Pharmaceutical application of multivariate modelling techniques: a review on the manufacturing of tablets

Shi, Guolin; Lin, Liwu; Liu, Yuling; Chen, Gongsen; Luo, Yuting; Wu, Yanqiu; Li, Hui

doi:10.1039/d0ra08030f

Cited by 19 publications

(5 citation statements)

References 292 publications

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“…In addition, in order to optimize the coating process, mathematical modeling (e.g., computational fluid dynamics (CFD), the discrete element method (DEM), and Monte Carlo methods) is also used to determine the thicknesses and porosities of the shells in fluidized bed coatings [38].…”

Section: Discussionmentioning

confidence: 99%

The Use of Novel, Rapid Analytical Tools in the Assessment of the Stability of Tablets—A Pilot Analysis of Expired and Unexpired Tablets Containing Nifuroxazide

Sarecka-Hujar

Szulc-Musioł²,

Meisner³

et al. 2022

Processes

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In the analysis of finished pharmaceutical products, numerous innovative analytical techniques are often used, i.e., Raman spectroscopy, scanning electron microscopy, computer microtomography, directional hemispherical reflectance, and hyperspectral analyses. These techniques allow for the identification of changes in solid phases. Many advantages over other techniques can be attributed to these techniques, e.g., they are rapid, non-destructive, and comprehensive. They allow for the identification of changes occurring in solid phases. However, the above-mentioned methods are still not standard procedures in pharmaceutical research. The present study aimed to assess the possible usefulness of total directional hemispherical reflectance (THR), hyperspectral imaging, and computer microtomography to evaluate the stability of tablets containing nifuroxazide during storage. In the study, expired and unexpired coating tablets containing nifuroxazide (n = 10 each) were analyzed. In addition, four unexpired tablets were stored at 40°C over 3 months (stressed tablets). Reflectance was determined with seven wavelength bands from 335 nm to 2500 nm using an SOC-410 Directional Hemispherical Reflectometer (Surface Optics Corporation, San Diego, CA, USA). A Specim IQ hyperspectral camera (Spectral Imaging Ltd., Oulu, Finland) was used with a wavelength range of 400–1030 nm. Tablets were also scanned using X-ray microtomography (Phoenix vǀtomeǀx, GE Sensing & Inspection Technologies GmbH, Wunstorf, Germany). The results indicated that total reflectance was lower in expired tablets than in unexpired tablets in all spectral bands, except for 700–1100 nm and 1700–2500 nm. In turn, the stressed tablets showed higher THR values than expired tablets in all spectral bands, except for 1000–1700 nm. In addition, hyperspectral analysis of the homogeneity of the tablets, as well as X-ray microtomographic analysis of tablet density and coating thickness, indicated that these parameters differed significantly between the analyzed tablets.

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Section: Discussionmentioning

confidence: 99%

The Use of Novel, Rapid Analytical Tools in the Assessment of the Stability of Tablets—A Pilot Analysis of Expired and Unexpired Tablets Containing Nifuroxazide

Sarecka-Hujar

Szulc-Musioł²,

Meisner³

et al. 2022

Processes

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“…Mechanistic models, such as the discrete element method (DEM), have been utilized for powder-related processes like milling, blending, granulation, and coating, enhancing process understanding and control (Dong et al, 2023;Russell & Capece, 2022). Multivariable modeling techniques have been employed in tablet manufacturing to optimize processes, monitor quality a ributes, and improve process control, especially in continuous manufacturing se ings (Shi et al, 2021). Additionally, simulation modeling frameworks have been developed for pharmaceutical tablet manufacturing processes via wet granulation, aiding in process design, analysis, and optimization for improved product quality (Yeom et al, 2019).…”

Section: Process Modeling For Numerical Simulation In Manufacturingmentioning

confidence: 99%

Computational Pharmaceutics: A Comprehensive Review of Past Achievements, Present Applications, and Future Challenges

Chaudhari,

Puri

et al. 2024

Preprint

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This paper explores the transformative impact of computational pharmaceutics, integrating AI, multi-scale modeling, quantum computing, AI-driven drug discovery, and blockchain frameworks. Molecular dynamics simulations provide insights into atomic behaviors crucial for drug design. Quantum computing reduces computational costs for simulating protein-drug interactions. AI and Graph Neural Networks accelerate drug discovery and personalized medicine. Blockchain frameworks facilitate secure pharmacogenetic data sharing. These advancements revolutionize drug development, offering unprecedented efficiency, innovation, and personalized treatments.

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“…Mechanistic models, such as the discrete element method (DEM), have been utilized for powder-related processes like milling, blending, granulation, and coating, enhancing process understanding and control (Dong et al, 2023;Russell & Capece, 2022). Multivariable modeling techniques have been employed in tablet manufacturing to optimize processes, monitor quality attributes, and improve process control, especially in continuous manufacturing settings (Shi et al, 2021). Additionally, simulation modeling frameworks have been developed for pharmaceutical tablet manufacturing processes via wet granulation, aiding in process design, analysis, and optimization for improved product quality (Yeom et al, 2019).…”

Section: Process Modeling For Numerical Simulation In Manufacturingmentioning

confidence: 99%

Computational Pharmaceutics: A Comprehensive Review of Past Achievements, Present Applications, and Future Challenges

Chaudhari,

Puri

et al. 2024

Preprint

View full text Add to dashboard Cite

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Pharmaceutical application of multivariate modelling techniques: a review on the manufacturing of tablets

Abstract: Multivariate modeling techniques play important roles in the tablet manufacturing process.

Cited by 19 publications

References 292 publications

The Use of Novel, Rapid Analytical Tools in the Assessment of the Stability of Tablets—A Pilot Analysis of Expired and Unexpired Tablets Containing Nifuroxazide

The Use of Novel, Rapid Analytical Tools in the Assessment of the Stability of Tablets—A Pilot Analysis of Expired and Unexpired Tablets Containing Nifuroxazide

Computational Pharmaceutics: A Comprehensive Review of Past Achievements, Present Applications, and Future Challenges

Computational Pharmaceutics: A Comprehensive Review of Past Achievements, Present Applications, and Future Challenges

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