Phantom and cadaver measurements of dose and dose distribution in micro-CT of the chest in mice

Rodt, Thomas; Luepke, Matthias; Boehm, Claudia; Falck, Christian von; Stamm, Gilbert G.; Borlak, Jürgen; Seifert, H; Galanski, Michael

doi:10.1258/ar.2010.100059

Cited by 28 publications

(23 citation statements)

References 27 publications

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“…Currently, only micro-CT is utilized to this end detect lung tumors in mice, applying doses of 170–280 mGy per scan 7 . Here, concerns arise with respect to adverse radiation-induced side effects which may falsify the outcome of long-term studies 7 . Conventional x-ray radiography has not been used in small-animal experiments due to the lack in sensitivity.…”

Section: Discussionmentioning

confidence: 99%

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X-ray Dark-field Radiography - In-Vivo Diagnosis of Lung Cancer in Mice

Scherer

Yaroshenko

Bölükbas

et al. 2017

Sci Rep

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Accounting for about 1.5 million deaths annually, lung cancer is the prevailing cause of cancer deaths worldwide, mostly associated with long-term smoking effects. Numerous small-animal studies are performed currently in order to better understand the pathogenesis of the disease and to develop treatment strategies. Within this letter, we propose to exploit X-ray dark-field imaging as a novel diagnostic tool for the detection of lung cancer on projection radiographs. Here, we demonstrate in living mice bearing lung tumors, that X-ray dark-field radiography provides significantly improved lung tumor detection rates without increasing the number of false-positives, especially in the case of small and superimposed nodules, when compared to conventional absorption-based imaging. While this method still needs to be adapted to larger mammals and finally humans, the technique presented here can already serve as a valuable tool in evaluating novel lung cancer therapies, tested in mice and other small animal models.

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Section: Discussionmentioning

confidence: 99%

“…Micro-CT can help localize the tumors, but it has a disadvantage of delivering quite a substantial dose to the animal. Accumulation of the dose can therefore bias or even falsify the results of the study 7 .…”

Section: Introductionmentioning

confidence: 99%

X-ray Dark-field Radiography - In-Vivo Diagnosis of Lung Cancer in Mice

Scherer

Yaroshenko

Bölükbas

et al. 2017

Sci Rep

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“…To acquire three-dimensional datasets, CBCT seems having some privilege over micro-CT or medical CT. First, CBCT can provide a relatively large scanning area while Micro CT only has a confined scan area in which one extracted tooth can be scanned at a time. Second, the radiation dose is high in a high resolution Micro-CT image [34]. Moreover, extracted teeth are needed for a Micro CT scan, which is not acceptable for a live person.…”

Section: Discussionmentioning

confidence: 99%

Age estimation based on pulp chamber volume of first molars from cone-beam computed tomography images

et al. 2015

Forensic Science International

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“…However, if a 2-cm wide detector ring is used, the imaging dose will decrease to 92 mGy, which is lower than the imaging doses typically delivered during microCT procedures. 17 Additionally, for imaging during proton radiotherapy, doses in the order of units of Gy will be high enough to result in high XRF signal.…”

Section: Discussionmentioning

confidence: 99%

Proton‐induced x‐ray fluorescence CT imaging

et al. 2015

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Purpose: To demonstrate the feasibility of proton-induced x-ray fluorescence CT (pXFCT) imaging of gold in a small animal sized object by means of experiments and Monte Carlo (MC) simulations. Methods: First, proton-induced gold x-ray fluorescence (pXRF) was measured as a function of gold concentration. Vials of 2.2 cm in diameter filled with 0%-5% Au solutions were irradiated with a 220 MeV proton beam and x-ray fluorescence induced by the interaction of protons, and Au was detected with a 3 × 3 mm 2 CdTe detector placed at 90• with respect to the incident proton beam at a distance of 45 cm from the vials. Second, a 7-cm diameter water phantom containing three 2.2-diameter vials with 3%-5% Au solutions was imaged with a 7-mm FWHM 220 MeV proton beam in a first generation CT scanning geometry. X-rays scattered perpendicular to the incident proton beam were acquired with the CdTe detector placed at 45 cm from the phantom positioned on a translation/rotation stage. Twenty one translational steps spaced by 3 mm at each of 36 projection angles spaced by 10• were acquired, and pXFCT images of the phantom were reconstructed with filtered back projection. A simplified geometry of the experimental data acquisition setup was modeled with the MC TOPAS code, and simulation results were compared to the experimental data. Results: A linear relationship between gold pXRF and gold concentration was observed in both experimental and MC simulation data (R 2 > 0.99). All Au vials were apparent in the experimental and simulated pXFCT images. Specifically, the 3% Au vial was detectable in the experimental [contrast-to-noise ratio (CNR) = 5.8] and simulated (CNR = 11.5) pXFCT image. Due to fluorescence x-ray attenuation in the higher concentration vials, the 4% and 5% Au contrast were underestimated by 10% and 15%, respectively, in both the experimental and simulated pXFCT images.

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Phantom and cadaver measurements of dose and dose distribution in micro-CT of the chest in mice

Cited by 28 publications

References 27 publications

X-ray Dark-field Radiography - In-Vivo Diagnosis of Lung Cancer in Mice

X-ray Dark-field Radiography - In-Vivo Diagnosis of Lung Cancer in Mice

Age estimation based on pulp chamber volume of first molars from cone-beam computed tomography images

Proton‐induced x‐ray fluorescence CT imaging

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