Pharmacological Cholinergic Stimulation as a Therapeutic Tool in Experimental Necrotizing Pancreatitis

Schneider, Lutz; Jabrailova, Bahar; Soliman, Hussein H.; Hofer, Stefan; Strobel, Oliver; Hackert, Thilo; Büchler, Markus W.; Werner, Jens

doi:10.1097/mpa.0b013e3182a85c21

Cited by 28 publications

(22 citation statements)

References 44 publications

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“…However, there are studies which also suggest a protective 'anti inflammatory' role for nicotine in experimental AP. The postulated mechanisms by which nicotine exerts these effects include pathways mediated by the vagus and involving nicotinic receptors [93], cholinergic stimulation [94], modulating the immunoregulation of CD4 CD25 regulatory T cells [95]. It is likely that the cholinergic stimulation (via a(7)-nAChR) may result in the inhibition of the release of tumour necrosis factor (TNF) by macrophages [96].…”

Section: The Inflammatory Systemmentioning

confidence: 99%

How does cigarette smoking cause acute pancreatitis?

Barreto

2016

Pancreatology

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Section: The Inflammatory Systemmentioning

confidence: 99%

How does cigarette smoking cause acute pancreatitis?

Barreto

2016

Pancreatology

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“…They and others showed that electrical and pharmacological activation of the vagus inhibits many mostly innate immune responses ranging from cytokine responses to bacterial toxins as endotoxin, inflammation related to ileus, rheumatoid arthritis, colitis, hemorrhagic shock, myocardial ischemia/reperfusion, experimental pancreatitis and others [86][87][88][89][90]. The interaction of acetylcholine with nicotinic alpha7-ACh receptors (AChRs) on inflammatory cells plays an important role in the cholinergic anti-inflammatory pathway [85].…”

Section: Interplay Of Immune System and Nervous Systemmentioning

confidence: 98%

The innate immune response

2014

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“…[79] In another investigation, both prophylactic and delayed-therapeutic treatment with nicotine diminished severity of acute experimental pancreatitis via stimulation of the cholinergic anti-inflammatory pathway. [80]…”

Section: Underlying Cellular Mechanisms Of Smoking-related Pancreatitismentioning

confidence: 99%

Epidemiologic and Mechanistic Associations Between Smoking and Pancreatitis

Greer

Thrower

Yadav

2015

Curr Treat Options Gastro

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Opinion Statement Alcohol has long been associated with pancreatitis. Although first described more than 3 decades ago, smoking has been widely accepted as an important risk factor for all forms of pancreatitis only in the past few years. Empiric data has confirmed smoking as an independent and dose-dependent risk for both acute and chronic pancreatitis. Smoking also increases the risk of recurrences and progression of established chronic pancreatitis. The effects of smoking are enhanced in the presence of alcohol consumption. Indirect evidence suggests that smoking cessation may be beneficial in preventing disease progression. Smoking cessation can therefore be an important strategy for primary as well as secondary prevention of pancreatitis. Therefore, in addition to alcohol, physicians should routinely counsel patients for the benefits of smoking cessation. The mechanisms through which cigarette smoke triggers pathological cellular events, resulting in pancreatitis, are unresolved. Although cigarette smoke contains greater than 4000 compounds, principally nicotine and the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), have been broadly studied with regard to pancreatic diseases. Both nicotine and NNK have been shown to induce morphological changes in the pancreas consistent with those seen in pancreatitis. Furthermore, nicotine affects pancreatic secretion and NNK induces premature zymogen activation, two well-known features of pancreatitis. These cigarette toxins may mediate both pro- and anti-inflammatory pathways and can induce changes in pancreatic acinar cell function at the level of transcription, leading to conditions such as thiamin deficiency and mitochondrial dysfunction. Such circumstances could leave the pancreas prone to the development of pancreatitis. This review summarizes relevant research findings and focuses on the epidemiologic links between smoking and pancreatitis, and the cellular pathways that may be significant in induction and evolution of smoking-related pancreatitis.

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Pharmacological Cholinergic Stimulation as a Therapeutic Tool in Experimental Necrotizing Pancreatitis

Abstract: Stimulation of the cholinergic system is useful to attenuate damage in experimental acute pancreatitis. Not only prophylactic but also delayed application was effective in the present study.

Cited by 28 publications

References 44 publications

How does cigarette smoking cause acute pancreatitis?

How does cigarette smoking cause acute pancreatitis?

The innate immune response

Epidemiologic and Mechanistic Associations Between Smoking and Pancreatitis

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