pH/temperature sensitive poly(ethylene glycol)-based biodegradable polyester block copolymer hydrogels

Huynh, Dai Phu; Shim, Woo Sun; Kim, Ji Heung; Lee, Sang Soo

doi:10.1016/j.polymer.2006.09.021

Cited by 60 publications

(43 citation statements)

References 27 publications

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“…Subsequently, OSM-PCGA-PEG-PCGA-OSM copolymers were synthesized. [80] The OSM-PCGA-PEG-PCGA-OSM hydrogel degraded at a faster rate than did the OSM-PCLA-PEG-PCLA-OSM copolymer hydrogel.…”

Section: Ph/temperature-sensitive Block Copolymer Hydrogelsmentioning

confidence: 92%

Injectable Biodegradable Hydrogels

Nguyen

Lee

2010

Macromolecular Bioscience

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Injectable biodegradable copolymer hydrogels, which exhibit a sol–gel phase transition in response to external stimuli, such as temperature changes or both pH and temperature (pH/temperature) alterations, have found a number of uses in biomedical and pharmaceutical applications, such as drug delivery, cell growth, and tissue engineering. These hydrogels can be used in simple pharmaceutical formulations that can be prepared by mixing the hydrogel with drugs, proteins, or cells. Such formulations are administered in a straightforward manner, through site‐specific control of release behavior, and the hydrogels are compatible with biological systems. This review will provide a summary of recent progress in biodegradable temperature‐sensitive polymers including polyesters, polyphosphazenes, polypeptides, and chitosan, and pH/temperature‐sensitive polymers such as sulfamethazine‐, poly(β‐amino ester)‐, poly(amino urethane)‐, and poly(amidoamine)‐based polymers. The advantages of pH/temperature‐sensitive polymers over simple temperature‐sensitive polymers are also discussed. A perspective on the future of injectable biodegradable hydrogels is offered.magnified image

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“…Subsequently, OSM-PCGA-PEG-PCGA-OSM copolymers were synthesized. [80] The OSM-PCGA-PEG-PCGA-OSM hydrogel degraded at a faster rate than did the OSM-PCLA-PEG-PCLA-OSM copolymer hydrogel.…”

Section: Ph/temperature-sensitive Block Copolymer Hydrogelsmentioning

confidence: 92%

Injectable Biodegradable Hydrogels

Nguyen

Lee

2010

Macromolecular Bioscience

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423

343

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“…The release rates of drugs from hydrogels are influenced by several factors, such as the hydrophilicity/hydrophobicity (solubility) and molecular weight of the drug, the degradation rates of the hydrogel, the mesh size of the network, and the diffusion constant of the drug in the hydrogel [13]. In general, temperature-responsive biodegradable IP hydrogels, once formed in the body, are likely to quickly revert to the sol state (typically in less than 24 h) at the injection site, where there is a large amount of body fluid [14].…”

Section: Introductionmentioning

confidence: 99%

Peptide Drug Release Behavior from Biodegradable Temperature-Responsive Injectable Hydrogels Exhibiting Irreversible Gelation

Takata¹,

Takai²,

Yoshizaki

et al. 2017

Gels

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Abstract:We investigated the release behavior of glucagon-like peptide-1 (GLP-1) from a biodegradable injectable polymer (IP) hydrogel. This hydrogel shows temperature-responsive irreversible gelation due to the covalent bond formation through a thiol-ene reaction. In vitro sustained release of GLP-1 from an irreversible IP formulation (F(P1/D+PA 40 )) was observed compared with a reversible (physical gelation) IP formulation (F(P1)). Moreover, pharmaceutically active levels of GLP-1 were maintained in blood after subcutaneous injection of the irreversible IP formulation into rats. This system should be useful for the minimally invasive sustained drug release of peptide drugs and other water-soluble bioactive reagents.

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“…The pH of these samples was adjusted with NaOH 5 M and HCl 5 M. The sol-gel transition at each temperature was determined by angling the vial horizontally after keeping it at a constant temperature for 10 min, as described in our previous papers. 24,25 Insulin Loading Process. Copolymer solutions were prepared by dissolving triblock or pentablock in PBS (contain 2 v% of HCl 37%) at 2 o C, pH of these solutions could be adjusted by NaOH 5 M and HCl 5 M at 2 o C.…”

Section: Synthesis Of Pae-pcl-peg-pcl-pae Pentablock Copolymersmentioning

confidence: 99%

Controlling the degradation of pH/temperature-sensitive injectable hydrogels based on poly(β-amino ester)

2010

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Poly (ethylene glycol) (PEG) -poly(ε-caprolactone(CL)-co-D,L-lactide (LA)) (PCLA-PEG-PCLA) was synthesized by ring-opening polymerization to form a temperature sensitive hydrogel triblock copolymer. Poly(β-amino ester) (PAE) obtained from 1,4-butanediol diacrylate (BDA), and 4,4'-trimethylene dipiperidine (TMDP) was used as a pH sensitive moiety to conjugate to the triblock copolymer. The physicochemical properties of the temperature-sensitive triblock and pH/temperature-sensitive pentablock copolymers (PAE-PCLA-PEG-PCLA-PAE) were characterized by 1 H NMR spectroscopy and gel permeation spectroscopy. The sol-gel phase transition behavior of the PAE-PCLA-PEG-PCLA-PAE block copolymers was investigated. An aqueous solution of the copolymers (20 wt%) changed from a sol phase at pH 6.4 and 10 o C to a gel phase at pH 7.4 and 37 o C. In addition, the degradation of PAE-PCLA-PEG-PCLA-PAE was compared with that of poly(ethylene glycol) -poly(ε-caprolactone) -poly (β-amino ester) (PAE-PCL-PEG-PCL-PAE) using both in vitro and in vivo experiments. The relationship between the insulin release profile from the matrix and the degradation of these materials also investigated.

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pH/temperature sensitive poly(ethylene glycol)-based biodegradable polyester block copolymer hydrogels

Cited by 60 publications

References 27 publications

Injectable Biodegradable Hydrogels

Injectable Biodegradable Hydrogels

Peptide Drug Release Behavior from Biodegradable Temperature-Responsive Injectable Hydrogels Exhibiting Irreversible Gelation

Controlling the degradation of pH/temperature-sensitive injectable hydrogels based on poly(β-amino ester)

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