carrier micelle: reconstitution and brief evaluation of its systemic toxicity. Int J Pharm 2008 ; 358 (1-2): 177 -8311. Sethuraman VA, Bae YH. TAT peptide-based micelle system for potential active targeting of anti-cancer agents to acidic solid tumors.

Pharmacological and toxicological target organelles and safe use of single-walled carbon nanotubes as drug carriers in treating Alzheimer disease

“…Lysosomes, with an interior pH lower than that in cytoplasm, are favorable targets for drug delivery, especially for pH-sensitive target drug delivery systems, in which the drug release can be triggered by a mild acidic environment, such as that occurring in solid tumors and inflammatory tissues. [45][46][47] SWCNT-ACh was such a pHsensitive drug delivery system that successfully delivered ACh into brain with good curative effects on experimental AD, providing good evidence for lysosomes as the pharmacological target organelles of SWCNTs. The selective distribution of SWCNTs in the lysosomes in neurons and neurites is favorable for the release of ACh to develop transmitter function.…”