Phagocytic function of peripheral monocytes and neutrophils in ovarian cancer

Kovács, Ágnes Éva; Póka, Ròbert; Szűcs, Sándor; Pajor, László; Lampé, Rudolf

doi:10.1016/j.ejogrb.2018.08.198

Cited by 4 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…OPC also affects oxygen-dependent microbicidal systems of phagocytes (neutrophils) besides to oxygen-dependent anti-infective systems of phagocytosis. 2,3,[17][18][19] As already mentioned, a decrease in the production of proinflammatory cytokines by neutrophils, monocytes, macrophages (and, to a lesser extent, other cells of the immune system) is due to the cholinergic anti-inflammatory pathway (activated by acetylcholine α7nAChRs cells) under the influence of cholinergic stimulation PMS, leading to a reduction in the synthesis of pro-inflammatory cytokines). 2,3,7,8,10,11,15,16 Probably a decrease the production of these cytokines during intoxication OPC is not only induced as a result of the mechanisms associated with the cholinergic anti-inflammatory pathway.…”

Section: Discussionmentioning

confidence: 96%

“…S. aureus 209P was used to assess the phagocytic index and the phagocytic number. 2,3,17,18 Parameters of cellular immune reactions were assessed by generally accepted methods in experimental immunotoxicology and immunology 2,3,19 after chronic intoxication of OPC 30 days after the first injection of organophosphorous substances. The activity of natural killer (NK) was determined by the index of natural cytotoxicity spectrophotometrically.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

The effect of chronic intoxication by organophosphate insecticides on the parameters of innate and adaptive immunity and realization of the cholinergic anti-inflammatory pathway

Забродский¹

2018

PPIJ

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 96%

Section: Methodsmentioning

confidence: 99%

The effect of chronic intoxication by organophosphate insecticides on the parameters of innate and adaptive immunity and realization of the cholinergic anti-inflammatory pathway

Забродский¹

2018

PPIJ

View full text Add to dashboard Cite

show abstract

“…For instance, Dai et al demonstrated that sustained Th1 response was important for tumor regression and cure ( 41 ), while Li et al discovered that NSCLC prognosis was involved in a signature of tumor-immune microenvironment genes ( 42 ). Another study on ovarian cancer performed by Kovács et al found the phagocytic function of monocytes and neutrophil granulocytes to be reduced ( 43 ). Furthermore, among the 6 immune subtypes, C1 had a high proliferation rate, with a higher percentage of C1 in cancer patients suggesting a tumor-promoting state, which is in line with our results.…”

Section: Discussionmentioning

confidence: 99%

LncRNA FENDRR-mediated tumor suppression and tumor-immune microenvironment changes in non-small cell lung cancer

Pan¹,

Yu²,

Sun³

et al. 2020

Transl Cancer Res TCR

View full text Add to dashboard Cite

Background Long noncoding RNAs (lncRNAs) play a key role in the development and progression of many cancer types, including lung cancer. The objective of this study is to examine the function and molecular mechanism of lncRNAs involved in non-small cell lung cancer (NSCLC). Methods First, 7 lung cancer-related differentially expressed LncRNAs were screened from 2 genomic profiling datasets. Of these lncRNAs, FOXF1 adjacent noncoding developmental regulatory RNA (FENDRR) was found to be the only one that was both significantly down-regulated in the patients with advanced pathology and negatively correlated with prognosis. Thus, lncRNA FENDRR was further studied in this project. Clinical correlation analysis was further conducted in the GSE30219 dataset and 73 paired lung cancer and noncancerous tissues stored in our lab; Subsequently, we evaluated FENDRR coding potential with the Phylogenetic Codon Substitution Frequencies (PhyloCSF), Coding-Potential Assessment Tool (CPAT), and Coding Potential Calculator (CPC) online analytical tool. The cell growth ability was measured by CCK8 assay and clonogenicity assay, the metastatic capacities were evaluated using Transwell migration and invasion assays. Mechanistically, we analyzed the correlation of FENDRR function in NSCLC with immune response by utilizing The Cancer Genome Atlas (TCGA) data. Results Results indicated a negative clinical correlation of FENDRR. Coding potential analysis showed FENDRR as a noncoding RNA. Elevated expression of FENDRR led to cell growth arrest, inhibition of proliferative ability, declined migration and invasion potential of NSCLC cells in vitro . Mechanistically, we discovered that FENDRR expression might be involved in aberrant immune response regulation. Conclusions Taken together, our results provide a greater understanding of lncRNA FENDRR as a tumor suppressor with respect to tumor-immune interactions in NSCLC.

show abstract

“…In recent years, host immune and inflammatory responses have been considered as a marker of cancer progression and prognosis, [19][20][21][22] which can be evaluated by hematological parameters, such as monocyte-to-lymphocyte ratio (MLR) and the absolute monocyte count (AMC). Monocytes play an important role in the inflammatory response produced by tumors.…”

Section: Introductionmentioning

confidence: 99%

A Survival Prediction Nomogram for Esophageal Squamous Cell Carcinoma Treated with Neoadjuvant Chemoradiotherapy Followed by Surgery

Ding¹,

Liu²,

Huang³

et al. 2021

CMAR

View full text Add to dashboard Cite

Background: Neoadjuvant chemoradiotherapy (NCRT) followed by surgery is a component of the standard treatment for resectable locally advanced esophageal squamous cell carcinoma (ESCC), and the parameters for survival prediction are not clear yet. Our study aimed to construct a survival prediction nomogram for ESCC with NCRT followed by surgery. Methods: We analyzed hematological parameters and related-derivative indexes from 122 ESCC patients treated with NCRT followed by surgery. Univariate and multivariate Cox survival analyses were performed to identify independent prognostic factors to establish a nomogram and predict overall survival (OS). The predictive value of the nomogram for OS was evaluated by the concordance index (C-index), decision curve analysis (DCA), the clinical impact curve (CIC), net reclassification improvement (NRI), and integrated discrimination improvement (IDI). Results: The pretreatment nutritional candidate, prognostic nutrition index, inflammationrelated absolute monocyte count and TNM staging were entered into the nomogram for ESCC with NCRT followed by surgery. The C-index of the nomogram for OS was 0.790 (95% CI = 0.688-0.893), which was higher than that of TNM staging (0.681; 95% CI = 0.565-0.798, P = 0.026). The DCA, CIC, NRI, and IDI of the nomogram showed moderate improvement in predicting survival. Based on the cut point calculated according to the constructed nomogram, the high-risk group had poorer OS than that of the low-risk group (P < 0.05). Conclusion:A novel nomogram based on nutrition-and inflammation-related indicators might help predict the survival of ESCC treated with NCRT followed by surgery.

show abstract

Phagocytic function of peripheral monocytes and neutrophils in ovarian cancer

Cited by 4 publications

References 0 publications

The effect of chronic intoxication by organophosphate insecticides on the parameters of innate and adaptive immunity and realization of the cholinergic anti-inflammatory pathway

The effect of chronic intoxication by organophosphate insecticides on the parameters of innate and adaptive immunity and realization of the cholinergic anti-inflammatory pathway

LncRNA FENDRR-mediated tumor suppression and tumor-immune microenvironment changes in non-small cell lung cancer

A Survival Prediction Nomogram for Esophageal Squamous Cell Carcinoma Treated with Neoadjuvant Chemoradiotherapy Followed by Surgery

Contact Info

Product

Resources

About