Pharmaceutical Particle Engineering via Nano Spray Drying - Process Parameters and Application Examples on the Laboratory-Scale

Arpagaus, Crpagaus

doi:10.23937/2378-3664.1410026

Cited by 39 publications

(37 citation statements)

References 65 publications

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“…1B). Numerous reviews and book chapters have already been published on the subject of nano spray drying technology Arpagaus 2011Arpagaus , 2012Arpagaus , 2018aArpagaus et al 2017Arpagaus et al , 2018Assadpour and Jafari 2019;Heng et al 2011;Lee et al 2011).…”

Section: Trend Towards Nano Spray Dryingmentioning

confidence: 99%

“…As shown schematically in Fig. 4A, the droplet temperature in a nano spray dryer rises initially to the saturated wetbulb surface temperature, remains constant during evaporation, and approaches the temperature of the surrounding gas at the dryer outlet (Arpagaus 2018a;Arpagaus et al 2017).…”

Section: Influence Of Process Parameters On Powder Propertiesmentioning

confidence: 99%

“…4 A Typical temperature profile of the drying gas and the droplets during nano spray drying. The influence of drying gas temperature, gas throughput and feed on the droplet temperature is illustrated schematically (Arpagaus 2018a;Arpagaus et al 2017). B Linear correlation between inlet (T in ) and outlet (T out ) drying gas temperature in the Nano Spray Dryer B-90 when spraying dichloromethane (DCM), i.e.…”

Section: Influence Of Process Parameters On Powder Propertiesmentioning

confidence: 99%

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PLA/PLGA nanoparticles prepared by nano spray drying

Arpagaus

2019

J. Pharm. Investig.

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Background Spray drying is a relatively simple, fast, reproducible and scalable drying technology that is suitable for drying heat-sensitive biopharmaceutical compounds. In view of the rapid progress of nanoencapsulation technologies in the pharmaceutical sector, nano spray drying is used in research to improve the powder formulation and release of active ingredients. The Nano Spray Dryer B-90 of the Swiss company Büchi Labortechnik AG extends the size of the powder particles produced into the nanometer scale with narrow size distributions and high encapsulation efficiency. Area covered This study explains the special nano spray drying technology and discusses the influence of the respective process parameters on the powder properties. Applications of nano spray drying for the formulation and encapsulation of active ingredients in PLA/PLGA biopolymers are investigated and discussed. Optimized process parameters for the application of nano spray drying of similar substances are presented. Expert opinion The analyzed studies show the possibility of producing PLGA particles from approx. 2 μm to below 200 nm by nano spray drying, as well as the encapsulation of various active ingredients in spherical particles and nano-in-nanoparticle composite structures made of PLGA polymers for controlled drug delivery systems. The researched applications are primarily in the therapeutic field, such as the treatment of inhalation diseases, inflammations, cancer, immune diseases, genetic disorders, the regulation of vasodilatation or the surface coating of medical implants with biocompatible PLGA nanoparticles.

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Section: Trend Towards Nano Spray Dryingmentioning

confidence: 99%

Section: Influence Of Process Parameters On Powder Propertiesmentioning

confidence: 99%

Section: Influence Of Process Parameters On Powder Propertiesmentioning

confidence: 99%

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PLA/PLGA nanoparticles prepared by nano spray drying

Arpagaus

2019

J. Pharm. Investig.

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“…Spray dryers disperse and atomize the nanosuspensions to droplets into a pre-heated gas stream that facilitates the evaporation of the liquid phase. The state of atomization increases the surface area available for mass and heat transfer, thus allowing for lower operating temperatures in comparison to convective drying methods [ 12 ]. However, SD may itself effect aggregation and drug degradation when eutectic melting occurs.…”

Section: Introductionmentioning

confidence: 99%

Overcoming the Solubility Barrier of Ibuprofen by the Rational Process Design of a Nanocrystal Formulation

et al. 2020

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Wet media milling, coupled with spay drying, is a commonly proposed formulation strategy for the production and solidification of nanosuspensions in order to overcome the solubility barrier of BCS Class II substances. However, the application of mechanically and thermally intensive processes is not straightforward in the cases of ductile and/or low melting point substances that may additionally be susceptible to eutectic formation. Using ibuprofen (IBU) as a model drug with non-favorable mechanical and melting properties, we attempt to rationalize nanocrystal formulation and manufacturing in an integrated approach by implementing Quality by Design (QbD) methodology, particle informatics techniques and computationally assisted process design. Wet media milling was performed in the presence of different stabilizers and co-milling agents, and the nanosuspensions were solidified by spray-drying. The effects of key process parameters (bead diameter, milling time and rotational speed) and formulation variables (stabilizer type and drug/stabilizer ratio) on the critical quality attributes (CQAs), i.e., Z-average size, polydispersity index (PDI), ζ-potential and redispersibility of spray-dried nanosuspensions were evaluated, while possible correlations between IBU free surface energy and stabilizer effectiveness were studied. The fracture mechanism and surface stabilization of IBU were investigated by computer simulation of the molecular interactions at the crystal lattice level. As a further step, process design accounting for mass-energy balances and predictive thermodynamic models were constructed to scale-up and optimize the design space. Contemplating several limitations, our multilevel approach offers insights on the mechanistic pathway applicable to the substances featuring thermosensitivity and eutectic tendency.

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“…Apparently, the above-mentioned parameters had no significant effect on the encapsulation efficiency [ 102 ]. In the pharmaceutical industry, spray drying technique plays a significant role in manufacturing of drug powders and other therapeutic products, and this technique, in particular, can produce a high drug encapsulation efficiency and operate under sterile conditions [ 103 , 104 ]. It has also become an attractive technique in other industries such as cosmetics [ 105 ], food [ 106 ], and photoluminescence [ 107 ].…”

Section: Alginate Nanoparticles Preparation Methodsmentioning

confidence: 99%

Alginate Nanoformulation: Influence of Process and Selected Variables

2020

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Nanocarriers are defined as structures and devices that are constructed using nanomaterials which add functionality to the encapsulants. Being small in size and having a customized surface, improved solubility and multi-functionality, it is envisaged that nanoparticles will continue to create new biomedical applications owing to their stability, solubility, and bioavailability, as well as controlled release of drugs. The type and physiochemical as well as morphological attributes of nanoparticles influence their interaction with living cells and determine the route of administration, clearance, as well as related toxic effects. Over the past decades, biodegradable polymers such as polysaccharides have drowned a great deal of attention in pharmaceutical industry with respect to designing of drug delivery systems. On this note, biodegradable polymeric nanocarrier is deemed to control the release of the drug, stabilize labile molecules from degradation and site-specific drug targeting, with the main aim of reducing the dosing frequency and prolonging the therapeutic outcomes. Thus, it is essential to select the appropriate biopolymer material, e.g., sodium alginate to formulate nanoparticles for controlled drug delivery. Alginate has attracted considerable interest in pharmaceutical and biomedical applications as a matrix material of nanocarriers due to its inherent biological properties, including good biocompatibility and biodegradability. Various techniques have been adopted to synthesize alginate nanoparticles in order to introduce more rational, coherent, efficient and cost-effective properties. This review highlights the most used and recent manufacturing techniques of alginate-based nanoparticulate delivery system, including emulsification/gelation complexation, layer-by-layer, spray drying, electrospray and electrospinning methods. Besides, the effects of the main processing and formulation parameters on alginate nanoparticles are also summarized.

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Pharmaceutical Particle Engineering via Nano Spray Drying - Process Parameters and Application Examples on the Laboratory-Scale

Cited by 39 publications

References 65 publications

PLA/PLGA nanoparticles prepared by nano spray drying

PLA/PLGA nanoparticles prepared by nano spray drying

Overcoming the Solubility Barrier of Ibuprofen by the Rational Process Design of a Nanocrystal Formulation

Alginate Nanoformulation: Influence of Process and Selected Variables

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