Pharmacological activities of pyridazines and pyridazinone Derivatives: A Review on biologically active scaffold

Abstract

Pyridazine and pyridazinone derivatives compounds are biologically important compounds. Pyridazinone has carbonyl group on third carbon on pyridazine ring. Pyridazine and pyridazinone is a wonder nucleus because their derivatives give amost all types of biological activities such as such as analgesic, antiinflammatory, antimicrobial, antisecretory, antiulcer, antidepressants, neuroleptics, anxiolytics, sedative, hypnotic, tranquillizer, anticonvulsant, antiplatelet, antithrombotics, anticancer, antihistamine, cardiotonics, vasodilatators, antiarrhythmics, antidiabetic, antihypertensive, antitubercular and various other types of activities. These compounds are synthesized with the aim of novel agents those possess interesting biological activities. The present review has been focused on the pyridazine and pyridazinone derivatives with potential pharmacologica activities.

Pyridazine derivatives as selective COX‐2 inhibitors: A review on recent updates

“…Pyridazine and pyridazinone derivatives, which have two nitrogen atoms in an adjacent position in a six‐member ring, belong to a significant class of heterocyclic compounds. Since pyridazine and pyridazinone rings are simple to be functionalized, their derivatives are useful compounds for the design and development of novel pharmacotherapeutic agents (Alam et al, 2019).…”