Pharmacogenomics in general practice: The time has come

Polasek, Thomas M.; Mina, Kym; Suthers, Graeme

doi:10.31128/ajgp-10-18-4733

Cited by 23 publications

(20 citation statements)

References 23 publications

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“…Since the completion of this study, further efforts to prepare GPs for managing genomics in general practice include a focus edition of Australian Journal of General Practice on genomics in March 2019, comprising key topics on preconception/antenatal carrier screening, cardiovascular genomics, pharmacogenomics and insurance issues related to genetic testing. [33][34][35][36] Some HealthPathways, which are web-based information portals, are developing genetics pathways information for GPs. Postgraduate study in genomics for health professionals has commenced at both the University of Melbourne and the University of Sydney, and GP training was conducted in a number of states, including workshops in Queensland.…”

Section: Discussionmentioning

confidence: 99%

General practitioners’ views on genomics, practice and education: A qualitative interview study

Cusack¹,

Hickerton²,

Nisselle³

et al. 2021

Aust J Gen Pract

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2014-19. BT declares holding a part-time role in a commercial genomic testing subsidiary (Genome. One) of the Garvan Institute of Medical Research until July 2018. Outside of the submitted article, SM and KD received funding, through their work institutions, from The Royal Australian College of General Practitioners for the work they did as Co-Chair and Member, respectively, of the Advisory Group in the development of the clinical resource Genomics in general practice.

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Section: Discussionmentioning

confidence: 99%

General practitioners’ views on genomics, practice and education: A qualitative interview study

Cusack¹,

Hickerton²,

Nisselle³

et al. 2021

Aust J Gen Pract

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“…That is, prescribers are literally in a dosing ‘black hole’. 14 The foundation of modern medical training and practice is evidence-based medicine (EBM), defined as ‘the conscientious explicit and judicious use of current best evidence in making decision about the care of individual patients’. 15 However, the caveat of EBM for drug therapy is that the evidence, at least in the initial stages of a drug’s life, is from industry-sponsored RCTs not designed usually to account for large between patient variability in drug exposure.…”

Section: Reasons Why Precision Dosing Is Important To Avoid Adrsmentioning

confidence: 99%

Precision dosing to avoid adverse drug reactions

Polasek

Kirkpatrick

Rostami‐Hodjegan

2019

Therapeutic Advances in Drug Safety

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Adverse drug reactions (ADRs) have traditionally been managed by trial and error, adjusting drug and dose selection reactively following patient harm. With an improved understanding of ADRs, and the patient characteristics that increase susceptibility, precision medicine technologies enable a proactive approach to ADRs and support clinicians to change prescribing accordingly. This commentary revisits the famous pharmacology–toxicology continuum first postulated by Paracelsus 500 years ago and explains why precision dosing is needed to help avoid ADRs in modern clinical practice. Strategies on how to improve precision dosing are given, including more research to establish better precision dosing targets in the cases of greatest need, easier access to dosing instructions via e-prescribing, improved monitoring of patients with novel biomarkers of drug response, and further application of model-informed precision dosing.

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“…PGx aid in individualizing therapies according to the genotypes of patients, through which the genetic variations attributed to medication disposition can be tested upfront to predict variability of patients’ responses to the administered drugs ( Kisor et al, 2019 ). The incorporation of pharmacogenetic testing might contribute to better patient outcomes by reducing side effects and improving the overall effectiveness of the prescribed medications ( Polasek et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%