2019
DOI: 10.1016/j.ijpharm.2018.12.006
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pH-sensitive pullulan-doxorubicin nanoparticles loaded with 1,1,2-trichlorotrifluoroethane as a novel synergist for high intensity focused ultrasound mediated tumor ablation

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Cited by 22 publications
(9 citation statements)
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“…Pullulan polysaccharide is nontoxic, water-soluble, biocompatible, and easy to biodegrade and contains many active hydroxyl groups [21]. It is easy to connect hydrophobic groups by chemical modification such as esterification to form amphiphilic graft copolymers [22]. Previous study of cholesterol-modified pullulan polysaccharide showed that it has high loading capacity and a sustained-release effect [23].…”
Section: Introductionmentioning
confidence: 99%
“…Pullulan polysaccharide is nontoxic, water-soluble, biocompatible, and easy to biodegrade and contains many active hydroxyl groups [21]. It is easy to connect hydrophobic groups by chemical modification such as esterification to form amphiphilic graft copolymers [22]. Previous study of cholesterol-modified pullulan polysaccharide showed that it has high loading capacity and a sustained-release effect [23].…”
Section: Introductionmentioning
confidence: 99%
“…Besides drug delivery applications, the NE phase transition under US irradiation can facilitate energy deposition by HIFU to improve tumor ablation [ 337 ]. Zhang et al demonstrated that NEs could enhance the HIFU-mediated thermal ablation of tumors and efficiently accelerate the formation of HIFU thermal lesions.…”
Section: Reviewmentioning
confidence: 99%
“…Many studies have reported the synergistic effects of US irradiation and NE-based drug delivery or enhancement of imaging contrast [332]. These NEs can be modified or hybridized with different components to improve the properties and provide multifunctionality [130,[333][334][335][336][337].…”
Section: Nanoemulsions (Nanodroplets)mentioning
confidence: 99%
“…Recently, the chemical conjugation through hydrazone bond was used to generate peptide-dexamethasone and pullulan-dexamethasone conjugates that were investigated in vitro [10,26]. In contrast to the ocular field, polymeric drug conjugates have been widely investigated to provide site-specificity and extended drug release in some other medical indications [27][28][29][30][31][32].…”
Section: Introductionmentioning
confidence: 99%
“…Previously, pullulan has been used as a backbone in the synthesis of bioconjugates for drug delivery to the liver and pancreas [14,27,33,[35][36][37]. Conjugation of hydrophobic drugs to pullulan results in self-assembled colloids with drug molecules oriented to the core of the nanoparticles [27,28,33,35,36].…”
Section: Introductionmentioning
confidence: 99%