Pharmacodynamics and pharmacokinetics interaction between nefopam and tramadol in the broiler chicks model

Mousa, Yaareb J.; Mahmood, Mahmood B.

doi:10.33899/ijvs.2021.130163.1746

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Isobolographic Inspection Of the Analgesic Pharmacological I...1

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2023

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“…Later, dosages of the two drugs are decreased or elevated by 25% (i.e. 0.89 and 6.05 mg/kg, respectively) from the initial dosage injected before conferring to the occurrence or absence of analgesia (18)(19)(20). To estimate the mode of analgesic interaction concerning pethidine and tramadol administration in rats, pethidine, and tramadol resembling the analgesic ED50s were positioned onto x and y-axes (21)(22)(23).…”

Section: Isobolographic Inspection Of the Analgesic Pharmacological I...mentioning

confidence: 99%

Simultaneous determination of pethidine pharmacokinetics in rats: The impact of tramadol coadministration

Mousa¹,

Mahmood²,

Mohammed³

2023

IJVS

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The rats model has never thoroughly investigated the influence of tramadol on plasma pethidine concentration besides pethidine pharmacokinetics. Individually, analgesic ED50s for pethidine and tramadol are estimated as 3.55 and 24.21 mg/kg, i.p. Subsequently, their measures decreased to 1.65 and 11.27 mg/kg, i.p., when both were given in combination at 1:1 from ED50s. Tramadol and pethidine have a form of synergistic analgesic interaction, which is therefore classified as a pharmacodynamic interaction. Pethidine (7.1mg/kg, i.p.) reveals the plasma concentration of 369. 00, 493.33, 373.33, 305.33, 306.33 and 247.67 µg/ml that was measured over distinctive times of 0.25,0.5,1,2,4, and 24 hours. At the same time, the concentration of plasma levels of tramadol and pethidine (48.42 and 7.1mg/kg, i.p., correspondingly) declined to 229.

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Section: Isobolographic Inspection Of the Analgesic Pharmacological I...mentioning

confidence: 99%

Simultaneous determination of pethidine pharmacokinetics in rats: The impact of tramadol coadministration

Mousa¹,

Mahmood²,

Mohammed³

2023

IJVS

View full text Add to dashboard Cite

show abstract

Pharmacodynamics and pharmacokinetics interaction between nefopam and tramadol in the broiler chicks model

Cited by 1 publication

References 0 publications

Simultaneous determination of pethidine pharmacokinetics in rats: The impact of tramadol coadministration

Simultaneous determination of pethidine pharmacokinetics in rats: The impact of tramadol coadministration

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