Phage as versatile nanoink for printing 3-D cell-laden scaffolds

Lee, Doe-Young; Lee, Hyeongjin; Kim, YongBok; Yoo, So Young; Chung, Woo‐Jae; Kim, GeunHyung

doi:10.1016/j.actbio.2015.10.004

Cited by 68 publications

(33 citation statements)

References 48 publications

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“…Hence, the variables in the projects are decreased and the outcome is more likely to be predicted. As an example, RGD-phage solution was employed in one study to develop a versatile bioink with cell printing ability [25] . In particular, M13 phages were shown to provide good blending properties with alginate.…”

Section: Extrusion-based Bioprintingmentioning

confidence: 99%

3D bioprinting for biomedical devices and tissue engineering: A review of recent trends and advances

Derakhshanfar

Mbeleck

et al. 2018

Bioactive Materials

849

567

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3D printing, an additive manufacturing based technology for precise 3D construction, is currently widely employed to enhance applicability and function of cell laden scaffolds. Research on novel compatible biomaterials for bioprinting exhibiting fast crosslinking properties is an essential prerequisite toward advancing 3D printing applications in tissue engineering. Printability to improve fabrication process and cell encapsulation are two of the main factors to be considered in development of 3D bioprinting. Other important factors include but are not limited to printing fidelity, stability, crosslinking time, biocompatibility, cell encapsulation and proliferation, shear-thinning properties, and mechanical properties such as mechanical strength and elasticity. In this review, we recite recent promising advances in bioink development as well as bioprinting methods. Also, an effort has been made to include studies with diverse types of crosslinking methods such as photo, chemical and ultraviolet (UV). We also propose the challenges and future outlook of 3D bioprinting application in medical sciences and discuss the high performance bioinks.

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Section: Extrusion-based Bioprintingmentioning

confidence: 99%

3D bioprinting for biomedical devices and tissue engineering: A review of recent trends and advances

Derakhshanfar

Mbeleck

et al. 2018

Bioactive Materials

849

567

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“…Researchers show that the presence of phages in the human body is bioneutral, which is encouraging for their application. The application of phage display substrates in scaffolds was already shown in many materials designed for the regeneration of different tissues (i.e., cartilage, bone, or neural) [ 113 , 160 , 161 , 162 , 163 , 164 , 165 , 166 ].…”

Section: Bacteriophages In Materials Sciencementioning

confidence: 99%

Application of Bacteriophages in Nanotechnology

Paczesny

Bielec

2020

Nanomaterials

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Bacteriophages (phages for short) are viruses, which have bacteria as hosts. The single phage body virion, is a colloidal particle, often possessing a dipole moment. As such, phages were used as perfectly monodisperse systems to study various physicochemical phenomena (e.g., transport or sedimentation in complex fluids), or in the material science (e.g., as scaffolds). Nevertheless, phages also execute the life cycle to multiply and produce progeny virions. Upon completion of the life cycle of phages, the host cells are usually destroyed. Natural abilities to bind to and kill bacteria were a starting point for utilizing phages in phage therapies (i.e., medical treatments that use phages to fight bacterial infections) and for bacteria detection. Numerous applications of phages became possible thanks to phage display—a method connecting the phenotype and genotype, which allows for selecting specific peptides or proteins with affinity to a given target. Here, we review the application of bacteriophages in nanoscience, emphasizing bio-related applications, material science, soft matter research, and physical chemistry.

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“…Conventional polymeric hydrogels and composites are frequently employed as inks in 3D bioprinting; however, Lee et al reported genetically engineered M13 phage as a versatile nanoink for 3D scaffold engineering (Figure ). The group used M13 phages, displaying integrin‐binding GRGDS (a peptide with H‐Gly‐Arg‐Gly‐Asp‐Ser‐OH sequence) and calcium‐binding (DDYD) domains on their surface to fabricate 3D‐MC3T3‐E1 cell‐laden scaffolds.…”

Section: Polymersmentioning

confidence: 99%

“…Schematic of the molecular design of the phages being used as a nanoink. Reproduced with permission from Lee et al Copyright Elsevier 2016…”

Section: Polymersmentioning

confidence: 99%

Multifaceted polymeric materials in three‐dimensional processing (3DP) technologies: Current progress and prospects

Oderinde

Kang

et al. 2018

Polymers for Advanced Techs

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Three‐dimensional printing (3DP) technologies, which are sets of powerful deposition methods employed to fabricate 3D objects with materials in the fields of material sciences and engineering, biomedical and biocompatible structural components, automotive, aviation, and polymers, among others, are currently rapidly developing manufacturing technologies. The methods have significant advantages, which include designing flexibility, enhanced geometrical freedom, low cost, and net shape manufacture, among others, over the traditional “subtractive” method. This review highlights the major 3D printing techniques, especially in the fields of advanced polymeric material fabrication and engineering, as well as the synergy in the incorporation of different types of polymeric materials and composites in a process that will lead to an enhancement of dimensional accuracy for 3D technologies. Furthermore, composite ink systems especially polymer‐based and hydrogel‐based in tissue engineering applications are also discussed.

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Phage as versatile nanoink for printing 3-D cell-laden scaffolds

Cited by 68 publications

References 48 publications

3D bioprinting for biomedical devices and tissue engineering: A review of recent trends and advances

3D bioprinting for biomedical devices and tissue engineering: A review of recent trends and advances

Application of Bacteriophages in Nanotechnology

Multifaceted polymeric materials in three‐dimensional processing (3DP) technologies: Current progress and prospects

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