Phage therapy as a glimmer of hope in the fight against the recurrence or emergence of surgical site bacterial infections

Moghadam, Majid Taati; Mojtahedi, Ali; Salamy, Shakiba; Shahbazi, Razieh; Satarzadeh, Naghmeh; Delavar, Majid; Ashoobi, Mohammad Taghi

doi:10.1007/s15010-024-02178-0

Cited by 3 publications

(1 citation statement)

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“…Notably, phages have been effectively utilized in the treatment of postoperative infected wounds since the early 1940s and 1980s [74,75]. Recent studies have demonstrated the potential of phage therapy in managing surgical wound infections in both human patients and animals, as well as in eradicating biofilm and combating antibiotic-resistant infections in surgical wounds [76]. Leitner et al conducted a clinical trial in which 474 patients undergoing transurethral resection of the prostate were administered a combination of phage and antibiotic therapy [77].…”

Section: Surgical Wound Infectionsmentioning

confidence: 99%

Current Knowledge and Perspectives of Phage Therapy for Combating Refractory Wound Infections

Wang,

Du,

Dong

et al. 2024

IJMS

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Wound infection is one of the most important factors affecting wound healing, so its effective control is critical to promote the process of wound healing. However, with the increasing prevalence of multi-drug-resistant (MDR) bacterial strains, the prevention and treatment of wound infections are now more challenging, imposing heavy medical and financial burdens on patients. Furthermore, the diminishing effectiveness of conventional antimicrobials and the declining research on new antibiotics necessitate the urgent exploration of alternative treatments for wound infections. Recently, phage therapy has been revitalized as a promising strategy to address the challenges posed by bacterial infections in the era of antibiotic resistance. The use of phage therapy in treating infectious diseases has demonstrated positive results. This review provides an overview of the mechanisms, characteristics, and delivery methods of phage therapy for combating pathogenic bacteria. Then, we focus on the clinical application of various phage therapies in managing refractory wound infections, such as diabetic foot infections, as well as traumatic, surgical, and burn wound infections. Additionally, an analysis of the potential obstacles and challenges of phage therapy in clinical practice is presented, along with corresponding strategies for addressing these issues. This review serves to enhance our understanding of phage therapy and provides innovative avenues for addressing refractory infections in wound healing.

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Section: Surgical Wound Infectionsmentioning

confidence: 99%