Phage Display in Molecular Imaging and Diagnosis of Cancer

Deutscher, Susan L.

doi:10.1021/cr900317f

Cited by 197 publications

(154 citation statements)

References 174 publications

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“…[559] Through this cyclic selection process, desired peptide ligands, which range from 10-15 amino acids, with affinity for targets are collected and nonspecific binders are washed away. Specifically, peptide ligands for myriad of targets have been synthesized thanks to improved screening techniques and development of highly specific peptide phage libraries and plasmid peptide libraries.…”

Section: Peptidesmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

204

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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Section: Peptidesmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

204

171

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“…One intrinsic property of SWNTs is their ability to cross cellular membranes without eliciting cytotoxicity. 62 So as a unique quasi one-dimensional material, they have been explored as novel delivery vehicles for drugs, 63 proteins 64 and so on. Another intrinsic property of SWNTs is their strong optical absorbance in the NIR region, [65][66][67][68] which makes SWNTs appropriate to be used as agents for PAI.…”

Section: Carbon Npmentioning

confidence: 99%

“…Here, we refer NIR light-absorbing semiconducting polymer NPs: semiconducting polymer nanoparticles (SPNs) as a new class of contrast agents for PA molecular imaging. 62 Recently, SPNs have been transformed as e±-cient PA and°uorescent imaging nanomaterials. Speci¯cally, two semiconducting polymer derivatives, poly(cyclopentadithio-phene-alt-benzothiadiazole) (SP1) and poly(acenaphthothieno-pyrazine-altbenzodithiophene) (SP2), with molecular structure were used to prepare functional SPNs.…”

Section: Polymer Npsmentioning

confidence: 99%

Photoacoustic molecular imaging with functional nanoparticles

Qin

2017

J. Innov. Opt. Health Sci.

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Photoacoustic imaging (PAI) breaks through the optical di®usion limit by making use of the PA e®ect. By converting incident photons into ultrasonic waves, PAI combines high contrast of optical imaging and high spatial resolution in depth tissue of ultrasound imaging in a single imaging modality. This imaging modality has now shown potential for molecular imaging, which enables visualization of biological processes with systemically introduced functional nanoparticles. In the current review, the potentials of di®erent optical nanoprobes as PAI contrast agents were elucidated and discussed.

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“…These THPs can also be used to delivery chemical agents to the cancer site while with low affinity against the normal cells [61]. Here, we divide the THPs into three different types.…”

Section: Modification Strategy Targeting Modificationmentioning

confidence: 99%

Design and Modification of Anticancer Peptides

Hu¹,

Chen²,

Zhao³

et al. 2016

Drug Des

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Cancer is a great concern in the public health and development of novel therapeutic agent or strategy become urgently. Anticancer peptides (ACPs) have become promising anticancer drug candidate molecules due to their several extraordinary properties, such as small size, high activity, low immunogenicity, good biocompatibility, diversity of sequence and more modification sites for the functional molecules. However, the low stability and short half-life of peptides are the major barriers for the application. In this review, we focus on the methods of peptide design and modification to improve the stability, half-life time and specificity of ACPs, which including amino acid substitution, cyclization, hybridization, fragmentization, modification of C-and N-terminal of peptide by polymer or targeting molecules, etc.modification of C-and N-terminal of peptide by polymer or targeting molecules, etc. The schematic diagram of major design and modification strategies of ACPs are shown in Figure 1.

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Phage Display in Molecular Imaging and Diagnosis of Cancer

Cited by 197 publications

References 174 publications

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Photoacoustic molecular imaging with functional nanoparticles

Design and Modification of Anticancer Peptides

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