PhageBox: An Open Source Digital Microfluidic Extension With Applications for Phage Discovery

Albin, Dreycey; Buecherl, Lukas; Kochavi, Eitan; Niehaus, Elise; Novack, Sasha; Uragoda, Shenali; Myers, Chris J.; Alistar, Mirela

doi:10.1109/tbme.2023.3295418

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2024

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A droplet robotic system enabled by electret-induced polarization on droplet

Zhang,

Fan

et al. 2024

Nat Commun

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Robotics for scientific research are evolving from grasping macro-scale solid materials to directly actuating micro-scale liquid samples. However, current liquid actuation mechanisms often restrict operable liquid types or compromise the activity of biochemical samples by introducing interfering mediums. Here, we propose a robotic liquid handling system enabled by a novel droplet actuation mechanism, termed electret-induced polarization on droplet (EPD). EPD enables all-liquid actuation in principle and experimentally exhibits generality for actuating various inorganic/organic liquids with relative permittivity ranging from 2.25 to 84.2 and volume from 500 nL to 1 mL. Moreover, EPD is capable of actuating various biochemical samples without compromising their activities, including various body fluids, living cells, and proteins. A robotic system is also coupled with the EPD mechanism to enable full automation. EPD’s high adaptability with liquid types and biochemical samples thus promotes the automation of liquid-based scientific experiments across multiple disciplines.

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