pH sensitive surfactant-stabilized Fe3O4 magnetic nanocarriers for dual drug delivery

Dutta, Binay K.; Shetake, Neena G.; Barick, B.K.; Barick, K. C.; Pandey, Badri N.; Priyadarsini, K. Indira; Hassan, P. A.

doi:10.1016/j.colsurfb.2017.11.054

Cited by 61 publications

(27 citation statements)

References 51 publications

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“…Over the last two years, the main anticancer drug coupled to IONPs was doxorubicin (DOX) [ 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 ]. This drug can be covalently bound to functionalized IONPs [ 123 ] or establish electrostatic interactions with negatively charged groups present in the magnetic nanocarriers [ 133 ]. A nanosystem with mesoporous hydroxyapatite (HA)-coated IONPs for DOX release was able to incorporate 93% of DOX from a concentration of 5 ppm [ 112 ].…”

Section: Drugs Bound To Ionpsmentioning

confidence: 99%

“…Alternative drugs may also be linked to nanosystems. Curcumin, a natural polyphenolic hydrophobic compound from Curcuma longa rhizomes, has been incorporated into IONPs for preventing and fighting cancer [ 10 , 106 , 133 , 173 , 174 , 175 ]. It is believed that this herbal product remains captured at the hydrophobic interface between components of surfactant-stabilized nanocarriers [ 133 ].…”

Section: Drugs Bound To Ionpsmentioning

confidence: 99%

“…Curcumin, a natural polyphenolic hydrophobic compound from Curcuma longa rhizomes, has been incorporated into IONPs for preventing and fighting cancer [ 10 , 106 , 133 , 173 , 174 , 175 ]. It is believed that this herbal product remains captured at the hydrophobic interface between components of surfactant-stabilized nanocarriers [ 133 ]. In this sense, Unterweger et al [ 176 ] proposed the use of photodynamic therapy associated with the hypericin photosensitizer (a component of the plant Hypericum perforatum or St. John’s wort, with antitumor properties), IONPs and dextran, concluding that this combination is a promising alternative for cancer treatment.…”

Section: Drugs Bound To Ionpsmentioning

confidence: 99%

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Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity

et al. 2018

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Medical applications and biotechnological advances, including magnetic resonance imaging, cell separation and detection, tissue repair, magnetic hyperthermia and drug delivery, have strongly benefited from employing iron oxide nanoparticles (IONPs) due to their remarkable properties, such as superparamagnetism, size and possibility of receiving a biocompatible coating. Ongoing research efforts focus on reducing drug concentration, toxicity, and other side effects, while increasing efficacy of IONPs-based treatments. This review highlights the methods of synthesis and presents the most recent reports in the literature regarding advances in drug delivery using IONPs-based systems, as well as their antimicrobial activity against different microorganisms. Furthermore, the toxicity of IONPs alone and constituting nanosystems is also addressed.

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Section: Drugs Bound To Ionpsmentioning

confidence: 99%

Section: Drugs Bound To Ionpsmentioning

confidence: 99%

Section: Drugs Bound To Ionpsmentioning

confidence: 99%

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Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity

et al. 2018

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“…Magnetic IONPs are specifically important for such a purpose—in that they are reported for targeted drug delivery in addition to cancer hyperthermia treatment and MRI [ 130 , 131 , 132 , 133 ]. These IONP-based nanocarriers are specific and effective in reducing the toxic effects on normal tissues [ 134 ], and they minimize the undesired interactions with other molecules [ 135 ]. The interaction bond between the anticancer drug“doxorubicin (DOX)” and IONPs is a covalent bond to create electrostatic interactions with negatively charged groups in magnetic nanocarriers and could be a promising nanosystem for acidic solid tumor treatment [ 136 , 137 ].…”

Section: Application Of Ionpsmentioning

confidence: 99%

Magnetic Iron Oxide Nanoparticle (IONP) Synthesis to Applications: Present and Future

et al. 2020

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Iron oxides are chemical compounds which have different polymorphic forms, including γ-Fe2O3 (maghemite), Fe3O4 (magnetite), and FeO (wustite). Among them, the most studied are γ-Fe2O3 and Fe3O4, as they possess extraordinary properties at the nanoscale (such as super paramagnetism, high specific surface area, biocompatible etc.), because at this size scale, the quantum effects affect matter behavior and optical, electrical and magnetic properties. Therefore, in the nanoscale, these materials become ideal for surface functionalization and modification in various applications such as separation techniques, magnetic sorting (cells and other biomolecules etc.), drug delivery, cancer hyperthermia, sensing etc., and also for increased surface area-to-volume ratio, which allows for excellent dispersibility in the solution form. The current methods used are partially and passively mixed reactants, and, thus, every reaction has a different proportion of all factors which causes further difficulties in reproducibility. Direct active and complete mixing and automated approaches could be solutions to this size- and shape-controlled synthesis, playing a key role in its exploitation for scientific or technological purposes. An ideal synthesis method should be able to allow reliable adjustment of parameters and control over the following: fluctuation in temperature; pH, stirring rate; particle distribution; size control; concentration; and control over nanoparticle shape and composition i.e., crystallinity, purity, and rapid screening. Iron oxide nanoparticle (IONP)-based available clinical applications are RNA/DNA extraction and detection of infectious bacteria and viruses. Such technologies are important at POC (point of care) diagnosis. IONPs can play a key role in these perspectives. Although there are various methods for synthesis of IONPs, one of the most crucial goals is to control size and properties with high reproducibility to accomplish successful applications. Using multiple characterization techniques to identify and confirm the oxide phase of iron can provide better characterization capability. It is very important to understand the in-depth IONP formation mechanism, enabling better control over parameters and overall reaction and, by extension, properties of IONPs. This work provides an in-depth overview of different properties, synthesis methods, and mechanisms of iron oxide nanoparticles (IONPs) formation, and the diverse range of their applications. Different characterization factors and strategies to confirm phase purity in the IONP synthesis field are reviewed. First, properties of IONPs and various synthesis routes with their merits and demerits are described. We also describe different synthesis strategies and formation mechanisms for IONPs such as for: wustite (FeO), hematite (α-Fe2O3), maghemite (ɤ-Fe2O3) and magnetite (Fe3O4). We also describe characterization of these nanoparticles and various applications in detail. In conclusion, we present a detailed overview on the properties, size-controlled synthesis, formation mechanisms and applications of IONPs.

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“…For example, the concurrent delivery of doxorubicin (DOX, one of the most active chemotherapeutics for cancer) and curcumin (CUR, a natural chemosensitizer with distinguishing abilities to inhibit P-gp overexpression and nuclear transcription factor NF-κB activation that are both closely linked to MDR) in one nanocarrier has been widely explored as an effective way to improve DOX treatment efficiency [ 18 , 19 , 20 , 21 ]. A variety of nanoparticulate delivery systems, such as liposomes or lipid NPs [ 21 , 22 , 23 , 24 ], polymeric micelles [ 25 , 26 , 27 ], prodrug NPs [ 28 , 29 , 30 ], as well as inorganic NPs [ 31 , 32 , 33 ], have been developed as codelivery vesicles for DOX/CUR. The codelivery of DOX/CUR with nanotechnology has achieved significant success in improving the therapeutic efficacy of DOX [ 18 , 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

A Modular Coassembly Approach to All-In-One Multifunctional Nanoplatform for Synergistic Codelivery of Doxorubicin and Curcumin

Yang

Guo

et al. 2018

Nanomaterials

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Synergistic combination therapy by integrating chemotherapeutics and chemosensitizers into nanoparticles has demonstrated great potential to reduce side effects, overcome multidrug resistance (MDR), and thus improve therapeutic efficacy. However, with regard to the nanocarriers for multidrug codelivery, it remains a strong challenge to maintain design simplicity, while incorporating the desirable multifunctionalities, such as coloaded high payloads, targeted delivery, hemodynamic stability, and also to ensure low drug leakage before reaching the tumor site, but simultaneously the corelease of drugs in the same cancer cell. Herein, we developed a facile modular coassembly approach to construct an all-in-one multifunctional multidrug delivery system for the synergistic codelivery of doxorubicin (DOX, chemotherapeutic agent) and curcumin (CUR, MDR modulator). The acid-cleavable PEGylated polymeric prodrug (DOX-h-PCEC), tumor cell-specific targeting peptide (CRGDK-PEG-PCL), and natural chemosensitizer (CUR) were ratiometrically assembled into in one single nanocarrier (CUR/DOX-h-PCEC@CRGDK NPs). The resulting CUR/DOX-h-PCEC@CRGDK NPs exhibited several desirable characteristics, such as efficient and ratiometric drug loading, high hemodynamic stability and low drug leakage, tumor intracellular acid-triggered cleavage, and subsequent intracellular simultaneous drug corelease, which are expected to maximize a synergistic effect of chemotherapy and chemosensitization. Collectively, the multifunctional nanocarrier is feasible for the creation of a robust nanoplatform for targeted multidrug codelivery and efficient MDR modulation.

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pH sensitive surfactant-stabilized Fe3O4 magnetic nanocarriers for dual drug delivery

Cited by 61 publications

References 51 publications

Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity

Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity

Magnetic Iron Oxide Nanoparticle (IONP) Synthesis to Applications: Present and Future

A Modular Coassembly Approach to All-In-One Multifunctional Nanoplatform for Synergistic Codelivery of Doxorubicin and Curcumin

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