Pharmacokinetics and tissue distribution study of liposomal albendazole in naturally Echinococcus granulosus infected sheep by a validated UPLC-Q-TOF-MS method

Zhang, Haibo; Zhao, Jun; Chen, Bei; Ma, Ya‐Hui; Li, Zhiqiang; Shou, Xi; Wen, Limei; Yuan, Yuan; Gao, Huijing; Ruan, Jie; Li, Hongling; Yin, Zhimin; Gong, Yuehong; Wang, Jianhua; Wen, Hao

doi:10.1016/j.jchromb.2020.122016

Cited by 8 publications

(8 citation statements)

References 23 publications

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“…ABZ was not detected in any plasma sample. Its extensive metabolization to ABZSO and ABZSO 2 , and the plasma profiles obtained in this study for both metabolites after oral administration to sheep are consistent with those previously published in other studies [ 11 , 14 , 21 , 41 , 42 , 43 , 44 , 45 ].…”

Section: Discussionsupporting

confidence: 91%

“…The rate of dissolution in the gastrointestinal tract of benzimidazoles is thought to be critical in achieving adequate absorption and, consequently, clinical efficacy. Different approaches have been assessed to increase its oral bioavailability, including alternative drug formulations to improve aqueous solubility [ 2 , 21 ], interferences in liver biotransformation [ 15 , 22 ], and non-chemical strategies, such as management of feed intake [ 23 , 24 ] or prior fasting to administration [ 25 , 26 ]. Although these approaches have improved the knowledge on the pharmacokinetic behavior of ABZ, none of them has been finally translated into the SPC of the medicinal products containing ABZ and thus, to daily clinical practice.…”

Section: Introductionmentioning

confidence: 99%

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Improvement of Albendazole Bioavailability with Menbutone Administration in Sheep

Díez

Diez

García

et al. 2022

Animals

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The pharmacokinetic interaction between a benzimidazole (albendazole, ABZ) and a choleretic drug (menbutone, MEN) was evaluated in sheep. The plasma disposition of albendazole sulfoxide (ABZSO, active metabolite) and albendazole sulfone (ABZSO2, inactive metabolite) was investigated following an oral administration of albendazole (ABZ) (5 mg/kg) alone or with menbutone (MEN) (intramuscular, 10 mg/kg). Blood samples were collected over 3 days post-treatment, and drug plasma concentrations were measured by high performance liquid chromatography (HPLC). ABZSO was measured from 0.5 to 48 h, and ABZSO2 from 2 to 60 h. No parent drug was detected at any sampling time. Mean maximum plasma concentration (Cmax) and the area under the plasma concentration-time curve (AUC) were 12.8% and 21.5% higher for ABZSO when ABZ and MEN were administered together, which indicates a significant increase in the amount absorbed. The rate of absorption was not modified, with similar values for the time to reach Cmax (tmax) (11.5 h with ABZ + MEN and 10.7 h with ABZ treatment), although no significant differences were observed for these latter pharmacokinetic parameters. Regarding ABZSO2, Cmax, AUC and tmax values were similar after both treatments (ABZ or ABZ + MEN). The results obtained indicate that co-administration of ABZ and MEN may be an interesting and practical option to increase the efficacy of this anthelmintic.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Improvement of Albendazole Bioavailability with Menbutone Administration in Sheep

Díez

Diez

García

et al. 2022

Animals

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“…The composition of the mobile phase has a substantial influence on the separation and peak shape of analytes. In relevant studies on the simultaneous detection of ABZ and its three metabolites in animal-derived foods, at present, the water (containing a small amount of organic acid)-acetonitrile [17][18][19] mobile phase system and the water (containing a small amount of formic acid)-methanol [21][22][23] mobile phase system are frequently used. In this study, when 69% water (containing 0.2% formic acid and 31% methanol was used as the mobile phase, the chromatogram showed large fluctuations at 4-6 min in the gradient elution procedure, which caused the ABZ peak to be lost.…”

Section: Optimization Of the Mobile Phasementioning

confidence: 99%

Simultaneous Determination of Albendazole and Its Three Metabolites in Pig and Poultry Muscle by Ultrahigh-Performance Liquid Chromatography-Fluorescence Detection

Diao

Guo

Xie

et al. 2021

Foods

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A fast, simple and efficient ultrahigh-performance liquid chromatography-fluorescence detection (UPLC-FLD) method for the determination of residues of albendazole (ABZ) and its three metabolites, albendazole sulfone (ABZ-SO2), albendazole sulfoxide (ABZ-SO), and albendazole-2-aminosulfone (ABZ-2NH2-SO2), in pig and poultry muscle (chicken, duck and goose) was established. The samples were extracted with ethyl acetate, and the extracts were further subjected to cleanup by utilizing a series of liquid–liquid extraction (LLE) steps. Then, extracts were purified by OASIS® PRiME hydrophilic-lipophilic balance (HLB) solid-phase extraction (SPE) cartridges (60 mg/3 mL). The target compounds were separated on an ACQUITY UPLC® BEH C18 (2.1 mm × 100 mm, 1.7 μm) chromatographic column, using a mobile phase composed of 31% acetonitrile and 69% aqueous solution (containing 0.2% formic acid and 0.05% triethylamine). The limits of detection (LODs) and limits of quantification (LOQs) of the four target compounds in pig and poultry muscle were 0.2–3.8 µg/kg and 1.0–10.9 µg/kg, respectively. The recoveries were all above 80.37% when the muscle samples were spiked with the four target compounds at the LOQ, 0.5 maximum residue limit (MRL), 1.0 MRL, and 2.0 MRL levels. The intraday relative standard deviations (RSDs) were less than 5.11%, and the interday RSDs were less than 6.29%.

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“…In total, 18 bioactive components in rat plasma after oral administration of QSKL formula were quantified, and the pharmacokinetics of the bioactive components in healthy animals was investigated 14 . However, studies have demonstrated that disease conditions cause the alteration of pharmacokinetic behavior and tissue distribution 15,16 . For better use of QSKL in clinical therapy, it is necessary to study the pharmacokinetic properties and tissue distribution profiles of the bioactive components in QSKL in pathological states.…”

Section: Introductionmentioning

confidence: 99%

“…14 However, studies have demonstrated that disease conditions cause the alteration of pharmacokinetic behavior and tissue distribution. 15,16 For better use of QSKL in clinical therapy, it is necessary to study the pharmacokinetic properties and tissue distribution profiles of the bioactive components in QSKL in pathological states.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics and tissue distribution study of 18 bioactive components in healthy and chronic heart failure rats after oral administration of Qi‐Shen‐Ke‐Li formula using ultra‐high‐performance liquid chromatography/triple quadrupole mass spectrometry

Zhou

Zheng

et al. 2021

Rapid Comm Mass Spectrometry

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Rationale Qi‐Shen‐Ke‐Li (QSKL) is a traditional Chinese formula used in clinical practice to treat chronic heart failure (CHF) in humans. To rationalize the use of this formula in clinical practice, the pharmacokinetics and tissue distribution in rats after oral administration of QSKL were investigated using ultra‐high‐performance liquid chromatography/triple quadrupole mass spectrometry (UHPLC/TQ‐MS). Methods The CHF model was induced by intraperitoneal injection of isoprenaline (ISO; also known as isoproterenol) and evaluated by HE staining and brain natriuretic peptide (BNP) measurement. The UHPLC/TQ‐MS method was then applied to determine the concentrations of 18 bioactive components in rat plasma and tissues of heathy and CHF rats after oral administration of QSKL. This was followed by investigating the pharmacokinetics and tissue distribution profiles of these bioactive compounds in the heathy and CHF rats. Results The pharmacokinetics results showed that the duration time of two compounds was prolonged, the absorption rate of four compounds was accelerated, and the bioavailability of four compounds was increased in the CHF rats compared with the healthy rats. Meanwhile, the tissue distribution results showed that the QSKL formula could be distributed rapidly and widely in different rat tissues. The bioavailability of eight compounds in the liver was enhanced in CHF rats. This suggested that the drug/toxic effects should be considered in clinical practice, as drug–drug interactions might occur in liver metabolism during the drug combination. Conclusions The pharmacokinetic profiles and tissue distribution of 18 bioactive compounds in QSKL are altered by the CHF status. This study provides insight for better clinical applications of this formula in the future and lays the foundation for the development of a new drug for chronic heart failure based on the QSKL formula.

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Pharmacokinetics and tissue distribution study of liposomal albendazole in naturally Echinococcus granulosus infected sheep by a validated UPLC-Q-TOF-MS method

Cited by 8 publications

References 23 publications

Improvement of Albendazole Bioavailability with Menbutone Administration in Sheep

Improvement of Albendazole Bioavailability with Menbutone Administration in Sheep

Simultaneous Determination of Albendazole and Its Three Metabolites in Pig and Poultry Muscle by Ultrahigh-Performance Liquid Chromatography-Fluorescence Detection

Pharmacokinetics and tissue distribution study of 18 bioactive components in healthy and chronic heart failure rats after oral administration of Qi‐Shen‐Ke‐Li formula using ultra‐high‐performance liquid chromatography/triple quadrupole mass spectrometry

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