Pharmacognostic study and anti – inflammatory activity of Phyllanthus reticulatus Poir. fruit

Kumar, Sunil; Sharma, Shalini; Kumar, Dinesh; Kumar, Tarun; Arya, Renu; Kumar, Karunesh

doi:10.1016/s2222-1808(12)60177-7

Cited by 11 publications

(4 citation statements)

References 7 publications

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“…Methanolic extract of P. reticulatus was given at a dose of 400 mg/kg b.w., p.o. [ 12 ]. Then, after 1 h of extract administration, ethanol (100%) was given in a single oral dose (5 ml/kg b.w.).…”

Section: Methodsmentioning

confidence: 99%

“…Rats were pretreated with n -hexane fraction of P. reticulatus at a dose of 400 mg/kg b.w., p.o. [ 12 ]. Then, after 1 h of pretreatment, absolute ethanol was administered in a single oral dose (5 ml/kg b.w.).…”

Section: Methodsmentioning

confidence: 99%

“…This group was pretreated with ethyl acetate fraction of P. reticulatus at a dose of 400 mg/kg b.w., p.o. [ 12 ]. Absolute ethanol was administered (5 ml/kg b.w.)…”

Section: Methodsmentioning

confidence: 99%

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Phyllanthus reticulatus Prevents Ethanol-Induced Gastric Ulcer via Downregulation of IL-8 and TNF-α Levels

Izhar

Shabbir

Shahzad

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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The current study aimed to determine the protective effect of P. reticulatus on ethanol-induced gastric ulcer. For this purpose, thirty-six Sprague-Dawley rats were divided into six groups. The first group served as normal control, while, in other five groups, absolute ethanol was used to induce gastric ulcer. Group II served as a diseased group, while groups III, IV, and V were treated with methanol extract, ethyl acetate fraction, and n-hexane fraction, respectively, in a dose of 400 mg/kg bodyweight. Group VI was given omeprazole in a dose 20 mg/kg bodyweight. The stomachs were removed, ulcer score was evaluated, and histopathological examination of gastric lumen was conducted. Total acidity and pH values were determined in gastric juice. TNF-α and IL-8 mRNA expressions levels were determined using the reverse transcription real-time PCR method. The data indicated that P. reticulatus protected against gastric ulcer, which was evident by attenuation of ulcer score. The pretreatment with P. reticulatus raised the gastric pH and improved all evaluated histopathological parameters such as ulcer score, erosion score, hemorrhage score, fibrinoid necrosis score, inflammatory infiltrate score, and edema score. P. reticulatus significantly reduced mRNA expression levels of TNF-α and IL-8. In conclusion, P. reticulatus possess antiulcer property which might be attributed to downregulation of TNF-α and IL-8 expression levels.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Phyllanthus reticulatus Prevents Ethanol-Induced Gastric Ulcer via Downregulation of IL-8 and TNF-α Levels

Izhar

Shabbir

Shahzad

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…P. reticulatus is a shrub and grows throughout tropical areas of Bangladesh, India, China and the Malay Islands. This plant has been reported to attenuate carrageenan induced paw edema in both mice and rats treated with bark and leaf extracts [117][118][119][120]. In in vitro investigations this plant inhibited lysis of RBC membrane [121].…”

Section: Anthocephalus Cadamba (Roxb) Miqmentioning

confidence: 99%

Management of inflammatory disorders: A brief review of selected ethnomedicinal plants

Akhtar,

Khan,

Zahan

2023

JPP

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Medicinal plants have immense significance to treat various diseases and have great potential to discover and develop new therapies. This paper aims to summarize the in vitro and in vivo investigations conducted to evaluate the anti-inflammatory activities of selected medicinal plants of Bangladesh. The anti-inflammatory active molecules reported from those selected plants have also been highlighted. The species included in this review are Abelmoschus esculentus (L.) Moench, Asparagus racemosus Willd., Blumea lacera (Burm.f.) DC., Butea monosperma (Lam.) Taub., Cheilocostus speciosus (J.Koenig) C.D.Specht., Mussaenda roxburghii Hook. f., Anthocephalus cadamba (Roxb.) Miq., Phyllanthus reticulatus Poir., Sesbania grandiflora (L.) Pers. and Spondias pinnata (L. f.) Kurz. The toxic effect of these plants has also been included briefly. We hope that this overview will shed some light on the function of these plants and their molecules in the treatment of various inflammatory diseases and will attract the attention of investigators interested in designing novel therapeutic approaches.

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Physicochemical and antimicrobial properties of Phyllanthus reticulatus fruit extract doped chitosan/poly (vinyl alcohol) blend films for food packaging applications

Hiremani¹,

Goudar

Khanapure

et al. 2022

Food Measure

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Pharmacognostic study and anti – inflammatory activity of Phyllanthus reticulatus Poir. fruit

Cited by 11 publications

References 7 publications

Phyllanthus reticulatus Prevents Ethanol-Induced Gastric Ulcer via Downregulation of IL-8 and TNF-α Levels

Phyllanthus reticulatus Prevents Ethanol-Induced Gastric Ulcer via Downregulation of IL-8 and TNF-α Levels

Management of inflammatory disorders: A brief review of selected ethnomedicinal plants

Physicochemical and antimicrobial properties of Phyllanthus reticulatus fruit extract doped chitosan/poly (vinyl alcohol) blend films for food packaging applications

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