pH stimuli drug loading/release platforms from LbL single/blend films: QCM-D and in-vitro studies

Aykut, Dilara Yılmaz; Yolaçan, Öznur; Deligöz, Hüseyin

doi:10.1016/j.colsurfa.2020.125113

Cited by 17 publications

(18 citation statements)

References 75 publications

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“…QCM-D sensor was firstly washed with a solution as we described previously. 49 Briefly, the sensor was cleaned with a mixture of ultra-pure water-ammonia (25%) and hydrogen peroxide (35%) (5:1:1 v/v) and heated up to 75 C for 5 min. Subsequently, the sensor was treated in a UV/Ozone chamber prior to use for 10 min to remove any contamination and hydroxylate the surfaces to provide binding sites on the surface for the first layer.…”

Section: Qcm-d Study Of the Multilayers Fabricationmentioning

confidence: 99%

“…48 The salt solution, seawater, and surfactant stability of the LbL films of different single/blends PEs were investigated using Quartz Crystal Microbalance-Dissipation (QCM-D) technique. 49 Also, the long-term physical and chemical stability of the LbL multilayers under NaOCl exposure was investigated for nanofiltration (NF) by QCM-D. 50 Furthermore, Lutkenhaus et al studied the impact of monovalent ions on the swelling behavior of LbL assembled films. They examined the effects of specific monovalent salts such as KBr, NaBr, NaCl, and KCl on the ion exchange response, swelling, and deswelling of the multilayers.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the multilayer stability and swelling properties of the LbL single/blend films were examined for drug loading and release studies as a function of pH. 49 Even though the sorption behavior of many drugs within the LbL films has been investigated, the drug/PE platforms where the drug is used as a negatively charged molecule and the effects of these platforms on film growth, drug adsorption, and layer stability have not been adequately studied up to our best knowledge. In this article, the growth of 10 bilayered PE/drug films, drug uptake, and multilayer stability was monitored at acidic, basic, and neutral conditions using QCM-D analysis as well as their surface properties.…”

Section: Introductionmentioning

confidence: 99%

“…According to one of our earlier published studies, PDADMAC-based LbL films had the highest drug loading and that is why PDADMAC was intentionally selected as a cationic PE while ibuprofen sodium (IBFNa) and diclofenac sodium (DCFNa), non-steroid antiinflammatory model drugs (NSAIDs) were used. 49…”

Section: Introductionmentioning

confidence: 99%

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Examining layer‐by‐layer assembly of polyelectrolyte‐drug interactions using Quartz Crystal Microbalance with Dissipation

Yilmaz‐Aykut,

Deligöz

2023

Polymer Engineering & Sci

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The incorporation of drug molecules into layer‐by‐layer (LbL) assemblies attracts great interest in biomedical applications. This work describes the preparation and characterization of LbL multilayers including drugs, namely ibuprofen (IBF‐Na) and Diclofenac sodium salt (DCF‐Na) as anionic molecules. The main aim is to enhance the drug loading capacity within the LbL assembly. The effects of drug‐LbL multilayered films obtained from poly(diallyl dimethylammonium chloride) (PDADMAC)/IBF‐Na and PDADMAC/DCF‐Na interactions on multilayer growth and loading of model molecules are examined using UV‐Visible and Quartz‐Crystal Microbalance with Dissipation (QCM‐D). The wet mass of PDADMAC/IBF‐Na is found to be 67.2 ng/cm2, while PDADMAC/DCF‐Na film exhibits 201.6 ng/cm2 mass adsorption. Furthermore, the multilayer stabilities are assessed against neutral, acidic, and basic solutions. The results demonstrate that the LbL films have robustness, without any signs of multilayer degradation. By the way, the incorporation of IBF‐Na into the feed solution leads to the formation of a rigid structure, whereas the inclusion of DCF‐Na results in a comparatively flexible structure. The use of a higher molecular weight and more polar drug in the feed causes a noticeable rise in surface hydrophilicity and surface roughness. PDADMAC/IBF‐Na and PDADMAC/DCF‐Na display average contact angles of 46 ± 1.3° and 76 ± 2° while they have roughness values of 5.9 and 8.0 nm, respectively. LbL multilayers fabricated from a polycation and anionic drug can be considered as a promising material platform for controlled drug loading due to their tunable physicochemical and morphological properties as well as surface wettability.

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Section: Qcm-d Study Of the Multilayers Fabricationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Examining layer‐by‐layer assembly of polyelectrolyte‐drug interactions using Quartz Crystal Microbalance with Dissipation

Yilmaz‐Aykut,

Deligöz

2023

Polymer Engineering & Sci

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“…An important challenge for biomimetics is creating surfaces and instruments for the delivery and controlled release of various drugs [ 10 ] and proteins. [ 11 ] This allows you to target damage to the body.…”

Section: Layer‐by‐layer Approachmentioning

confidence: 99%

Recent Progress of Layer‐by‐layer Assembly, Free‐Standing Film and Hydrogel Based on Polyelectrolytes

Ivanov

Pershina

Nikolaev

et al. 2021

Macromolecular Bioscience

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Nowadays, polyelectrolytes play an essential role in the development of new materials. Their use allows creating new properties of materials and surfaces and vary them in a wide range. Basically, modern methods are divided into three areas—the process of layer‐by‐layer deposition, free‐standing films, and hydrogels based on polyelectrolytes. Layer‐by‐layer assembly of polyelectrolytes on various surfaces is a powerful technique. It allows giving surfaces new properties, for example, protect them from corrosion. Free‐standing films are essential tools for the design of membranes and sensors. Hydrogels based on polyelectrolytes have recently shown their applicability in electrical and materials science. The creation of new materials and components with controlled properties can be achieved using polyelectrolytes. This review focuses on new technologies that have been developed with polyelectrolytes over the last five years.

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Physicochemical aspects of design of ultrathin films based on chitosan, pectin, and their silver nanocomposites with antiadhesive and bactericidal potential

Kulikouskaya

Zhdanko

Hileuskaya

et al. 2021

J Biomedical Materials Res

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Implant-related infection is one of the serious problems in regenerative medicine.Promising approach to overcome the problems caused by bacterial growth on the medical implants is their modification by bioactive coatings. A versatile technique for designing multilayer films with tailored characteristics at the nanometer scale is layer-by-layer assembly. In this study, multilayer films based on biopolymers (pectin and chitosan) and their nanocomposites with silver nanoparticles have been prepared and evaluated. The buildup of multilayers was monitored using the quartz crystal microbalance with dissipation technique. The morphology of the obtained films was investigated by atomic force microscopy. We have demonstrated that pectin-Agcontaining films were characterized by the linear growth and smooth defect-free surface. When pectin-Ag was substituted for the pectin in the multilayer systems, the properties of the formed coatings were significantly changed: the film rigidity and surface roughness increased, as well as the film growth acquired the parabolic character. All prepared multilayer films have shown antibacterial activity against gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria.The significant decrease in the number of the adhered E. coli on the multilayer surface has been determined; moreover, many of the cells were misshapen with cytoplasm leaking. The prepared multilayer films showed a mild activity against S. aureus predominantly due to the antiadhesive effect. Our results indicate that antibacterial activity of biopolymer multilayers is determined by the film composition and physicochemical characteristics and can be associated with their antiadhesive and bactericidal behaviors.

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pH stimuli drug loading/release platforms from LbL single/blend films: QCM-D and in-vitro studies

Cited by 17 publications

References 75 publications

Examining layer‐by‐layer assembly of polyelectrolyte‐drug interactions using Quartz Crystal Microbalance with Dissipation

Examining layer‐by‐layer assembly of polyelectrolyte‐drug interactions using Quartz Crystal Microbalance with Dissipation

Recent Progress of Layer‐by‐layer Assembly, Free‐Standing Film and Hydrogel Based on Polyelectrolytes

Physicochemical aspects of design of ultrathin films based on chitosan, pectin, and their silver nanocomposites with antiadhesive and bactericidal potential

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