Pharmaceutical Application of Tablet Film Coating

Abstract

Tablet film coating is a common but critical process providing various functionalities to tablets, thereby meeting diverse clinical needs and increasing the value of oral solid dosage forms. Tablet film coating is a technology-driven process and the evolution of coated dosage forms relies on advancements in coating technology, equipment, analytical techniques, and coating materials. Although multiple coating techniques are developed for solvent-based or solvent-free coating processes, each method has advantages and disadvantages that may require continuous technical refinement. In the film coating process, intra- and inter-batch coating uniformity of tablets is critical to ensure the quality of the final product, especially for active film coating containing active pharmaceutical ingredients in the coating layer. In addition to experimental evaluation, computational modeling is also actively pursued to predict the influence of operation parameters on the quality of the final product and optimize process variables of tablet film coating. The concerted efforts of experiments and computational modeling can save time and cost in optimizing the tablet coating process. This review provides a brief overview of tablet film coating technology and modeling approaches with a focus on recent advancements in pharmaceutical applications.

Unexpected Salt/Cocrystal Polymorphism of the Ketoprofen–Lysine System: Discovery of a New Ketoprofen–l-Lysine Salt Polymorph with Different Physicochemical and Pharmacokinetic Properties

“…Answering this question is of particular interest, not only because of the regulatory and legal implications of intellectual property rights related to the discovery of a new polymorph [17], but most importantly because it could lead to the development of a drug that, while maintaining the same chemical composition of the polymorphic one, can have different pharmacokinetic and pharmacological characteristics. According to its physicochemical and pharmacokinetic properties, the polymorphic form may allow for the development of different formulations [18], which can be characterized, for example, by a slower or faster drug release in the blood; on the other hand, depending on its taste, a different coating process or flavor can be used to mask the drug taste, thus possibly affecting drug manufacturing costs and patient compliance [19]. Lastly, on the basis of all the pharmacokinetic and physicochemical characteristics of the new polymorph, new therapeutic indications can potentially be hypothesized.…”

In Vitro Assessment of Physicochemical Parameters of Five Generics Amlodipine Besylate Tablets Marketed in Yemen

“…Drug release rates can be controlled by the amount of polymers used for surface coating [26]. The disintegration times were determined for all five brands and the results are shown in table 4.…”

Aqueous Film Coating the Current Trend

“…Here coating of substrate is achieved by spraying solution of FFP in AS or VOS [11][12][13] . Furthermore the FC can improve stability by protecting substrate from humidity, temperature, and light; improve aesthetic property by masking obnoxious taste or odour, improving the appearance, facilitating swallowing; provide tablet identity; and modify or control release of the active [12][13][14] . The FC find applications for achieving release profile of the drug(s) that is either modified or conventional; accordingly the FC is either modified release FCs or conventional FCs [6][7][8] .…”