Pharmacological targets at the lysosomal autophagy–NLRP3 inflammasome crossroads

Bonam, Srinivasa Reddy; Mastrippolito, Dylan; Georgel, Philippe; Muller, Sylviane

doi:10.1016/j.tips.2023.11.005

Trends in Pharmacological Sciences

2024

DOI: 10.1016/j.tips.2023.11.005

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Pharmacological targets at the lysosomal autophagy–NLRP3 inflammasome crossroads

Srinivasa Reddy Bonam,

Dylan Mastrippolito,

Philippe Georgel

et al.

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Cited by 11 publications

References 130 publications

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Interaction Between Autophagy and the Inflammasome in Human Tumors: Implications for the Treatment of Human Cancers

Xia,

Zhang

2024

Cell Biochemistry & Function

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Autophagy is a physiologically regulated cellular process orchestrated by autophagy‐related genes (ATGs) that, depending on the tumor type and stage, can either promote or suppress tumor growth and progression. It can also modulate cancer stem cell maintenance and immune responses. Therefore, targeted manipulation of autophagy may inhibit tumor development by overcoming tumor‐promoting mechanisms. The inflammasome is another multifunctional bioprocess that induces a form of pro‐inflammatory programmed cell death, called pyroptosis. Dysregulation or overactivation of the inflammasome has been implicated in tumor pathogenesis and development. Additionally, autophagy can inhibit the NLRP3 inflammasome by removing inflammatory drivers. Recent research suggests that the NLRP3 inflammasome, in turn, affects autophagy. Understanding the complex interplay between autophagy and inflammasomes could lead to more precise and effective strategies for cancer treatments. In this review, we summarize the impact of autophagy and inflammasome dysregulation on tumor progression or suppression. We then highlight their targeting for cancer treatment as monotherapy or in combination with other therapies. Furthermore, we discuss the interaction between autophagy and tumor‐promoting inflammation or the NLRP3 inflammasome. Finally, based on recent findings, we review the potential of this interaction for cancer treatment.

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Interaction Between Autophagy and the Inflammasome in Human Tumors: Implications for the Treatment of Human Cancers

Xia,

Zhang

2024

Cell Biochemistry & Function

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Functional transformation of macrophage mitochondria in cardiovascular diseases

Wei,

Peng,

2024

Mol Cell Biochem

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Inclusion body myositis: Correcting impaired mitochondrial and lysosomal autophagy as a potential therapeutic strategy

Brady,

Poulton,

Muller

2024

Autoimmunity Reviews

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Pharmacological targets at the lysosomal autophagy–NLRP3 inflammasome crossroads

Cited by 11 publications

References 130 publications

Interaction Between Autophagy and the Inflammasome in Human Tumors: Implications for the Treatment of Human Cancers

Interaction Between Autophagy and the Inflammasome in Human Tumors: Implications for the Treatment of Human Cancers

Functional transformation of macrophage mitochondria in cardiovascular diseases

Inclusion body myositis: Correcting impaired mitochondrial and lysosomal autophagy as a potential therapeutic strategy

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