2024
DOI: 10.2174/0115701611266576231211045731
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Pharmacological Agents and Potential New Therapies in Pulmonary Arterial Hypertension

Renata Trabach Santos,
Maria Eduarda de Sá Freire Onofre,
Dayene de Assis Fernandes Caldeira
et al.

Abstract: Pulmonary arterial hypertension (PAH) is a progressive disease characterized by an imbalance between vasoactive mediators, which causes vascular remodeling, increased pulmonary vascular resistance, and right ventricular overload, ultimately leading to heart failure and death. A metabolic theory has been suggested to explain the pathophysiology of PAH whereby abnormalities in mitochondrial biogenesis can trigger a hyperproliferative and apoptosis-resistant phenotype in cardiopulmonary and malignant cells, leadi… Show more

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